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Chn1
Gene Detail
 Symbol
Name
ID
Chn1
chimerin 1
MGI:1915674
Synonyms 0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, alpha1 chimaerin, alpha2 chimaerin, ARHGAP2
Feature Type protein coding gene
Genetic Map
Chromosome 2
43.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:73610660-73775346 bp, - strand
From VEGA annotation of GRCm38

  164687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: chimaerin
Gene Tree: Chn1

Human
homologs
Human Homolog CHN1, chimerin 1
NCBI Gene ID 1123
neXtProt AC  NX_P15882
Human Synonyms  ARHGAP2, CHN, DURS2, NC, RHOGAP2
Human Chr (Location)  2q31.1; chr2:174799314-175005379 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(16) Spontaneous(1) Targeted(9)
Genomic Mutations involving Chn1 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homologous for a null allele exhibit transient postnatal size reduction, abnormal gait and abnormal innervation of the spinal cord.
 
Interactions
Chn1 interacts with 309 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process ephrin receptor signaling pathway, intracellular signal transduction, ...
Component intracellular
Function ephrin receptor binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 24, 26, 28
Assay TypeResults
RNA in situ 45
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(97)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000013428 (Evidence)
Ensembl Gene ModelENSMUSG00000056486 (Evidence)
Entrez Gene108699 (Evidence)
UniGene257073
DFCITC1572031, TC1585629, TC1590484, TC1620077
DoTSDT.101387327, DT.40135712, DT.527887, DT.94265900, DT.94265904
Consensus CDS ProjectCCDS16133.1, CCDS38145.1, CCDS50607.1, CCDS50608.1
International Mouse Knockout Project StatusChn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013428 VEGA Gene Model | MGI Sequence Detail 164687 C57BL/6J ±  kb
transcript OTTMUST00000032446 VEGA | MGI Sequence Detail 4050 Not Applicable 
polypeptide OTTMUSP00000014414 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(20) UniProt(9)
Polymorphisms SNPs within 2kb(811 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017356 N-chimaerin
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR000980 SH2 domain
Protein Ontology PR:000005442 N-chimaerin
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209606 Borgius L, et al., Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits. J Neurosci. 2014 Mar 12;34(11):3841-53
All references(41)
Other
accession IDs
MGI:1915574, MGI:1923974, MGI:1925592, MGI:2138925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory