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Ak8
Gene Detail
Symbol

Name
ID
Ak8
adenylate kinase 8
MGI:1916120
Synonyms
1190002A17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:28700164-28813165 bp, + strand
From VEGA annotation of GRCm38

  113002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AK8
Gene Tree: Ak8

Human
homologs
AK8, adenylate kinase 8
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 158067
neXtProt AC: NX_Q96MA6

Human Synonyms: AK 8, C9orf98, DDX31

Human Chr (Location): 9q34.13; chr9:132725574-132878811 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap insertion exhibit mild hydrocephalus, dilation of the lateral brain ventricles and reduced size of the hippocampus.
 
Interactions
Ak8 interacts with 27 markers (Mir15a, Mir134, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process nucleobase-containing compound metabolic process, nucleoside diphosphate phosphorylation, ...
Component cytoplasm
Function adenylate kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ak8 ; ZFIN ak8    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011768 (Evidence)
Ensembl Gene Model ENSMUSG00000026807 (Evidence)
Entrez Gene 68870 (Evidence)
UniGene 273318
DFCI TC1582685
DoTS DT.40147900
NIA Mouse Gene Index U001551
EC 2.7.4.3, 2.7.4.6
Consensus CDS Project CCDS15846.1
International Mouse Phenotyping Consortium Status Ak8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011768 VEGA Gene Model | MGI Sequence Detail 113002 C57BL/6J ±  kb
transcript OTTMUST00000027604 VEGA | MGI Sequence Detail 1567 Not Applicable 
polypeptide OTTMUSP00000012544 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(16) UniProt(1)
Polymorphisms
SNPs within 2kb(353 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000850 Adenylate kinase
InterPro IPR007862 Adenylate kinase, active site lid domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000029119 adenylate kinase 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory