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Foxp1 Gene Detail
Summary
  • Symbol
    Foxp1
  • Name
    forkhead box P1
  • Synonyms
    3110052D19Rik, 4932443N09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914004
    NCBI Gene: 108655
  • Gene Overview
    MyGene.info: FOXP1
Location & Maps
more
  • Sequence Map
    Chr6:98925338-99522721 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      597384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 45.74 cM, cytoband E1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FOXP1, forkhead box P1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOXP1, forkhead box P1
    Orthology source: HGNC
  • Synonyms
    12CC4, hFKH1B, HSPC215, MFH, QRF1
  • Links
    NCBI Gene ID: 27086
    neXtProt AC: NX_Q9H334

  • Chr Location
    3p13; chr3:70954714-71583989 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FOXP1 associations

Human Disease Mouse Models
       Mental Retardation with Language Impairment and with or without Autistic Features   OMIM: 613670
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Gene trapped
    39
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Foxp1
  • Incidental Mutations
Homozygous null mice display embryonic lethality with abnormal outflow tract septation, ventricular septal defects, abnormal cardiac valve morphology, decreased and irregular heart rate, thin ventricular compact zone, and edema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022717 VEGA Gene Model | MGI Sequence Detail 597384 C57BL/6J ±  kb
transcript OTTMUST00000054485 VEGA | MGI Sequence Detail 2121 Not Applicable  
polypeptide OTTMUSP00000026014 VEGA | MGI Sequence Detail 706 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2427 from dbSNP Build 142
Protein
Information
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  • UniProt
    22 Sequences
  • Protein Ontology
    PR:000007643 forkhead box protein P1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR030456 Fork head domain conserved site 2
    IPR032354 FOXP, coiled-coil domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 54
    cDNA 44
    Primer pair 9
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1889841, MGI:1920481, MGI:2141684
References
more
  • Summaries
    All 154
    Developmental Gene Expression 103
    Gene Ontology 15
    Phenotypes 34
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:234990 Li S, et al., Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development. Dev Biol. 2016 Aug 15;416(2):338-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory