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Ace2em1(ACE2)Dfl
Endonuclease-mediated Allele Detail
Summary
Symbol: Ace2em1(ACE2)Dfl
Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Dongfang Liu
MGI ID: MGI:8250890
Synonyms: hACE2KI, hACE2KI-NSG
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance: Ace2em1(ACE2)Dfl page
Mutation
origin
Strain of Origin:  NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Ace2em1(ACE2)Dfl expresses 1 gene
 
Mutation detailsThe human ACE2 cDNA (Genbank seqID NM_011371415.1) was inserted in frame with mouse Ace2 in exon 1 using CRISPR/Cas9 technology. The mouse Ace2 5' UTR and the first 15 amino acids encoding the leader sequence are retained and the remainder of the mouse sequence is replaced with the human ACE2 cDNA. (J:369237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  70 strains or lines available
References
Original:  J:369237 Badeti S, et al., Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection. Cell Biosci. 2022 Jun 11;12(1):88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/30/2025
MGI 6.24
The Jackson Laboratory