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Chn1 Gene Detail
Summary
  • Symbol
    Chn1
  • Name
    chimerin 1
  • Synonyms
    0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, alpha1 chimaerin, alpha2 chimaerin, ARHGAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915674
    NCBI Gene: 108699
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73610660-73775346 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915674
protein coding gene Chr2:73610660-73775367 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025840
protein coding gene Chr2:73900614-74063128 (-)
A/J MGP_AJ_G0025818
protein coding gene Chr2:70995121-71157196 (-)
AKR/J MGP_AKRJ_G0025786
protein coding gene Chr2:72944040-73099727 (-)
BALB/cJ MGP_BALBcJ_G0025812
protein coding gene Chr2:71185532-71348477 (-)
C3H/HeJ MGP_C3HHeJ_G0025572
protein coding gene Chr2:73129825-73296360 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026259
protein coding gene Chr2:76105554-76267545 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023662
protein coding gene Chr2:68427126-68584825 (-)
CAST/EiJ MGP_CASTEiJ_G0025036
protein coding gene Chr2:73410207-73575085 (-)
CBA/J MGP_CBAJ_G0025553
protein coding gene Chr2:78873486-79051616 (-)
DBA/2J MGP_DBA2J_G0025684
protein coding gene Chr2:70592509-70750339 (-)
FVB/NJ MGP_FVBNJ_G0025646
protein coding gene Chr2:70006090-70167416 (-)
LP/J MGP_LPJ_G0025772
protein coding gene Chr2:73772575-73938521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025677
protein coding gene Chr2:80792032-80962303 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026316
protein coding gene Chr2:73033644-73195675 (-)
PWK/PhJ MGP_PWKPhJ_G0024777
protein coding gene Chr2:70521796-70679521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024585
protein coding gene Chr2:73267834-73425206 (-)
WSB/EiJ MGP_WSBEiJ_G0025104
protein coding gene Chr2:73487425-73652184 (-)



Homology
more
  • Human Ortholog
    CHN1, chimerin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CHN1, chimerin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGAP2, CHN, DURS2, NC, RHOGAP2
  • Links
    NCBI Gene ID: 1123
    neXtProt AC: NX_P15882
    UniProt: P15882

  • Chr Location
    2q31.1; chr2:174799314-175005379 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CHN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 9 alleles in 9 genetic backgrounds
    3 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homologous for a null allele exhibit transient postnatal size reduction, abnormal gait and abnormal innervation of the spinal cord.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056486 Ensembl Gene Model | MGI Sequence Detail 164687 C57BL/6J ±  kb
    transcript ENSMUST00000112024 Ensembl | MGI Sequence Detail 4050 Not Applicable  
    polypeptide ENSMUSP00000107655 Ensembl | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915574, MGI:1923974, MGI:1925592, MGI:2138925
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 29
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory