Mfn1 MGI Mouse Gene Detail - MGI:1914664

Symbol

Mfn1
Name

mitofusin 1
Synonyms

2310002F04Rik, 6330416C07Rik, D3Ertd265e, HR2

Feature Type

protein coding gene
IDs

MGI:1914664
NCBI Gene: 67414
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:32583614-32633388 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.75 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

1361 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914664	protein coding gene	Chr3:32583594-32633388 (+)
129S1/SvImJ	ENSMUSG00200023519	protein coding gene	Chr3:29320522-29368279 (+)
A/J	ENSMUSG00195019655	protein coding gene	Chr3:29310971-29358766 (+)
AKR/J	ENSMUSG00220008219	protein coding gene	Chr3:29347214-29394940 (+)
BALB/cJ	ENSMUSG00180032514	protein coding gene	Chr3:29436406-29484091 (+)
C3H/HeJ	ENSMUSG00175026933	protein coding gene	Chr3:29303819-29351600 (+)
C57BL/6NJ	ENSMUSG00215010205	protein coding gene	Chr3:29710448-29758139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024918	protein coding gene	Chr3:27543768-27593761 (+)
CAST/EiJ	ENSTCUG00005023561	protein coding gene	Chr3:29209843-29256983 (+)
CBA/J	ENSMUSG00210033450	protein coding gene	Chr3:29389803-29437582 (+)
DBA/2J	ENSMUSG00185008887	protein coding gene	Chr3:29642051-29689777 (+)
FVB/NJ	ENSMUSG00205007037	protein coding gene	Chr3:28827810-28875536 (+)
JF1/MsJ	ENSUMUG00000002756	protein coding gene	Chr3:29084363-29132694 (+)
LP/J	ENSMUSG00230019049	protein coding gene	Chr3:31567034-31614786 (+)
NOD/ShiLtJ	ENSMUSG00190027236	protein coding gene	Chr3:29634896-29682608 (+)
NZO/HlLtJ	ENSMUSG00225006566	protein coding gene	Chr3:34185010-34232761 (+)
PWK/PhJ	ENSLUMG00010034020	protein coding gene	Chr3:29128095-29175751 (+)
SPRET/EiJ	ENSMSPG00010023688	protein coding gene	Chr3:29465921-29516659 (+)
WSB/EiJ	ENSIUOG00005033564	protein coding gene	Chr3:29635812-29683411 (+)

Human Ortholog

MFN1, mitofusin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MFN1, mitofusin 1
Synonyms

hfzo1, hfzo2
Links

HGNC:18262

NCBI Gene ID: 55669

UniProt: Q8IWA4
Chr Location

3q26.33; chr3:179346952-179394940 (+) GRCh38

MGI Vertebrate Homology

Mfn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MFN1
Gene Tree

Mfn1

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References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 4 alleles in 7 genetic backgrounds
26 phenotypes from multigenic genotypes
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

5
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Mfn1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die in mid gestation. Structural and functional abnormalities of mitochondria are reported.

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All GO Annotations

58
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

621
Tissues

11
cDNA Data

14
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mfn1

ZFIN mfn1b

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All Sequences

71
RefSeq

3
UniProt

5
CCDS

CCDS17296.1

Ensembl

ENSMUSG00000027668 (Evidence)
NCBI Gene

67414

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027668	Ensembl Gene Model \| MGI Sequence Detail	49775	C57BL/6J	± kb
transcript	ENSMUST00000091257	Ensembl \| MGI Sequence Detail	4562	Not Applicable
polypeptide	ENSMUSP00000088801	Ensembl \| MGI Sequence Detail	741	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010369 mitofusin-1

(term hierarchy)
PDB

1T3J
EC

3.6.5.-
InterPro Domains

IPR045063 Dynamin, N-terminal

IPR030381 Dynamin-type guanine nucleotide-binding (G) domain

IPR006884 Fzo/mitofusin HR2 domain

IPR027094 Mitofusin family

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 21

Genomic 2

cDNA 14

Primer pair 5

Antibodies 3

Microarray probesets 9

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MGI:1098715, MGI:1916768

Summaries

All 180

Developmental Gene Expression 18

Diseases 1

Gene Ontology 16

Phenotypes 77
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:387864 Landowski M, et al., Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells. Front Cell Dev Biol. 2026;14:1724328

TSS for Mfn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28756	Chr3:32583601-32583676 (+)	25 bp
Tssr28757	Chr3:32583681-32583692 (+)	73 bp
Tssr28758	Chr3:32583706-32583709 (+)	94 bp
Tssr28759	Chr3:32583728-32583777 (+)	139 bp
Tssr28760	Chr3:32583787-32583792 (+)	176 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24