Foxp1
Gene Detail

Symbol Name ID

Foxp1 forkhead box P1 MGI:1914004

Synonyms

3110052D19Rik, 4932443N09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

45.74 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:98925338-99522721 bp, - strand From VEGA annotation of GRCm38   597384 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxp1

Human homologs

Human Homolog		FOXP1, forkhead box P1
NCBI Gene ID		27086
neXtProt AC		NX_Q9H334
Human Synonyms		12CC4, hFKH1B, QRF1
Human Chr (Location)		3p14.1; chr3:71003865-71633140 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXP1

Alleles and phenotypes

All alleles(45) : Targeted(6) Gene trapped(39)
 

Homozygous null mice display embryonic lethality with abnormal outflow tract septation, ventricular septal defects, abnormal cardiac valve morphology, decreased and irregular heart rate, thin ventricular compact zone, and edema.

 

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	cardiac muscle cell differentiation, cardiovascular system development, ...
Component	cytoplasm, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (220)    Tissues (103)    Images (46)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	18
RNA in situ	160
Northern blot	16
RT-PCR	26

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(34) Primer pair(4)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000022717 (Evidence)
Ensembl Gene Model	ENSMUSG00000030067 (Evidence)
Entrez Gene	108655 (Evidence)
DFCI	TC1579313, TC1591595, TC1594757, TC1601074, TC1601119, TC1605708, TC1633872, TC1672630
DoTS	DT.101136026, DT.101278977, DT.110495581, DT.110495677, DT.110495680, DT.529676, DT.55109298, DT.55180076, DT.87058772, DT.91282198, DT.91329545, DT.91406772, DT.94184461, DT.94195992
NIA Mouse Gene Index	U027680
Consensus CDS Project	CCDS39578.1, CCDS57441.1, CCDS57442.1
International Mouse Knockout Project Status	Foxp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022717	VEGA Gene Model | MGI Sequence Detail	597384	C57BL/6J
transcript	OTTMUST00000111111	VEGA | MGI Sequence Detail	2121	Not Applicable
polypeptide	OTTMUSP00000062107	VEGA | MGI Sequence Detail	706	Not Applicable

All sequences(197) RefSeq(6) UniProt(21)

Polymorphisms

SNPs(1017 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
InterPro	IPR015880	Zinc finger, C2H2-like
Protein Ontology	PR:000007643	forkhead box protein P1

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:191367 Lee Y, et al., Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci. 2012 Jun;15(6):819-26
All references(115)

Other accession IDs

MGI:1889841, MGI:1920481, MGI:2141684