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Cul4a Gene Detail
Summary
  • Symbol
    Cul4a
  • Name
    cullin 4A
  • Synonyms
    2810470J21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914487
    NCBI Gene: 99375
Location & Maps
more
  • Sequence Map
    Chr8:13105621-13147940 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42320 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CUL4A, cullin 4A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CUL4A, cullin 4A
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 8451
    neXtProt AC: NX_Q13619

  • Chr Location
    13q34; chr13:113208193-113265078 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    2
  • Targeted
    8
  • Genomic Mutations
    1 involving Cul4a
  • Incidental Mutations
Mice homozygous for one knock-out allele exhibit reduced female fertility, male infertility, impaired spermatogenesis, and impaired DNA repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030982 VEGA Gene Model | MGI Sequence Detail 42320 C57BL/6J ±  kb
transcript OTTMUST00000076734 VEGA | MGI Sequence Detail 3728 Not Applicable  
polypeptide OTTMUSP00000040442 VEGA | MGI Sequence Detail 759 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    498 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    cDNA 118

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139358
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226978 Tateossian H, et al., Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015 Dec 1;8(12):1531-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory