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Prickle1 Gene Detail
Summary
  • Symbol
    Prickle1
  • Name
    prickle planar cell polarity protein 1
  • Synonyms
    1110058P22Rik, b2b019Clo, mpk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916034
    NCBI Gene: 106042
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:93499114-93595891 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 47.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916034
protein coding gene Chr15:93499111-93596266 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022257
protein coding gene Chr15:94923986-95032933 (-)
A/J MGP_AJ_G0022216
protein coding gene Chr15:91252818-91351027 (-)
AKR/J MGP_AKRJ_G0022191
protein coding gene Chr15:93976107-94082712 (-)
BALB/cJ MGP_BALBcJ_G0022222
protein coding gene Chr15:91369441-91475636 (-)
C3H/HeJ MGP_C3HHeJ_G0021992
protein coding gene Chr15:93989451-94095904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022667
protein coding gene Chr15:98394093-98505998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020193
protein coding gene Chr15:87294082-87388391 (-)
CAST/EiJ MGP_CASTEiJ_G0021514
protein coding gene Chr15:94808356-94912982 (-)
CBA/J MGP_CBAJ_G0021959
protein coding gene Chr15:101715427-101831481 (-)
DBA/2J MGP_DBA2J_G0022086
protein coding gene Chr15:90677821-90777470 (-)
FVB/NJ MGP_FVBNJ_G0022065
protein coding gene Chr15:89695125-89792529 (-)
LP/J MGP_LPJ_G0022157
protein coding gene Chr15:95026849-95129949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022085
protein coding gene Chr15:106054868-106160722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022682
protein coding gene Chr15:94062774-94170329 (-)
PWK/PhJ MGP_PWKPhJ_G0021255
protein coding gene Chr15:90728571-90829604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021089
protein coding gene Chr15:93796616-93900205 (-)
WSB/EiJ MGP_WSBEiJ_G0021563
protein coding gene Chr15:94550639-94664216 (-)



Homology
more
  • Human Ortholog
    PRICKLE1, prickle planar cell polarity protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRICKLE1, prickle planar cell polarity protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPM1B, RILP
  • Links
    NCBI Gene ID: 144165
    neXtProt AC: NX_Q96MT3
    UniProt: Q96MT3

  • Chr Location
    12q12; chr12:42458338-42589770 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Prickle1 mouse models; 1 with human PRICKLE1 associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 7 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Heterozygous null or point mutations result in decreased seizure threshold. Homozygous null mice display early embryonic lethality associated with altered epiblast apical-basal polarity, failed anterior migration of the distal visceral endoderm, and lackof mesoderm and primitive streak formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036158 Ensembl Gene Model | MGI Sequence Detail 96778 C57BL/6J ±  kb
    transcript ENSMUST00000109255 Ensembl | MGI Sequence Detail 4144 Not Applicable  
    polypeptide ENSMUSP00000104878 Ensembl | MGI Sequence Detail 832 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2146210, MGI:5300247
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 30
      Diseases 3
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:264113 Lopez-Escobar B, et al., The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory