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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ten1
TEN1 telomerase capping complex subunit
MGI:1916785
52 phenotypes from 1 allele in 1 genetic background
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ten1em1(IMPC)Hmgu/Ten1+
involves: C57BL/6NCrl 		no abnormal phenotype detected J:365069
Ten1em1(IMPC)Hmgu/Ten1em1(IMPC)Hmgu
involves: C57BL/6NCrl 		abnormal bone marrow hematopoietic cell morphology J:365069
abnormal cell physiology J:365069
abnormal cerebellar Purkinje cell layer J:365069
abnormal cerebellum morphology J:365069
abnormal cytokine secretion J:365069
abnormal double-strand DNA break repair J:365069
abnormal intestinal mucosa morphology J:365069
abnormal retina morphology J:365069
abnormal skin morphology J:365069
abnormal telomere morphology J:365069
abnormal thymus medulla morphology J:365069
abnormal tongue morphology J:365069
alopecia J:365069
anemia J:365069
anterior iris synechia J:365069
ataxia J:365069
bone marrow failure J:365069
cerebellum hypoplasia J:365069
decreased birth body size J:365069
decreased birth weight J:365069
decreased body weight J:365069
decreased cell proliferation J:365069
decreased cerebellar granule cell number J:365069
decreased chondrocyte number J:365069
decreased cornea thickness J:365069
decreased intestinal crypt stem cell number J:365069
decreased locomotor activity J:365069
decreased telomere length J:365069
decreased total retina thickness J:365069
decreased width of hypertrophic chondrocyte zone J:365069
early cellular replicative senescence J:365069
hyperkeratosis J:365069
increased apoptosis J:365069
increased hindbrain apoptosis J:365069
increased inflammatory response J:365069
increased skin pigmentation J:365069
increased small intestinal crypt cell apoptosis J:365069
postnatal growth retardation J:365069
postnatal lethality, incomplete penetrance J:365069
premature death J:365069
retina degeneration J:365069
seizures J:365069
normal skeleton phenotype J:365069
small intestinal villus atrophy J:365069
thin dermal layer J:365069
thin hypodermis J:365069
thin retina inner nuclear layer J:365069
thin retina outer nuclear layer J:365069
thymus atrophy J:365069
thymus cortex hypoplasia J:365069
tremors J:365069
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory