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Gpr126
Gene Detail
 Symbol
Name
ID
Gpr126
G protein-coupled receptor 126
MGI:1916151
Synonyms 1190004A11Rik, DREG, LOC215798
Feature Type protein coding gene
Genetic Map
Chromosome 10
5.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:14402585-14545036 bp, - strand
From NCBI annotation of GRCm38

  142452 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: probable G protein-coupled receptor 126
Gene Tree: Gpr126

Human
homologs
Human Homolog GPR126, G protein-coupled receptor 126
NCBI Gene ID 57211
neXtProt AC  NX_Q86SQ4
Human Synonyms  APG1, DREG, PS1TP2, VIGR
Human Chr (Location)  6q24.1; chr6:142301919-142446266 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation die during organogenesis and display signs of circulatory failure.
 
Phenotype Images(1)
Interactions
Gpr126 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cell surface, cytoplasm, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (33)    Tissues (20)   
Theiler Stages: 10, 14, 16, 18, 23, 25, 28
Assay TypeResults
RNA in situ 8
Northern blot 1
RT-PCR 24
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(29) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039116 (Evidence)
Entrez Gene215798 (Evidence)
UniGene440142
DFCITC1586474, TC1598964
DoTSDT.487257
NIA Mouse Gene IndexU031554
Consensus CDS ProjectCCDS35848.1
International Mouse Knockout Project StatusGpr126
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 215798 NCBI Gene Model | MGI Sequence Detail 142452 C57BL/6J ±  kb
transcript NM_001002268 RefSeq | MGI Sequence Detail 6505 Not Specified 
polypeptide Q6F3F9 UniProt | EBI | MGI Sequence Detail 1165 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(1549 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR000859 CUB domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR003910 GPCR, family 2, orphan receptor, GPR56
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000203 GPS domain
Protein Ontology PR:000029514 G-protein coupled receptor 126
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204175 Mogha A, et al., Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013 Nov 13;33(46):17976-85
All references(38)
Other
accession IDs
MGI:2143604, MGI:2143793, MGI:2685068

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory