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Tubb4b
Gene Detail
Symbol

Name
ID
Tubb4b
tubulin, beta 4B class IVB
MGI:1915472
Synonyms
4930542G03Rik, MGC:28623, MGC:6713, Tubb2c
Feature Type
protein coding gene
Genetic Map
Chromosome 2
17.08 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:25222160-25224702 bp, - strand
From VEGA annotation of GRCm38

  2543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TUBB4B
Gene Tree: Tubb4b

Human
homologs
TUBB4B, tubulin, beta 4B class IVb
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10383
neXtProt AC: NX_P68371

Human Synonyms: Beta2, TUBB2, TUBB2C

Human Chr (Location): 9q34; chr9:137241259-137243707 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Interactions
Tubb4b interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process microtubule-based process, protein polymerization
Component cytoplasm, cytoskeleton, ...
Function double-stranded RNA binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(13)
Other mouse links: GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tubb4b    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000011806 (Evidence)
Ensembl Gene Model ENSMUSG00000036752 (Evidence)
Entrez Gene 227613 (Evidence)
DFCI TC1751239, TC1573768
NIA Mouse Gene Index U123407, U022378, U049470
Consensus CDS Project CCDS15753.1
International Mouse Phenotyping Consortium Status Tubb4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011806 VEGA Gene Model | MGI Sequence Detail 2543 C57BL/6J ±  kb
transcript OTTMUST00000027720 VEGA | MGI Sequence Detail 1598 Not Applicable 
polypeptide OTTMUSP00000012597 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016818 tubulin beta-4B chain
References
(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:201321 Copley CO, et al., Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci. 2013 Aug 28;33(35):14001-16
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory