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Tubb4b Gene Detail
Summary
  • Symbol
    Tubb4b
  • Name
    tubulin, beta 4B class IVB
  • Synonyms
    4930542G03Rik, MGC:28623, MGC:6713, Tubb2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915472
    NCBI Gene: 227613
  • Gene Overview
    MyGene.info: TUBB4B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25222160-25224702 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.08 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915472
protein coding gene Chr2:25222158-25224702 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025426
protein coding gene Chr2:23087360-23091108 (-)
A/J MGP_AJ_G0025403
protein coding gene Chr2:22199280-22200411 (-)
AKR/J MGP_AKRJ_G0025373
protein coding gene Chr2:22941505-22945938 (-)
BALB/cJ MGP_BALBcJ_G0025399
protein coding gene Chr2:22309917-22313458 (-)
C3H/HeJ MGP_C3HHeJ_G0025160
protein coding gene Chr2:22870729-22873244 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025843
protein coding gene Chr2:23819925-23823971 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023254
protein coding gene Chr2:21119542-21122076 (-)
CAST/EiJ MGP_CASTEiJ_G0024623
protein coding gene Chr2:22754450-22756708 (-)
CBA/J MGP_CBAJ_G0025138
protein coding gene Chr2:24658608-24660877 (-)
DBA/2J MGP_DBA2J_G0025271
protein coding gene Chr2:22043466-22045644 (-)
FVB/NJ MGP_FVBNJ_G0025233
protein coding gene Chr2:21782959-21785503 (-)
LP/J MGP_LPJ_G0025357
protein coding gene Chr2:23032323-23035274 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025264
protein coding gene Chr2:24860972-24863716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025902
protein coding gene Chr2:22887743-22890541 (-)
PWK/PhJ MGP_PWKPhJ_G0024371
protein coding gene Chr2:21856795-21857925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024171
protein coding gene Chr2:23044828-23048113 (-)
WSB/EiJ MGP_WSBEiJ_G0024692
protein coding gene Chr2:22962448-22963579 (-)



Homology
more
  • Human Ortholog
    TUBB4B, tubulin beta 4B class IVb
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TUBB4B, tubulin beta 4B class IVb
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Beta2, LCAEOD, TUBB2, TUBB2C
  • Links
    NCBI Gene ID: 10383
    neXtProt AC: NX_P68371
    UniProt: P68371

  • Chr Location
    9q34.3; chr9:137241259-137243707 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68504
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TUBB4B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036752 Ensembl Gene Model | MGI Sequence Detail 2543 C57BL/6J ±  kb
transcript ENSMUST00000043584 Ensembl | MGI Sequence Detail 1598 Not Applicable  
polypeptide ENSMUSP00000042342 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 7
References
more
  • Summaries
    All 45
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
  • Latest
    J:245768 Landry-Truchon K, et al., HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 01;144(19):3547-3561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory