Mfn1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mfn1
mitofusin 1
MGI:1914664

23 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1.1(CAG-COX8A/Dendra2)Dcc}/Gt(ROSA)26Sor⁺ Mfn1^tm2Dcc/Mfn1^tm2Dcc Slc6a3^{tm1.1(cre)Bkmn}/Slc6a3⁺ involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J	no abnormal phenotype detected	J:188347
Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	neonatal lethality, complete penetrance	J:132329
Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2⁺ involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	neonatal lethality, complete penetrance	J:132329
Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm2Dcc/Mfn1⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	decreased body size	J:132329
	impaired limb coordination	J:132329
	impaired righting response	J:132329
	neonatal lethality, incomplete penetrance	J:132329
	postnatal lethality, complete penetrance	J:132329
Mfn1^tm1Dcc/Mfn1^tm1Dcc Mfn2^tm1Dcc/Mfn2^tm1Dcc involves: 129S/SvEv	prenatal lethality	J:81438
Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0 involves: 129 * 129S4/SvJaeSor * Black Swiss	abnormal Purkinje cell dendrite morphology	J:132329
	abnormal respiratory electron transport chain	J:132329
	Purkinje cell degeneration	J:132329
Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2⁺ involves: 129 * 129S4/SvJaeSor * Black Swiss	no abnormal phenotype detected	J:132329
Mfn1^tm2Dcc/Mfn1^tm2Dcc Mfn2^tm3Dcc/Mfn2^tm3Dcc Tg(Stra8-icre)1Reb/0 involves: 129 * C57BL/6J * FVB/NJ	abnormal mitochondrial morphology	J:305430
	abnormal spermatid morphology	J:305430
	abnormal spermatocyte morphology	J:305430
	abnormal spermatogenesis	J:305430
	arrest of male meiosis	J:305430
	decreased male germ cell number	J:305430
	decreased testis weight	J:305430
	male infertility	J:305430
	seminiferous tubule degeneration	J:305430
	small epididymis	J:305430
	small seminiferous tubules	J:305430
	small testis	J:305430

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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