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Prickle1
Gene Detail
 Symbol
Name
ID
Prickle1
prickle homolog 1 (Drosophila)
MGI:1916034
Synonyms 1110058P22Rik, b2b019Clo, mpk1
Feature Type protein coding gene
Genetic Map
Chromosome 15
47.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:93499114-93595891 bp, - strand
From VEGA annotation of GRCm38

  96778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Prickle1

Human
homologs
Human Homolog PRICKLE1, prickle homolog 1 (Drosophila)
NCBI Gene ID 144165
neXtProt AC  NX_Q96MT3
Human Synonyms  EPM1B, RILP
Human Chr (Location)  12q12; chr12:42458338-42589770 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRICKLE1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(3) Radiation induced(1) Targeted(5)
Genomic Mutations involving Prickle1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous null or point mutations result in decreased seizure threshold. Homozygous null mice display early embryonic lethality associated with altered epiblast apical-basal polarity, failed anterior migration of the distal visceral endoderm, and lack of mesoderm and primitive streak formation.
 
Human Diseases Modeled Using Mouse Prickle1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(10)
Interactions
Prickle1 interacts with 259 markers (Mir7-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell myoblast differentiation, ...
Component cytoplasm, cytosol, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (320)    Tissues (149)    Images (48)
Theiler Stages: 8, 9, 11, 12, 14, 17, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 320
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000021009 (Evidence)
Ensembl Gene ModelENSMUSG00000036158 (Evidence)
Entrez Gene106042 (Evidence)
DFCITC1575963, TC1664407, TC1671518, TC1706736
DoTSDT.101261671, DT.40179617, DT.531137, DT.55181641, DT.94286244, DT.94309737
NIA Mouse Gene IndexU036564
Consensus CDS ProjectCCDS27769.1
International Mouse Knockout Project StatusPrickle1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021009 VEGA Gene Model | MGI Sequence Detail 96778 C57BL/6J ±  kb
transcript OTTMUST00000049663 VEGA | MGI Sequence Detail 4085 Not Applicable 
polypeptide OTTMUSP00000023048 VEGA | MGI Sequence Detail 832 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(585 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010442 PET domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000013211 prickle-like protein 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205338 Kuss P, et al., Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014 Jan 1;385(1):83-93
All references(57)
Disease annotation references (1)
Other
accession IDs
MGI:2146210, MGI:5300247

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory