About   Help   FAQ
Grina
Gene Detail
Symbol

Name
ID
Grina
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
MGI:1913418
Synonyms
1110025J15Rik, Tmbim3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
35.59 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:76246807-76249904 bp, + strand
From Ensembl annotation of GRCm38

  3098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: GRINA
Protein SuperFamily: glutamate binding protein 1, vertebrate type
Gene Tree: Grina

Human
homologs
GRINA, glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2907
neXtProt AC: NX_Q7Z429

Human Synonyms: HNRGW, LFG1, NMDARA1, TMBIM3

Human Chr (Location): 8q24.3; chr8:143990058-143993419 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Grina (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit no significant alterations in behavior, histopathology or clinical chemistry.
 
Phenotype Images(2)
Interactions
Grina interacts with 87 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (15)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
cDNA source data(179)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grina ; ZFIN grinab    NEW 
Molecular
reagents
All nucleic(179) cDNA(179)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000022564 (Evidence)
Entrez Gene 66168 (Evidence)
UniGene 41665
DFCI TC1572798, TC1755689
DoTS DT.534644, DT.94352947, DT.99863978
NIA Mouse Gene Index U016359
Consensus CDS Project CCDS27563.1
International Mouse Phenotyping Consortium Status Grina
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022564 Ensembl Gene Model | MGI Sequence Detail 3098 C57BL/6J ±  kb
transcript ENSMUST00000023225 Ensembl | MGI Sequence Detail 1693 Not Applicable 
polypeptide ENSMUSP00000023225 Ensembl | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006214 Bax inhibitor 1-related
Protein Ontology PR:000008252 glutamate [NMDA] receptor-associated protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203180 Rojas-Rivera D, et al., TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012 Jun;19(6):1013-26
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory