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Adgrg6 Gene Detail
Summary
  • Symbol
    Adgrg6
  • Name
    adhesion G protein-coupled receptor G6
  • Synonyms
    1190004A11Rik, DREG, Gpr126, LOC215798
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916151
    NCBI Gene: 215798
  • Gene Overview
    MyGene.info: ADGRG6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:14402583-14545179 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      142597 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 5.43 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADGRG6, adhesion G protein-coupled receptor G6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADGRG6, adhesion G protein-coupled receptor G6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APG1, DREG, GPR126, LCCS9, PR126, PS1TP2, VIGR
  • Links
    NCBI Gene ID: 57211
    neXtProt AC: NX_Q86SQ4
    UniProt: Q86SQ4

  • Chr Location
    6q24.2; chr6:142301919-142446266 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    5 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die during organogenesis and display signs of circulatory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059618 VEGA Gene Model | MGI Sequence Detail 142597 C57BL/6J ±  kb
    transcript OTTMUST00000146193 VEGA | MGI Sequence Detail 3582 Not Applicable  
    polypeptide OTTMUSP00000076149 VEGA | MGI Sequence Detail 1193 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1542 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000859 CUB domain
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR003910 GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR001759 Pentraxin-related
      IPR035914 Spermadhesin, CUB domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143604, MGI:2143793, MGI:2685068
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:237337 Mogha A, et al., Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. J Neurosci. 2016 Dec 07;36(49):12351-12367

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory