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Grina
Gene Detail
 Symbol
Name
ID
Grina
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
MGI:1913418
Synonyms 1110025J15Rik, Tmbim3
Feature Type protein coding gene
Genetic Map
Chromosome 15
35.59 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:76246807-76249904 bp, + strand
From NCBI annotation of GRCm38

  3098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: glutamate binding protein 1, vertebrate type
Gene Tree: Grina

Human
homologs
Human Homolog GRINA, glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
NCBI Gene ID 2907
neXtProt AC  NX_Q7Z429
Human Synonyms  HNRGW, LFG1, NMDARA1, TMBIM3
Human Chr (Location)  8q24.3; chr8:143990058-143993428 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Grina (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit no significant alterations in behavior, histopathology or clinical chemistry.
 
Interactions
Grina interacts with 87 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process endoplasmic reticulum calcium ion homeostasis, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Component endoplasmic reticulum, Golgi apparatus, ...
Function ion channel binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (15)    Images (1)
Theiler Stages: 23, 24, 26
Assay TypeResults
RNA in situ 18
cDNA source data(179)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(179) cDNA(179)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022564 (Evidence)
Entrez Gene66168 (Evidence)
UniGene41665
DFCITC1572798, TC1755689
DoTSDT.534644, DT.94352947, DT.99863978
NIA Mouse Gene IndexU016359
Consensus CDS ProjectCCDS27563.1
International Mouse Knockout Project StatusGrina
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66168 NCBI Gene Model | MGI Sequence Detail 3098 C57BL/6J ±  kb
transcript NM_023168 RefSeq | MGI Sequence Detail 1693 C57BL/6 
polypeptide Q9ESF4 UniProt | EBI | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006214 Bax inhibitor 1-related
Protein Ontology PR:000008252 glutamate [NMDA] receptor-associated protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203180 Rojas-Rivera D, et al., TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012 Jun;19(6):1013-26
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory