Phenotypes Associated with This Genotype

Genotype
MGI:6890373

• Allelic Composition: Prickle1^em1Yzou/Prickle1^em1Yzou
• Genetic Background: C57BL/6-Prickle1^em1Yzou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:321396 )

• in the novel object recognition task, mice do not display strong preference to the novel object as shown by lower discrimination index, indicating impaired novel object recognition

• however, mice show no differences from wild-type mice in spatial memory

abnormal social investigation ( J:321396 )

• mice show deficits in sociability in the three-chamber social interaction task, spending less time engaging in social behavior

• however, mice show normal social recognition memory in the three-chamber social novelty task

• mice show no differences in anxiety in the open field arena, elevated plus maze, or light-dark transition tasks

nervous system

abnormal excitatory synapse morphology ( J:321396 )

• mice show a 20% reduction in the number of excitatory glutamatergic synapses in the hippocampus at P14 and 35% reduction in adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:321396