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Cul4a
Gene Detail
Symbol

Name
ID
Cul4a
cullin 4A
MGI:1914487
Synonyms
2810470J21Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:13105621-13147940 bp, + strand
From VEGA annotation of GRCm38

  42320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CUL4A
Protein SuperFamily: cullin
Gene Tree: Cul4a

Human
homologs
CUL4A, cullin 4A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8451
neXtProt AC: NX_Q13619

Human Chr (Location): 13q34; chr13:113208193-113265078 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Genomic Mutations involving Cul4a (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit reduced female fertility, male infertility, impaired spermatogenesis, and impaired DNA repair.
 
Interactions
Cul4a interacts with 291 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
cDNA source data(118)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cul4a ; ZFIN cul4a    NEW 
Molecular
reagents
All nucleic(118) cDNA(118)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030982 (Evidence)
Ensembl Gene Model ENSMUSG00000031446 (Evidence)
Entrez Gene 99375 (Evidence)
UniGene 212861
DoTS DT.101735496, DT.531965, DT.91404598, DT.97352851, DT.97337778
NIA Mouse Gene Index U009100
Consensus CDS Project CCDS52485.1
International Mouse Phenotyping Consortium Status Cul4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030982 VEGA Gene Model | MGI Sequence Detail 42320 C57BL/6J ±  kb
transcript OTTMUST00000076734 VEGA | MGI Sequence Detail 3728 Not Applicable 
polypeptide OTTMUSP00000040442 VEGA | MGI Sequence Detail 759 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(498 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR016159 Cullin repeat-like-containing domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006049 cullin-4A
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210976 Yang YL, et al., Lung tumourigenesis in a conditional Cul4A transgenic mouse model. J Pathol. 2014 Jun;233(2):113-23
All references(49)
Other
accession IDs
MGI:2139358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory