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Lpin1
Gene Detail
Symbol

Name
ID
Lpin1
lipin 1
MGI:1891340
Synonyms
Lipin1, mKIAA0188
Feature Type
protein coding gene
Genetic Map
Chromosome 12
7.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:16535669-16589770 bp, - strand
From Ensembl annotation of GRCm38

  54102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lpin1

Human
homologs
Human Homolog LPIN1, lipin 1
NCBI Gene ID 23175
neXtProt AC  NX_Q14693
Human Synonyms  PAP1
Human Chr (Location)  2p25.1; chr2:11677545-11827409 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LPIN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(7) Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
ENU-induced mutants show transient hindlimb paralysis, demyelination and myelin sheath defects. Spontaneous mutants show neonatal fatty liver and hypertriglyceridemia, runting, male sterility, peripheral neuropathy, and altered hair growth, myelination, adipogenesis and lipid and glucose metabolism.
 
Phenotype Images(4)
Interactions
Lpin1 interacts with 315 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin cytoskeleton reorganization, cellular response to insulin stimulus, ...
Component cytoplasm, endoplasmic reticulum, ...
Function histone deacetylase binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (23)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
cDNA source data(113)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(113) cDNA(113)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020593 (Evidence)
Entrez Gene14245 (Evidence)
UniGene153625
DFCITC1689015, TC1631272, TC1574621, TC1588299, TC1700824
DoTSDT.91335337, DT.535572, DT.94303533, DT.97400562
NIA Mouse Gene IndexU033829
EC3.1.3.4
Consensus CDS ProjectCCDS25822.1, CCDS25823.1
International Mouse Knockout Project StatusLpin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020593 Ensembl Gene Model | MGI Sequence Detail 54102 C57BL/6J ±  kb
transcript ENSMUST00000067124 Ensembl | MGI Sequence Detail 5581 Not Applicable 
polypeptide ENSMUSP00000070583 Ensembl | MGI Sequence Detail 924 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(34) UniProt(11)
Polymorphisms
SNPs within 2kb(774 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023214 HAD-like domain
InterPro IPR007651 Lipin, N-terminal
InterPro IPR013209 LNS2, Lipin/Ned1/Smp2
Protein Ontology PR:000009894 phosphatidate phosphatase LPIN1
References
(Earliest) J:64452 Sweet HO, et al., fld - fatty liver dystrophy. Mouse News Lett. 1988;81:69
(Latest) J:203485 Creutz CE, et al., Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy. Biochemistry. 2013 Jul 30;52(30):5092-102
All references(83)
Other
accession IDs
MGD-MRK-9822, MGI:1354179, MGI:95552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory