Hmg20a MGI Mouse Gene Detail - MGI:1914117

Symbol

Hmg20a
Name

high mobility group 20A
Synonyms

1200004E06Rik, 5730490E10Rik, Hmgxb1, iBRAF

Feature Type

protein coding gene
IDs

MGI:1914117
NCBI Gene: 66867
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:56325893-56404220 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.13 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

1730 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914117	protein coding gene	Chr9:56325891-56404220 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034850	protein coding gene	Chr9:55560482-55639359 (+)
A/J	MGP_AJ_G0034831	protein coding gene	Chr9:53762641-53841588 (+)
AKR/J	MGP_AKRJ_G0034760	protein coding gene	Chr9:55013390-55094234 (+)
BALB/cJ	MGP_BALBcJ_G0034823	protein coding gene	Chr9:53551235-53627324 (+)
C3H/HeJ	MGP_C3HHeJ_G0034533	protein coding gene	Chr9:55474173-55553565 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035342	protein coding gene	Chr9:57132121-57218307 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032253	protein coding gene	Chr9:53114340-53188233 (+)
CAST/EiJ	MGP_CASTEiJ_G0033854	protein coding gene	Chr9:55522340-55642437 (+)
CBA/J	MGP_CBAJ_G0034504	protein coding gene	Chr9:59090367-59175368 (+)
DBA/2J	MGP_DBA2J_G0034663	protein coding gene	Chr9:53656063-53733735 (+)
FVB/NJ	MGP_FVBNJ_G0034605	protein coding gene	Chr9:52854429-52935513 (+)
LP/J	MGP_LPJ_G0034746	protein coding gene	Chr9:55845094-55925367 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034648	protein coding gene	Chr9:60613644-60698600 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035364	protein coding gene	Chr9:55012421-55094242 (+)
PWK/PhJ	MGP_PWKPhJ_G0033559	protein coding gene	Chr9:53666509-53839912 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033393	protein coding gene	Chr9:55294284-55418372 (+)
WSB/EiJ	MGP_WSBEiJ_G0033967	protein coding gene	Chr9:54947584-55027712 (+)

Human Ortholog

HMG20A, high mobility group 20A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMG20A, high mobility group 20A
Synonyms

HMGX1, HMGXB1
Links

HGNC:5001

NCBI Gene ID: 10363

UniProt: Q9NP66
Chr Location

15q24.3; chr15:77420412-77520050 (+) GRCh38

MGI Vertebrate Homology

Hmg20a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HMG20A
Gene Tree

Hmg20a

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Gene trapped

14
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

919
Tissues

88
cDNA Data

19
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hmg20a

ZFIN hmg20a

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All Sequences

58
RefSeq

4
UniProt

3
CCDS

CCDS23208.1

Ensembl

ENSMUSG00000032329 (Evidence)
NCBI Gene

66867

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032329	Ensembl Gene Model \| MGI Sequence Detail	78328	C57BL/6J	± kb
transcript	ENSMUST00000217518	Ensembl \| MGI Sequence Detail	2468	Not Applicable
polypeptide	ENSMUSP00000149359	Ensembl \| MGI Sequence Detail	379	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008626 high mobility group protein 20A

(term hierarchy)
InterPro Domains

IPR051965 Chromatin Regulation and Neuronal Gene Expression

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 6

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MGI:1922963

Summaries

All 47

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 9
Earliest

J:69281 Sumoy L, et al., HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Cytogenet Cell Genet. 2000;88(1-2):62-7
Latest

J:365225 Li C, et al., Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. PLoS Pathog. 2024 May;20(5):e1011783

TSS for Hmg20a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85252	Chr9:56325671-56325683 (+)	-216 bp
Tssr85253	Chr9:56325699-56325709 (+)	-189 bp
Tssr85254	Chr9:56325908-56325965 (+)	44 bp
Tssr85255	Chr9:56325981-56325993 (+)	94 bp
Tssr85256	Chr9:56326089-56326131 (+)	217 bp
Tssr85257	Chr9:56326151-56326158 (+)	262 bp
Tssr85258	Chr9:56326769-56326773 (+)	878 bp
Tssr85259	Chr9:56331700-56331703 (+)	5,809 bp
Tssr85262	Chr9:56384533-56384551 (+)	58,649 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24