Pink1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pink1
PTEN induced putative kinase 1
MGI:1916193

37 phenotypes from 8 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pink1^tm1.1Wrst/Pink1^tm1.1Wrst involves: 129S2/SvPas * BALB/cJ * C57BL/6J	abnormal gait	J:183290
	abnormal innervation	J:183290
	abnormal mitochondrial morphology	J:183290
	abnormal olfaction	J:183290
	abnormal olfactory bulb glomerular layer morphology	J:183290
	abnormal sensory capabilities/reflexes/nociception	J:183290
	abnormal social investigation	J:183290
	normal behavior/neurological phenotype	J:183290
	normal nervous system phenotype	J:183290
Pink1^tm1Aub/Pink1^tm1Aub involves: 129S/SvEv	abnormal cellular respiration	J:150206
	abnormal mitochondrial ATP synthesis coupled electron transport	J:150206
	abnormal mitochondrial physiology	J:150206
	abnormal respiratory electron transport chain	J:150206
	normal behavior/neurological phenotype	J:150206
	normal cellular phenotype	J:150206
	decreased body weight	J:150206
	decreased dopamine level	J:150206
	decreased locomotor activity	J:150206
	normal endocrine/exocrine gland phenotype	J:150206
	extended life span	J:214065
	normal nervous system phenotype	J:150206
Pink1^{tm1b(EUCOMM)Wtsi}/Pink1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pink1^{tm1b(EUCOMM)Wtsi}/H	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased mean platelet volume	J:211773
Pink1^tm1Hbu/Pink1^tm1Hbu involves: 129S7/SvEvBrd * C57BL/6	abnormal mitochondrial physiology	J:169471
	decreased dopamine level	J:169471
	increased interleukin-1 beta secretion	J:169471
	increased interleukin-10 secretion	J:169471
	increased interleukin-12 secretion	J:169471
Pink1^tm1Hlw/Pink1^tm1Hlw involves: 129 * C57BL/6J	abnormal dopaminergic neuron morphology	J:175006
	abnormal neuron physiology	J:175006
	increased sensitivity to induced cell death	J:175006
	oxidative stress	J:175006
Pink1^tm1Lex/Pink1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal cellular respiration	J:148988
	abnormal cerebral cortex morphology	J:148903
	abnormal lysosome morphology	J:148903
	abnormal mitochondrial ATP synthesis coupled electron transport	J:148988
	abnormal nervous system electrophysiology	J:148988
	abnormal neuron physiology	J:148988
	increased neuron apoptosis	J:148903
Pink1^tm1Shn/Pink1^tm1Shn involves: 129S4/SvJae * C57BL/6	abnormal nervous system physiology	J:122728
	decreased dopamine level	J:122728
	reduced long-term depression	J:122728
	reduced long-term potentiation	J:122728
Pink1^tm1Vbae/Pink1^tm1Vbae involves: 129P2/OlaHsd * C57BL/6	abnormal cell physiology	J:182977
	abnormal mitochondrial morphology	J:182977
	abnormal mitochondrial physiology	J:182977
	normal cellular phenotype	J:182977
	oxidative stress	J:182977

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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