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Mfn1
Gene Detail
Symbol

Name
ID
Mfn1
mitofusin 1
MGI:1914664
Synonyms
2310002F04Rik, 6330416C07Rik, D3Ertd265e, HR2
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.75 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:32529465-32579239 bp, + strand
From VEGA annotation of GRCm38

  49775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mfn1

Human
homologs
Human Homolog MFN1, mitofusin 1
NCBI Gene ID 55669
neXtProt AC  NX_Q8IWA4
Human Synonyms  hfzo1, hfzo2
Human Chr (Location)  3q26.33; chr3:179347692-179393226 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die in mid gestation. Structural and functional abnormalities of mitochondria are reported.
 
Interactions
Mfn1 interacts with 254 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process GTP catabolic process, mitochondrial fusion, ...
Component integral component of membrane, membrane, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 6
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000027816 (Evidence)
Ensembl Gene ModelENSMUSG00000027668 (Evidence)
Entrez Gene67414 (Evidence)
DFCITC1575224, TC1624501, TC1698502, TC1731734
DoTSDT.101330540, DT.101391962, DT.101391963, DT.534601, DT.91296667, DT.94306591, DT.97383354
NIA Mouse Gene IndexU003129
EC3.6.5.-
PDB1T3J
Consensus CDS ProjectCCDS17296.1
International Mouse Knockout Project StatusMfn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027816 VEGA Gene Model | MGI Sequence Detail 49775 C57BL/6J ±  kb
transcript OTTMUST00000069323 VEGA | MGI Sequence Detail 2789 Not Applicable 
polypeptide OTTMUSP00000035188 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR006884 Fzo/mitofusin HR2 domain
InterPro IPR027088 Mitofusin-1
InterPro IPR027094 Mitofusin family
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010369 mitofusin-1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:211366 Yue W, et al., A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014 Apr;24(4):482-96
All references(64)
Other
accession IDs
MGI:1098715, MGI:1916768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory