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Lrat
Gene Detail
 Symbol
Name
ID
Lrat
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
MGI:1891259
Synonyms 1300010A18Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
36.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:82892579-82903973 bp, - strand
From VEGA annotation of GRCm38

  11395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

Gene Tree: Lrat

Human
homologs
Human Homolog LRAT, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
NCBI Gene ID 9227
neXtProt AC  NX_O95237
Human Synonyms  LCA14
Human Chr (Location)  4q32.1; chr4:154626961-154753118 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human LRAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
 
Mice homozygous for disruptions in this gene exhibit retinol homeostasis abnormalities and are more susceptible to vitamin A deficiency or display impaired vision associated with abnormal retinol metabolism. Males have testicular hypoplasia/atrophy and reduced mature sperm counts.
 
Human Diseases Modeled Using Mouse Lrat (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Lrat interacts with 395 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process, embryo development, ...
Component cytoplasm, endoplasmic reticulum, ...
Function O-acyltransferase activity, phosphatidylcholine-retinol O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (120)    Tissues (113)    Images (1)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 28
Assay TypeResults
RNA in situ 94
RT-PCR 26
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029021 (Evidence)
Ensembl Gene ModelENSMUSG00000028003 (Evidence)
Entrez Gene79235 (Evidence)
UniGene33921
DFCITC1587814, TC1700855
DoTSDT.40138684
NIA Mouse Gene IndexU024194
EC2.3.1.135
Consensus CDS ProjectCCDS17430.1
International Mouse Knockout Project StatusLrat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029021 VEGA Gene Model | MGI Sequence Detail 11395 C57BL/6J ±  kb
transcript OTTMUST00000072001 VEGA | MGI Sequence Detail 5351 Not Applicable 
polypeptide OTTMUSP00000036977 VEGA | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007053 LRAT-like domain
Protein Ontology PR:000009909 lecithin retinol acyltransferase
References (Earliest) J:66429 Zolfaghari R, et al., Lecithin:retinol acyltransferase from mouse and rat liver. Cdna cloning and liver-specific regulation by dietary vitamin a and retinoic acid. J Lipid Res. 2000 Dec;41(12):2024-34
(Latest) J:210054 Dixon JL, et al., Loss of beta-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys Acta. 2014 Jan;1841(1):34-43
All references(84)
Disease annotation references (3)
Other
accession IDs
MGI:1919009, MGI:2139712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory