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Foxp1 Gene Detail
Summary
  • Symbol
    Foxp1
  • Name
    forkhead box P1
  • Synonyms
    3110052D19Rik, 4932443N09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914004
    NCBI Gene: 108655
  • Gene Overview
    MyGene.info: FOXP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:98925338-99522721 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      597384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 45.74 cM, cytoband E1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FOXP1, forkhead box P1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOXP1, forkhead box P1
    Orthology source: HGNC
  • Synonyms
    12CC4, hFKH1B, HSPC215, MFH, QRF1
  • Links
    NCBI Gene ID: 27086
    neXtProt AC: NX_Q9H334
    UniProt: Q9H334

  • Chr Location
    3p13; chr3:70954714-71583989 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with abnormal outflow tract septation, ventricular septal defects, abnormal cardiac valve morphology, decreased and irregular heart rate, thin ventricular compact zone, and edema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022717 VEGA Gene Model | MGI Sequence Detail 597384 C57BL/6J ±  kb
    transcript OTTMUST00000054485 VEGA | MGI Sequence Detail 2121 Not Applicable  
    polypeptide OTTMUSP00000026014 VEGA | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2427 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      22 Sequences
    • InterPro Domains
      IPR001766 Fork head domain
      IPR030456 Fork head domain conserved site 2
      IPR032354 FOXP, coiled-coil domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
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    • All nucleic 55
      cDNA 45
      Primer pair 9
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1889841, MGI:1920481, MGI:2141684
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 133
      Gene Ontology 17
      Phenotypes 46
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:262482 Dubos A, et al., A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations. Hum Mol Genet. 2018 Jun 15;27(12):2138-2153

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory