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Lpin1
Gene Detail
 Symbol
Name
ID
Lpin1
lipin 1
MGI:1891340
Synonyms Lipin1, mKIAA0188
Feature Type protein coding gene
Genetic Map
Chromosome 12
7.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:16535669-16589770 bp, - strand
From NCBI annotation of GRCm38

  54102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lpin1

Human
homologs
Human Homolog LPIN1, lipin 1
NCBI Gene ID 23175
neXtProt AC  NX_Q14693
Human Synonyms  PAP1
Human Chr (Location)  2p25.1; chr2:11677545-11827409 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LPIN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(7) Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
ENU-induced mutants show transient hindlimb paralysis, demyelination and myelin sheath defects. Spontaneous mutants show neonatal fatty liver and hypertriglyceridemia, runting, male sterility, peripheral neuropathy, and altered hair growth, myelination, adipogenesis and lipid and glucose metabolism.
 
Phenotype Images(4)
Interactions
Lpin1 interacts with 315 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin cytoskeleton reorganization, cellular response to insulin stimulus, ...
Component cytoplasm, endoplasmic reticulum, ...
Function histone deacetylase binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (23)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 115
cDNA source data(113)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(113) cDNA(113)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020593 (Evidence)
Entrez Gene14245 (Evidence)
UniGene153625
DFCITC1574621, TC1588299, TC1631272, TC1689015, TC1700824
DoTSDT.535572, DT.91335337, DT.94303533, DT.97400562
NIA Mouse Gene IndexU033829
EC3.1.3.4
Consensus CDS ProjectCCDS25822.1, CCDS25823.1
International Mouse Knockout Project StatusLpin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14245 NCBI Gene Model | MGI Sequence Detail 54102 C57BL/6J ±  kb
transcript NM_001130412 RefSeq | MGI Sequence Detail 5626 C57BL/6 
polypeptide Q91ZP3 UniProt | EBI | MGI Sequence Detail 924 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(34) UniProt(6)
Polymorphisms SNPs within 2kb(774 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023214 HAD-like domain
InterPro IPR007651 Lipin, N-terminal
InterPro IPR013209 LNS2, Lipin/Ned1/Smp2
Protein Ontology PR:000009894 phosphatidate phosphatase LPIN1
Graphical View of Protein Domain Structure
References (Earliest) J:64452 Sweet HO, et al., fld - fatty liver dystrophy. Mouse News Lett. 1988;81:69
(Latest) J:203485 Creutz CE, et al., Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy. Biochemistry. 2013 Jul 30;52(30):5092-102
All references(83)
Other
accession IDs
MGD-MRK-9822, MGI:1354179, MGI:95552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory