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Adgrg6 Gene Detail
Summary
  • Symbol
    Adgrg6
  • Name
    adhesion G protein-coupled receptor G6
  • Synonyms
    1190004A11Rik, DREG, Gpr126, LOC215798
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916151
    NCBI Gene: 215798
  • Gene Overview
    MyGene.info: ADGRG6
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:14402583-14545659 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 5.43 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1542 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916151
protein coding gene Chr10:14402583-14545723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017027
protein coding gene Chr10:11888932-12042176 (-)
A/J MGP_AJ_G0017005
protein coding gene Chr10:11411329-11552083 (-)
AKR/J MGP_AKRJ_G0016969
protein coding gene Chr10:11668422-11817947 (-)
BALB/cJ MGP_BALBcJ_G0016963
protein coding gene Chr10:11434045-11579020 (-)
C3H/HeJ MGP_C3HHeJ_G0016788
protein coding gene Chr10:11850219-11997594 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017425
protein coding gene Chr10:12179314-12327206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015130
protein coding gene Chr10:10658380-10796632 (-)
CAST/EiJ MGP_CASTEiJ_G0016370
protein coding gene Chr10:11723408-11876411 (-)
CBA/J MGP_CBAJ_G0016760
protein coding gene Chr10:12640508-12806653 (-)
DBA/2J MGP_DBA2J_G0016868
protein coding gene Chr10:11364492-11501333 (-)
FVB/NJ MGP_FVBNJ_G0016863
protein coding gene Chr10:11149860-11294350 (-)
LP/J MGP_LPJ_G0016943
protein coding gene Chr10:11716414-11866264 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016893
protein coding gene Chr10:12526852-12687438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017463
protein coding gene Chr10:11579444-11728186 (-)
PWK/PhJ MGP_PWKPhJ_G0016155
protein coding gene Chr10:11193395-11334092 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015938
protein coding gene Chr10:11735062-11877462 (-)
WSB/EiJ MGP_WSBEiJ_G0016432
protein coding gene Chr10:11634458-11789328 (-)



Homology
more
  • Human Ortholog
    ADGRG6, adhesion G protein-coupled receptor G6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADGRG6, adhesion G protein-coupled receptor G6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APG1, DREG, GPR126, LCCS9, PR126, PS1TP2, VIGR
  • Links
    NCBI Gene ID: 57211
    neXtProt AC: NX_Q86SQ4
    UniProt: Q86SQ4

  • Chr Location
    6q24.2; chr6:142301919-142446266 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    5 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die during organogenesis and display signs of circulatory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039116 Ensembl Gene Model | MGI Sequence Detail 143077 C57BL/6J ±  kb
    transcript ENSMUST00000208429 Ensembl | MGI Sequence Detail 4326 Not Applicable  
    polypeptide ENSMUSP00000146821 Ensembl | MGI Sequence Detail 1193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000859 CUB domain
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR003910 GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR001759 Pentraxin-related
      IPR035914 Spermadhesin, CUB domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143604, MGI:2143793, MGI:2685068
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:237337 Mogha A, et al., Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. J Neurosci. 2016 Dec 07;36(49):12351-12367

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory