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Cul4a
Gene Detail
 Symbol
Name
ID
Cul4a
cullin 4A
MGI:1914487
Synonyms 2810470J21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:13105621-13147940 bp, + strand
From VEGA annotation of GRCm38

  42320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: cullin
Gene Tree: Cul4a

Human
homologs
Human Homolog CUL4A, cullin 4A
NCBI Gene ID 8451
neXtProt AC  NX_Q13619
Human Chr (Location)  13q34; chr13:113208193-113265078 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit reduced female fertility, male infertility, impaired spermatogenesis, and impaired DNA repair.
 
Interactions
Cul4a interacts with 292 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component Cul4A-RING E3 ubiquitin ligase complex, Cul4-RING E3 ubiquitin ligase complex, ...
Function protein binding, ubiquitin protein ligase binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) cDNA(118)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030982 (Evidence)
Ensembl Gene ModelENSMUSG00000031446 (Evidence)
Entrez Gene99375 (Evidence)
UniGene212861
DoTSDT.101735496, DT.531965, DT.91404598, DT.97337778, DT.97352851
NIA Mouse Gene IndexU009100
Consensus CDS ProjectCCDS52485.1
International Mouse Knockout Project StatusCul4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030982 VEGA Gene Model | MGI Sequence Detail 42320 C57BL/6J ±  kb
transcript OTTMUST00000076734 VEGA | MGI Sequence Detail 3728 Not Applicable 
polypeptide OTTMUSP00000040442 VEGA | MGI Sequence Detail 759 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(8) UniProt(9)
Polymorphisms SNPs within 2kb(498 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR016159 Cullin repeat-like-containing domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006049 cullin-4A
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(48)
Other
accession IDs
MGI:2139358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory