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Ak8 Gene Detail
Summary
  • Symbol
    Ak8
  • Name
    adenylate kinase 8
  • Synonyms
    1190002A17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916120
    NCBI Gene: 68870
Location & Maps
more
  • Sequence Map
    Chr2:28700164-28813165 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113002 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AK8, adenylate kinase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AK8, adenylate kinase 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AK 8, C9orf98, DDX31
  • Links
    NCBI Gene ID: 158067
    neXtProt AC: NX_Q96MA6

  • Chr Location
    9q34.13; chr9:132725574-132878811 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 17622
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AK8
  • Gene Tree
    Ak8
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    5
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a gene trap insertion exhibit mild hydrocephalus, dilation of the lateral brain ventricles and reduced size of the hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011768 VEGA Gene Model | MGI Sequence Detail 113002 C57BL/6J ±  kb
transcript OTTMUST00000027604 VEGA | MGI Sequence Detail 1567 Not Applicable  
polypeptide OTTMUSP00000012544 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    360 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222992 Vadnais ML, et al., Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Biol Reprod. 2014 Jun;90(6):128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory