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Pink1
Gene Detail
Symbol

Name
ID
Pink1
PTEN induced putative kinase 1
MGI:1916193
Synonyms
1190006F07Rik, brpk
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:138313409-138326307 bp, - strand
From VEGA annotation of GRCm38

  12899 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PINK1
Gene Tree: Pink1

Human
homologs
PINK1, PTEN induced putative kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 65018
neXtProt AC: NX_Q9BXM7

Human Synonyms: BRPK, PARK6

Human Chr (Location): 1p36; chr1:20633455-20651511 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PINK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Genomic Mutations involving Pink1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Some mice homozygous for null mutations exhibit decreased dopamine content, reduced long term potentional and depression, mitochondrial abnormalities, and/or behavioral abnormalities. Some null mice model the early stages of Parkinson Disease.
 
Human Diseases Modeled in Mice Using Pink1 (1)    Mutations Annotated to Human Diseases (4)   
Interactions
Pink1 interacts with 64 markers (Mir18, Mir22, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (153)    Tissues (113)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 149
Northern blot 3
RT-PCR 1
cDNA source data(197)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN pink1    NEW 
Molecular
reagents
All nucleic(199) cDNA(197) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009975 (Evidence)
Ensembl Gene Model ENSMUSG00000028756 (Evidence)
Entrez Gene 68943 (Evidence)
UniGene 18539
DFCI TC1572142, TC1731340, TC1767303
DoTS DT.103564506, DT.110792392, DT.534899
NIA Mouse Gene Index U025686
EC 2.7.11.1
Consensus CDS Project CCDS18825.1
International Mouse Phenotyping Consortium Status Pink1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009975 VEGA Gene Model | MGI Sequence Detail 12899 C57BL/6J ±  kb
transcript OTTMUST00000023184 VEGA | MGI Sequence Detail 2375 Not Applicable 
polypeptide OTTMUSP00000010580 VEGA | MGI Sequence Detail 580 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(265 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012737 serine/threonine-protein kinase PINK1, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:222295 Triplett JC, et al., Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease. J Neurochem. 2015 Jun;133(5):750-65
All references(87)
Disease annotation references (6)
Other
accession IDs
MGI:2140484, MGI:2140604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory