Lrat
Gene Detail

Symbol Name ID

Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) MGI:1891259

Synonyms

1300010A18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 3

36.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:82892579-82903973 bp, - strand From VEGA annotation of GRCm38   11395 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lrat

Human homologs

Human Homolog		LRAT, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
NCBI Gene ID		9227
neXtProt AC		NX_O95237
Human Synonyms		LCA14
Human Chr (Location)		4q32.1; chr4:155665163-155674270 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LRAT

Alleles and phenotypes

All alleles(10) : Targeted(9) Gene trapped(1)
 

Mice homozygous for disruptions in this gene exhibit retinol homeostasis abnormalities and are more susceptible to vitamin A deficiency or display impaired vision associated with abnormal retinol metabolism. Males have testicular hypoplasia/atrophy and reduced mature sperm counts.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	1,2-diacyl-sn-glycero-3-phosphocholine metabolic process, embryo development, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	O-acyltransferase activity, phosphatidylcholine-retinol O-acyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (123)    Tissues (113)    Images (1)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	29

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000029021 (Evidence)
Ensembl Gene Model	ENSMUSG00000028003 (Evidence)
Entrez Gene	79235 (Evidence)
UniGene	33921
DFCI	TC1587814, TC1700855
DoTS	DT.40138684
NIA Mouse Gene Index	U024194
EC	2.3.1.135
Consensus CDS Project	CCDS17430.1
International Mouse Knockout Project Status	Lrat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029021	VEGA Gene Model | MGI Sequence Detail	11395	C57BL/6J
transcript	OTTMUST00000072001	VEGA | MGI Sequence Detail	5351	Not Applicable
polypeptide	OTTMUSP00000036977	VEGA | MGI Sequence Detail	231	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007053	LRAT-like domain
Protein Ontology	PR:000009909	lecithin retinol acyltransferase

References

(Earliest) J:66429 Zolfaghari R, et al., Lecithin:retinol acyltransferase from mouse and rat liver. Cdna cloning and liver-specific regulation by dietary vitamin a and retinoic acid. J Lipid Res. 2000 Dec;41(12):2024-34
(Latest) J:194158 Zhang N, et al., Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest. 2013 Jan 2;123(1):121-37
All references(70)

Other accession IDs

MGI:1919009, MGI:2139712