Lpin1
Gene Detail

Symbol Name ID

Lpin1 lipin 1 MGI:1891340

Synonyms

Lipin1, mKIAA0188

Feature Type

protein coding gene

Genetic Map

Chromosome 12

7.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr12:16535669-16589770 bp, - strand From NCBI annotation of GRCm38   54102 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lpin1

Human homologs

Human Homolog		LPIN1, lipin 1
NCBI Gene ID		23175
neXtProt AC		NX_Q14693
Human Synonyms		PAP1
Human Chr (Location)		2p25.1; chr2:11677545-11827409 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human LPIN1

Alleles and phenotypes

All alleles(12) : Chemically induced (ENU)(1) Gene trapped(7) Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

ENU-induced mutants show transient hindlimb paralysis, demyelination and myelin sheath defects. Spontaneous mutants show neonatal fatty liver and hypertriglyceridemia, runting, male sterility, peripheral neuropathy, and altered hair growth, myelination, adipogenesis and lipid and glucose metabolism.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	actin cytoskeleton reorganization, cellular response to insulin stimulus, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	histone deacetylase binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (115)    Tissues (23)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	115

cDNA source data(113)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(113) cDNA(113)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000020593 (Evidence)
Entrez Gene	14245 (Evidence)
UniGene	153625
DFCI	TC1574621, TC1588299, TC1631272, TC1689015, TC1700824
DoTS	DT.535572, DT.91335337, DT.94303533, DT.97400562
NIA Mouse Gene Index	U033829
EC	3.1.3.4
Consensus CDS Project	CCDS25822.1, CCDS25823.1
International Mouse Knockout Project Status	Lpin1

Sequences

Length	Strain/Species
genomic	14245	NCBI Gene Model | MGI Sequence Detail	54102	C57BL/6J
transcript	NM_001130412	RefSeq | MGI Sequence Detail	5626	C57BL/6
polypeptide	Q91ZP3	UniProt | EBI | MGI Sequence Detail	924	Not Applicable

All sequences(78) RefSeq(34) UniProt(6)

Polymorphisms

SNPs within 2kb(774 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR023214	HAD-like domain
InterPro	IPR007651	Lipin, N-terminal
InterPro	IPR013209	LNS2, Lipin/Ned1/Smp2
Protein Ontology	PR:000009894	phosphatidate phosphatase LPIN1

Graphical View of Protein Domain Structure

References

(Earliest) J:64452 Sweet HO, et al., fld - fatty liver dystrophy. Mouse News Lett. 1988;81:69
(Latest) J:203485 Creutz CE, et al., Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy. Biochemistry. 2013 Jul 30;52(30):5092-102
All references(83)

Other accession IDs

MGD-MRK-9822, MGI:1354179, MGI:95552