Automated description from the Alliance of Genome Resources (Release 8.3.0)
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator binding activity. Involved in T follicular helper cell differentiation; nervous system development; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within with a positive effect on regulation of androgen receptor signaling pathway. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of transcription by RNA polymerase II; and striated muscle tissue development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and spinal cord. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; carcinoma (multiple); congenital heart disease; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1).
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