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Mfn1
Gene Detail
Symbol

Name
ID
Mfn1
mitofusin 1
MGI:1914664
Synonyms
2310002F04Rik, 6330416C07Rik, D3Ertd265e, HR2
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.75 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:32529465-32579239 bp, + strand
From VEGA annotation of GRCm38

  49775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MFN1
Gene Tree: Mfn1

Human
homologs
MFN1, mitofusin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55669
neXtProt AC: NX_Q8IWA4

Human Synonyms: hfzo1, hfzo2

Human Chr (Location): 3q26.33; chr3:179347692-179393226 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die in mid gestation. Structural and functional abnormalities of mitochondria are reported.
 
Interactions
Mfn1 interacts with 254 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process mitochondrial fusion, multicellular organismal development
Component integral component of membrane, membrane, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 6
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mfn1 ; ZFIN mfn1b    NEW 
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000027816 (Evidence)
Ensembl Gene Model ENSMUSG00000027668 (Evidence)
Entrez Gene 67414 (Evidence)
DFCI TC1575224, TC1624501, TC1731734, TC1698502
DoTS DT.94306591, DT.101330540, DT.91296667, DT.101391962, DT.534601, DT.101391963, DT.97383354
NIA Mouse Gene Index U003129
EC 3.6.5.-
PDB 1T3J
Consensus CDS Project CCDS17296.1
International Mouse Phenotyping Consortium Status Mfn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027816 VEGA Gene Model | MGI Sequence Detail 49775 C57BL/6J ±  kb
transcript OTTMUST00000068847 VEGA | MGI Sequence Detail 4562 Not Applicable 
polypeptide OTTMUSP00000034887 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006884 Fzo/mitofusin HR2 domain
InterPro IPR027088 Mitofusin-1
InterPro IPR027094 Mitofusin family
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010369 mitofusin-1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:219969 Song M, et al., Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015 Feb 3;21(2):273-85
All references(66)
Other
accession IDs
MGI:1098715, MGI:1916768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory