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Lpin1 Gene Detail
Summary
  • Symbol
    Lpin1
  • Name
    lipin 1
  • Synonyms
    Lipin1, mKIAA0188
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891340
    NCBI Gene: 14245
  • Gene Overview
    MyGene.info: LPIN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:16535669-16610966 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75298 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 7.90 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LPIN1, lipin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPIN1, lipin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAP1
  • Links
    NCBI Gene ID: 23175
    neXtProt AC: NX_Q14693
    UniProt: Q14693

  • Chr Location
    2p25.1; chr2:11677544-11827409 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9266
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LPIN1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lpin1 mouse models; 1 with human LPIN1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 4 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    4 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
ENU-induced mutants show transient hindlimb paralysis, demyelination and myelin sheath defects. Spontaneous mutants show neonatal fatty liver and hypertriglyceridemia, runting, male sterility, peripheral neuropathy, and altered hair growth, myelination, adipogenesis and lipid and glucose metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020593 Ensembl Gene Model | MGI Sequence Detail 75298 C57BL/6J ±  kb
    transcript ENSMUST00000111067 Ensembl | MGI Sequence Detail 5433 Not Applicable  
    polypeptide ENSMUSP00000106696 Ensembl | MGI Sequence Detail 924 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1652 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 114
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9822, MGI:1354179, MGI:95552
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 17
      Phenotypes 44
    • Earliest
      J:9801 Langner CA, et al., The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities. J Biol Chem. 1989 May 15;264(14):7994-8003
    • Latest
      J:260850 Kanagaratham C, et al., Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Mamm Genome. 2018 Apr;29(3-4):281-298

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory