About   Help   FAQ
Chn1 Gene Detail
Summary
  • Symbol
    Chn1
  • Name
    chimerin 1
  • Synonyms
    0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, alpha1 chimaerin, alpha2 chimaerin, ARHGAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915674
    NCBI Gene: 108699
Location & Maps
more
  • Sequence Map
    Chr2:73610660-73775346 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      164687 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CHN1, chimerin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CHN1, chimerin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHGAP2, CHN, DURS2, NC, RHOGAP2
  • Links
    NCBI Gene ID: 1123
    neXtProt AC: NX_P15882

  • Chr Location
    2q31.1; chr2:174799314-175005379 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CHN1 associations

Human Disease Mouse Models
       Duane Retraction Syndrome 2; DURS2   OMIM: 604356
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 8 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    16
  • Spontaneous
    1
  • Targeted
    17
  • Genomic Mutations
    7 involving Chn1
  • Incidental Mutations
Mice homologous for a null allele exhibit transient postnatal size reduction, abnormal gait and abnormal innervation of the spinal cord.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013428 VEGA Gene Model | MGI Sequence Detail 164687 C57BL/6J ±  kb
transcript OTTMUST00000032446 VEGA | MGI Sequence Detail 4050 Not Applicable  
polypeptide OTTMUSP00000014414 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    808 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 97
    cDNA 97

    Microarray probesets 7
Other
Accession IDs
less
MGI:1915574, MGI:1923974, MGI:1925592, MGI:2138925
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:219882 Kao TJ, et al., alpha2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles. J Neurosci. 2015 Feb 11;35(6):2344-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory