About   Help   FAQ
Mto1Gt(G019A03)Wrst
Gene trapped Allele Detail
Summary
Symbol: Mto1Gt(G019A03)Wrst
Name: mitochondrial tRNA translation optimization 1; gene trap G019A03, German Gene Trap Consortium
MGI ID: MGI:4336382
Gene: Mto1  Location: Chr9:78355372-78381447 bp, + strand  Genetic Position: Chr9, 43.65 cM, cytoband E1
Alliance: Mto1Gt(G019A03)Wrst page
Mutation
origin
Mutant Cell Line:  G019A03
Germline Transmission:  Earliest citation of germline transmission: J:223246
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector     Vector: U3CEO     Vector Type: secretory trap
 
Mutation detailsTrapped gene association determined by genome coordinate overlap and strand. The gene trap vector U3CEO inserted into intron 6 of Mto1. Quantitative RT-PCR analysis of mRNA levels in heart from homozygotes indicate a 63% reduction compared to controls, indicating this is a hypomorphic allele. (J:223246)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mto1 Mutation:  37 strains or lines available
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory