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Foxp1 Gene Detail
Summary
  • Symbol
    Foxp1
  • Name
    forkhead box P1
  • Synonyms
    3110052D19Rik, 4932443N09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914004
    NCBI Gene: 108655
  • Gene Overview
    MyGene.info: FOXP1
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:98925338-99522721 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 45.74 cM, cytoband E1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914004
protein coding gene Chr6:98925338-99522820 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031080
protein coding gene Chr6:100843606-101471460 (-)
A/J MGP_AJ_G0031049
protein coding gene Chr6:97002405-97606891 (-)
AKR/J MGP_AKRJ_G0030980
protein coding gene Chr6:99657972-100278810 (-)
BALB/cJ MGP_BALBcJ_G0031060
protein coding gene Chr6:96973725-97578385 (-)
C3H/HeJ MGP_C3HHeJ_G0030648
protein coding gene Chr6:84130046-84749314 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031519
protein coding gene Chr6:103381243-104027634 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028683
protein coding gene Chr6:94840524-95440434 (-)
CAST/EiJ MGP_CASTEiJ_G0030167
protein coding gene Chr6:99885048-100510473 (-)
CBA/J MGP_CBAJ_G0030746
protein coding gene Chr6:107327636-108004192 (-)
DBA/2J MGP_DBA2J_G0030899
protein coding gene Chr6:96148496-96747502 (-)
FVB/NJ MGP_FVBNJ_G0030853
protein coding gene Chr6:95314200-95914732 (-)
LP/J MGP_LPJ_G0030979
protein coding gene Chr6:100886595-101514112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030887
protein coding gene Chr6:111196906-111829000 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031546
protein coding gene Chr6:99572145-100193200 (-)
PWK/PhJ MGP_PWKPhJ_G0029883
protein coding gene Chr6:95139150-95751997 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029711
protein coding gene Chr6:98468857-99088926 (-)
WSB/EiJ MGP_WSBEiJ_G0030251
protein coding gene Chr6:100064780-100692106 (-)



Homology
more
  • Human Ortholog
    FOXP1, forkhead box P1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOXP1, forkhead box P1
    Orthology source: HGNC
  • Synonyms
    12CC4, hFKH1B, HSPC215, MFH, QRF1
  • Links
    NCBI Gene ID: 27086
    neXtProt AC: NX_Q9H334
    UniProt: Q9H334

  • Chr Location
    3p13; chr3:70954714-71583989 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with abnormal outflow tract septation, ventricular septal defects, abnormal cardiac valve morphology, decreased and irregular heart rate, thin ventricular compact zone, and edema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030067 Ensembl Gene Model | MGI Sequence Detail 597384 C57BL/6J ±  kb
    transcript ENSMUST00000113328 Ensembl | MGI Sequence Detail 2121 Not Applicable  
    polypeptide ENSMUSP00000108954 Ensembl | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      22 Sequences
    • InterPro Domains
      IPR001766 Fork head domain
      IPR030456 Fork head domain conserved site 2
      IPR032354 FOXP, coiled-coil domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
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    • All nucleic 55
      cDNA 45
      Primer pair 9
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1889841, MGI:1920481, MGI:2141684
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 135
      Gene Ontology 17
      Phenotypes 46
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:265044 Parras A, et al., Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature. 2018 Aug;560(7719):441-446

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory