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Ube3b Gene Detail
Summary
  • Symbol
    Ube3b
  • Name
    ubiquitin protein ligase E3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891295
    NCBI Gene: 117146
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114380607-114421169 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891295
protein coding gene Chr5:114380602-114421169 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029937
protein coding gene Chr5:117116571-117157252 (+)
A/J MGP_AJ_G0029902
protein coding gene Chr5:112518500-112559077 (+)
AKR/J MGP_AKRJ_G0029840
protein coding gene Chr5:116089685-116130337 (+)
BALB/cJ MGP_BALBcJ_G0029913
protein coding gene Chr5:113882821-113923447 (+)
C3H/HeJ MGP_C3HHeJ_G0029633
protein coding gene Chr5:116589244-116632004 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030367
protein coding gene Chr5:121641602-121682203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027595
protein coding gene Chr5:107341605-107382739 (+)
CAST/EiJ MGP_CASTEiJ_G0029041
protein coding gene Chr5:115527084-115568898 (+)
CBA/J MGP_CBAJ_G0029600
protein coding gene Chr5:126283699-126324966 (+)
DBA/2J MGP_DBA2J_G0029750
protein coding gene Chr5:112576493-112617129 (+)
FVB/NJ MGP_FVBNJ_G0029707
protein coding gene Chr5:111383157-111424729 (+)
LP/J MGP_LPJ_G0029839
protein coding gene Chr5:117684980-117727573 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029738
protein coding gene Chr5:130709693-130750252 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030408
protein coding gene Chr5:115558981-115600786 (+)
PWK/PhJ MGP_PWKPhJ_G0028755
protein coding gene Chr5:111216494-111262325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028593
protein coding gene Chr5:113095787-113141303 (+)
WSB/EiJ MGP_WSBEiJ_G0029117
protein coding gene Chr5:116128158-116168718 (+)



Homology
more
  • Human Ortholog
    UBE3B, ubiquitin protein ligase E3B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE3B, ubiquitin protein ligase E3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPIDS, KOS
  • Links
    NCBI Gene ID: 89910
    neXtProt AC: NX_Q7Z3V4
    UniProt: Q7Z3V4

  • Chr Location
    12q24.11; chr12:109477410-109543628 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 13775
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBE3B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit preweaning lethality, reduced fertility, decreased growth, reduced grip strength, impaired hearing, eye inflammation and decreased cholesterol level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029577 Ensembl Gene Model | MGI Sequence Detail 40563 C57BL/6J ±  kb
    transcript ENSMUST00000074002 Ensembl | MGI Sequence Detail 5194 Not Applicable  
    polypeptide ENSMUSP00000073652 Ensembl | MGI Sequence Detail 1070 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 221
      cDNA 219
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140892, MGI:2141051
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:273879 Cheon S, et al., The ubiquitin ligase UBE3B, disrupted in intellectual disability and absent speech, regulates metabolic pathways by targeting BCKDK. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3662-3667

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory