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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mfn1
mitofusin 1
MGI:1914664
21 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
no abnormal phenotype detected J:132329
Mfn1em1(IMPC)Hmgu/Mfn1em1(IMPC)Hmgu
C57BL/6NCrl-Mfn1em1(IMPC)Hmgu/Ieg
preweaning lethality, complete penetrance J:211773
Mfn1tm1.1Arte/Mfn1tm1.1Arte
Slc6a3tm1(cre)Lrsn/Slc6a3+
involves: 129S1/Sv * 129X1/SvJ
no abnormal phenotype detected J:188337
Mfn1tm1Dcc/Mfn1tm1Dcc
involves: 129S/SvEv
abnormal mitochondrial morphology J:81438
abnormal mitochondrial physiology J:81438
decreased embryo size J:81438
embryonic growth retardation J:81438
embryonic lethality during organogenesis, incomplete penetrance J:81438
Mfn1tm1Dcc/Mfn1tm2Dcc
involves: 129 * 129S4/SvJaeSor * Black Swiss
abnormal mitochondrial morphology J:132329
Mfn1tm1Dcc/Mfn1tm2Dcc
Tg(EIIa-cre)C5379Lmgd/0
involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N
prenatal lethality, complete penetrance J:132329
Mfn1tm2Dcc/Mfn1tm2Dcc
Tg(Stra8-icre)1Reb/0
involves: 129 * C57BL/6J * FVB/NJ
abnormal male germ cell morphology J:305430
abnormal male germ cell physiology J:305430
abnormal mitochondrial ATP synthesis coupled electron transport J:305430
abnormal mitochondrial morphology J:305430
abnormal spermatogenesis J:305430
normal cellular phenotype J:305430
decreased testis weight J:305430
increased mitochondrial DNA content J:305430
increased mitochondrial fission J:305430
male infertility J:305430
oligozoospermia J:305430
seminiferous tubule degeneration J:305430
small epididymis J:305430
small testis J:305430

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory