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Targeted Allele Detail
Symbol: Prickle1tm1.2Asw
Name: prickle planar cell polarity protein 1; targeted mutation 1.2, Anand Swaroop
MGI ID: MGI:5645931
Synonyms: Prickle1b, Prickle1EYFP
Gene: Prickle1  Location: Chr15:93396995-93493772 bp, - strand  Genetic Position: Chr15, 47.69 cM
Alliance: Prickle1tm1.2Asw page
Germline Transmission:  Earliest citation of germline transmission: J:213772
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT site, splice acceptor, EYFP, loxP site, neomycin resistance (neo) cassette, FRT site and loxP site were inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette and exon 2. Immunoblot analysis confirmed the absence of expression in homozygous mice. (J:213772)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 30 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prickle1 Mutation:  28 strains or lines available
Original:  J:213772 Liu C, et al., Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3(9):861-70
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory