Chn1
Gene Detail

Symbol Name ID

Chn1 chimerin (chimaerin) 1 MGI:1915674

Synonyms

0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, alpha1 chimaerin, alpha2 chimaerin, ARHGAP2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

43.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:73610660-73775346 bp, - strand From VEGA annotation of GRCm38   164687 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31056  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: chimaerin
Gene Tree: Chn1

Human homologs

Human Homolog		CHN1, chimerin 1
NCBI Gene ID		1123
neXtProt AC		NX_P15882
Human Synonyms		ARHGAP2, CHN, DURS2, NC, RHOGAP2
Human Chr (Location)		2q31.1; chr2:175664042-175870107 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHN1

Alleles and phenotypes

All alleles(22) : Targeted(5) Gene trapped(16) Spontaneous(1)
 

Mice homologous for a null allele exhibit transient postnatal size reduction, abnormal gait and abnormal innervation of the spinal cord.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	ephrin receptor signaling pathway, intracellular signal transduction, ...
Component	intracellular
Function	ephrin receptor binding, GTPase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 24, 26, 28

Assay Type	Results
RNA in situ	45

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000013428 (Evidence)
Ensembl Gene Model	ENSMUSG00000056486 (Evidence)
Entrez Gene	108699 (Evidence)
DFCI	TC1572031, TC1585629, TC1590484, TC1620077
DoTS	DT.101387327, DT.40135712, DT.527887, DT.94265900, DT.94265904
Consensus CDS Project	CCDS16133.1, CCDS38145.1, CCDS50607.1, CCDS50608.1
International Mouse Knockout Project Status	Chn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013428	VEGA Gene Model | MGI Sequence Detail	164687	C57BL/6J
transcript	OTTMUST00000032446	VEGA | MGI Sequence Detail	4050	Not Applicable
polypeptide	OTTMUSP00000014414	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(90) RefSeq(10) UniProt(9)

Polymorphisms

SNPs(158 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR017356	N-chimaerin
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000005442	N-chimaerin

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:180317 Ip JP, et al., alpha2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat Neurosci. 2012 Jan;15(1):39-47
All references(39)

Other accession IDs

MGI:1915574, MGI:1923974, MGI:1925592, MGI:2138925