Ten1 MGI Mouse Gene Detail - MGI:1916785 - TEN1 telomerase capping complex subunit

Symbol

Ten1
Name

TEN1 telomerase capping complex subunit
Synonyms

2310004N24Rik

Feature Type

protein coding gene
IDs

MGI:1916785
NCBI Gene: 69535
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:116089681-116106144 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.00 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

553 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916785	protein coding gene	Chr11:116089681-116106144 (+)
129S1/SvImJ	ENSMUSG00200050983	protein coding gene	Chr11:113456009-113472470 (+)
A/J	ENSMUSG00195027959	protein coding gene	Chr11:113160697-113177222 (+)
AKR/J	ENSMUSG00220029372	protein coding gene	Chr11:113265028-113281374 (+)
BALB/cJ	ENSMUSG00180047800	protein coding gene	Chr11:113457445-113473907 (+)
C3H/HeJ	ENSMUSG00175033332	protein coding gene	Chr11:113412473-113428995 (+)
C57BL/6NJ	ENSMUSG00215043510	protein coding gene	Chr11:112949838-112966302 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017435	protein coding gene	Chr11:112050011-112066277 (+)
CAST/EiJ	ENSTCUG00005032860	protein coding gene	Chr11:112814798-112831941 (+)
CBA/J	ENSMUSG00210050078	protein coding gene	Chr11:113132470-113148987 (+)
DBA/2J	ENSMUSG00185025376	protein coding gene	Chr11:113448943-113465406 (+)
FVB/NJ	ENSMUSG00205038660	protein coding gene	Chr11:113254703-113271155 (+)
JF1/MsJ	ENSUMUG00000052272	protein coding gene	Chr11:113716874-113733476 (+)
LP/J	ENSMUSG00230049952	protein coding gene	Chr11:114505799-114522324 (+)
NOD/ShiLtJ	ENSMUSG00190046365	protein coding gene	Chr11:113480416-113496875 (+)
NZO/HlLtJ	ENSMUSG00225050064	protein coding gene	Chr11:116558561-116575020 (+)
PWK/PhJ	ENSLUMG00010021274	protein coding gene	Chr11:113233588-113249987 (+)
SPRET/EiJ	ENSMSPG00010039239	protein coding gene	Chr11:113753986-113769814 (+)
WSB/EiJ	ENSIUOG00005038379	protein coding gene	Chr11:113220949-113237406 (+)

Human Ortholog

TEN1, TEN1 subunit of CST complex

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEN1, TEN1 subunit of CST complex
Synonyms

C17orf106
Links

HGNC:37242

NCBI Gene ID: 100134934

UniProt: Q86WV5
Chr Location

chr17:75979235-76000587 (+) GRCh38

MGI Vertebrate Homology

Ten1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TEN1
Gene Tree

Ten1

Diseases

1 with Ten1 mouse models

Human Disease

Mouse Models

dyskeratosis congenita

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

53 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

11
Targeted

2
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show failure to thrive, short life span, telomere shortening, skin hyperpigmentation, alopecia, tongue hyperkeratosis, aplastic anemia, cerebellar hypoplasia, bone marrow failure, thymic atrophy, neurologic defects, retinal degeneration, and decreased cell proliferation along with apoptosis induction and increased inflammation in several organs.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

35

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ten1

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS48982.1

Ensembl

ENSMUSG00000020778 (Evidence)
NCBI Gene

69535

			Length	Strain/Species	Flank
genomic	69535	NCBI Gene Model \| MGI Sequence Detail	16464	C57BL/6J	± kb
transcript	NM_027107	RefSeq \| MGI Sequence Detail	919	C57BL/6
polypeptide	Q9D7K2	UniProt \| EBI \| MGI Sequence Detail	161	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032571 CST complex subunit TEN1

(term hierarchy)
InterPro Domains

IPR029146 CST complex subunit Ten1, animal and plant type

IPR012340 Nucleic acid-binding, OB-fold

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All nucleic 35

cDNA 35

Microarray probesets 3

Summaries

All 40

Diseases 1

Gene Ontology 6

Phenotypes 12
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:365069 Sanz-Moreno A, et al., Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita. Sci Adv. 2025 Apr 11;11(15):eadp8093

TSS for Ten1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105949	Chr11:116089679-116089729 (+)	23 bp
Tssr105950	Chr11:116101789-116101832 (+)	12,130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29