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Tubb4b
Gene Detail
Symbol

Name
ID
Tubb4b
tubulin, beta 4B class IVB
MGI:1915472
Synonyms
4930542G03Rik, MGC:28623, MGC:6713, Tubb2c
Feature Type
protein coding gene
Genetic Map
Chromosome 2
17.08 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:25222160-25224702 bp, - strand
From VEGA annotation of GRCm38

  2543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tubb4b

Human
homologs
Human Homolog TUBB4B, tubulin, beta 4B class IVb
NCBI Gene ID 10383
neXtProt AC  NX_P68371
Human Synonyms  Beta2, TUBB2, TUBB2C
Human Chr (Location)  9q34; chr9:137241259-137243707 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Interactions
Tubb4b interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process GTP catabolic process, microtubule-based process, ...
Component cytoplasm, cytoskeleton, ...
Function double-stranded RNA binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(13)
External Resources: GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000011806 (Evidence)
Ensembl Gene ModelENSMUSG00000036752 (Evidence)
Entrez Gene227613 (Evidence)
DFCITC1573768, TC1751239
NIA Mouse Gene IndexU022378, U049470, U123407
Consensus CDS ProjectCCDS15753.1
International Mouse Knockout Project StatusTubb4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011806 VEGA Gene Model | MGI Sequence Detail 2543 C57BL/6J ±  kb
transcript OTTMUST00000027720 VEGA | MGI Sequence Detail 1598 Not Applicable 
polypeptide OTTMUSP00000012597 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016818 tubulin beta-4B chain
References
(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:201321 Copley CO, et al., Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci. 2013 Aug 28;33(35):14001-16
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory