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Qprt Gene Detail
Summary
  • Symbol
    Qprt
  • Name
    quinolinate phosphoribosyltransferase
  • Synonyms
    2410027J01Rik, nicotinate-nucleotide pyrophosphorylase, QPRTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914625
    NCBI Gene: 67375
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126706942-126721201 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914625
 protein coding gene Chr7:126706286-126721398 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033021
 protein coding gene Chr7:131426572-131442724 (-)
A/J MGP_AJ_G0033004
 protein coding gene Chr7:127936756-127951715 (-)
AKR/J MGP_AKRJ_G0032936
 protein coding gene Chr7:131180241-131196717 (-)
BALB/cJ MGP_BALBcJ_G0033009
 protein coding gene Chr7:127599480-127614435 (-)
C3H/HeJ MGP_C3HHeJ_G0032719
 protein coding gene Chr7:131112949-131129656 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033515
 protein coding gene Chr7:136531730-136546666 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030487
 protein coding gene Chr7:129145284-129161348 (-)
CAST/EiJ MGP_CASTEiJ_G0032048
 protein coding gene Chr7:122908369-122924092 (-)
CBA/J MGP_CBAJ_G0032692
 protein coding gene Chr7:141129267-141146941 (-)
DBA/2J MGP_DBA2J_G0032844
 protein coding gene Chr7:125909436-125924602 (-)
FVB/NJ MGP_FVBNJ_G0032797
 protein coding gene Chr7:125760435-125776663 (-)
LP/J MGP_LPJ_G0032938
 protein coding gene Chr7:132896326-132911285 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032829
 protein coding gene Chr7:142284658-142300652 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033534
 protein coding gene Chr7:130186947-130205566 (-)
PWK/PhJ MGP_PWKPhJ_G0031755
 protein coding gene Chr7:118907130-118922422 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031601
 protein coding gene Chr7:117030741-117046105 (-)
WSB/EiJ MGP_WSBEiJ_G0032160
 protein coding gene Chr7:131168355-131183411 (-)



Homology
more
  • Human Ortholog
    QPRT, quinolinate phosphoribosyltransferase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QPRT, quinolinate phosphoribosyltransferase
  • Synonyms
    HEL-S-90n, QPRTase
  • Links
    NCBI Gene ID: 23475
    neXtProt AC: NX_Q15274
    UniProt: Q15274

  • Chr Location
    16p11.2; chr16:29663279-29698699 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mitochondrial morphology and physiology in peritoneal macrophages and increased proinflammatory cytokines under basal and LPS-stimulated conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    97
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67375 NCBI Gene Model | MGI Sequence Detail 14260 C57BL/6J ±  kb
transcript NM_133686 RefSeq | MGI Sequence Detail 1211 FVB/N  
polypeptide Q91X91 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013567 nicotinate-nucleotide pyrophosphorylase [carboxylating]
    (term hierarchy)
  • EC
    2.4.2.19
  • InterPro Domains
    IPR013785 Aldolase-type TIM barrel
    IPR004393 Nicotinate-nucleotide pyrophosphorylase
    IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD
    IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal
    IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
    IPR022412 Quinolinate phosphoribosyl transferase, N-terminal
    IPR037128 Quinolinate phosphoribosyl transferase, N-terminal domain superfamily
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142018
References
more
  • Summaries
    All 74
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 6
    Phenotypes 42
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:343179 Chung T, et al., Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern. Aging Cell. 2023 Jul;22(7):e13849
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory