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Qprt Gene Detail
Summary
  • Symbol
    Qprt
  • Name
    quinolinate phosphoribosyltransferase
  • Synonyms
    2410027J01Rik, nicotinate-nucleotide pyrophosphorylase, QPRTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914625
    NCBI Gene: 67375
Location & Maps
more
  • Sequence Map
    Chr7:127107114-127122226 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15113 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.33 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    QPRT, quinolinate phosphoribosyltransferase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    QPRT, quinolinate phosphoribosyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-90n, QPRTase
  • Links
    NCBI Gene ID: 23475
    neXtProt AC: NX_Q15274

  • Chr Location
    16p11.2; chr16:29669840-29697994 (+)  GRCh38.p2

Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    11
  • Gene trapped
    5
  • Targeted
    6
  • Genomic Mutations
    3 involving Qprt
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029412 VEGA Gene Model | MGI Sequence Detail 15113 C57BL/6J ±  kb
transcript OTTMUST00000072893 VEGA | MGI Sequence Detail 2050 Not Applicable  
polypeptide OTTMUSP00000037627 VEGA | MGI Sequence Detail 299 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    128 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013567 nicotinate-nucleotide pyrophosphorylase [carboxylating]
  • EC
  • InterPro Domains
    IPR013785 Aldolase-type TIM barrel
    IPR004393 Nicotinate-nucleotide pyrophosphorylase
    IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD
    IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
    IPR022412 Quinolinate phosphoribosyl transferase, N-terminal
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 5
Other
Accession IDs
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MGI:2142018
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Diseases 6
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory