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Mto1 Gene Detail
Summary
  • Symbol
    Mto1
  • Name
    mitochondrial tRNA translation optimization 1
  • Synonyms
    2310039H01Rik, 5730419A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915541
    NCBI Gene: 68291
  • Gene Overview
    MyGene.info: MTO1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78447870-78474165 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915541
protein coding gene Chr9:78447870-78475348 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035071
protein coding gene Chr9:78955226-78991324 (+)
A/J MGP_AJ_G0035052
protein coding gene Chr9:76229053-76260665 (+)
AKR/J MGP_AKRJ_G0034980
protein coding gene Chr9:78033296-78061237 (+)
BALB/cJ MGP_BALBcJ_G0035040
protein coding gene Chr9:75888931-75917345 (+)
C3H/HeJ MGP_C3HHeJ_G0034752
protein coding gene Chr9:78552502-78581513 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035561
protein coding gene Chr9:81085934-81122695 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032470
protein coding gene Chr9:75458885-75482121 (+)
CAST/EiJ MGP_CASTEiJ_G0034066
protein coding gene Chr9:78701557-78864837 (+)
CBA/J MGP_CBAJ_G0034725
protein coding gene Chr9:83946179-83980251 (+)
DBA/2J MGP_DBA2J_G0034883
protein coding gene Chr9:75869487-75901334 (+)
FVB/NJ MGP_FVBNJ_G0034826
protein coding gene Chr9:75100665-75129147 (+)
LP/J MGP_LPJ_G0034964
protein coding gene Chr9:79183273-79210588 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034868
protein coding gene Chr9:85133652-85168368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035584
protein coding gene Chr9:78201809-78231610 (+)
PWK/PhJ MGP_PWKPhJ_G0033773
protein coding gene Chr9:76065438-76090061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033610
protein coding gene Chr9:78401652-78432899 (+)
WSB/EiJ MGP_WSBEiJ_G0034186
protein coding gene Chr9:78148043-78177551 (+)



Homology
more
  • Human Ortholog
    MTO1, mitochondrial tRNA translation optimization 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MTO1, mitochondrial tRNA translation optimization 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-02, COXPD10
  • Links
    NCBI Gene ID: 25821
    neXtProt AC: NX_Q9Y2Z2
    UniProt: Q9Y2Z2

  • Chr Location
    6q13; chr6:73461727-73501456 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mto1 mouse models; 1 with human MTO1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a hypomorphic allele show bradycardia, cardiomyopathy, worsening of arrhythmias during induction and reversal of anesthesia, and mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68291 NCBI Gene Model | MGI Sequence Detail 26296 C57BL/6J ±  kb
transcript NM_026658 RefSeq | MGI Sequence Detail 2364 C57BL/6  
polypeptide Q923Z3 UniProt | EBI | MGI Sequence Detail 669 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR036188 FAD/NAD(P)-binding domain superfamily
    IPR026904 GidA associated domain 3
    IPR020595 MnmG-related, conserved site
    IPR004416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
    IPR002218 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917779
References
more
  • Summaries
    All 44
    Diseases 1
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:220604 Tischner C, et al., MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention. Hum Mol Genet. 2015 Apr 15;24(8):2247-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory