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Ak8 Gene Detail
Summary
  • Symbol
    Ak8
  • Name
    adenylate kinase 8
  • Synonyms
    1190002A17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916120
    NCBI Gene: 68870
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28700164-28813165 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    360 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916120
protein coding gene Chr2:28698222-28813165 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025531
protein coding gene Chr2:26777372-26899110 (+)
A/J MGP_AJ_G0025508
protein coding gene Chr2:25753831-25870040 (+)
AKR/J MGP_AKRJ_G0025478
protein coding gene Chr2:26605754-26722309 (+)
BALB/cJ MGP_BALBcJ_G0025504
protein coding gene Chr2:25874584-25990633 (+)
C3H/HeJ MGP_C3HHeJ_G0025265
protein coding gene Chr2:26528191-26647602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025948
protein coding gene Chr2:27671691-27789320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023358
protein coding gene Chr2:24571215-24686757 (+)
CAST/EiJ MGP_CASTEiJ_G0024728
protein coding gene Chr2:26434112-26557838 (+)
CBA/J MGP_CBAJ_G0025243
protein coding gene Chr2:28600634-28737675 (+)
DBA/2J MGP_DBA2J_G0025376
protein coding gene Chr2:25564122-25678638 (+)
FVB/NJ MGP_FVBNJ_G0025338
protein coding gene Chr2:25351235-25470616 (+)
LP/J MGP_LPJ_G0025462
protein coding gene Chr2:26723537-26840230 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025369
protein coding gene Chr2:28626806-28746499 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026007
protein coding gene Chr2:26524999-26644487 (+)
PWK/PhJ MGP_PWKPhJ_G0024475
protein coding gene Chr2:25372692-25490693 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024275
protein coding gene Chr2:26655582-26775125 (+)
WSB/EiJ MGP_WSBEiJ_G0024797
protein coding gene Chr2:26659947-26777840 (+)



Homology
more
  • Human Ortholog
    AK8, adenylate kinase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AK8, adenylate kinase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AK 8, C9orf98, DDX31
  • Links
    NCBI Gene ID: 158067
    neXtProt AC: NX_Q96MA6
    UniProt: Q96MA6

  • Chr Location
    9q34.13; chr9:132725574-132878811 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17622
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AK8
  • Gene Tree
    Ak8
Human Diseases
more
  • Diseases
    1 with Ak8 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion exhibit mild hydrocephalus, dilation of the lateral brain ventricles and reduced size of the hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026807 Ensembl Gene Model | MGI Sequence Detail 113002 C57BL/6J ±  kb
transcript ENSMUST00000074156 Ensembl | MGI Sequence Detail 1567 Not Applicable  
polypeptide ENSMUSP00000073789 Ensembl | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Diseases 1
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222992 Vadnais ML, et al., Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Biol Reprod. 2014 Jun;90(6):128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory