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Lrat Gene Detail
Summary
  • Symbol
    Lrat
  • Name
    lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
  • Synonyms
    1300010A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891259
    NCBI Gene: 79235
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82892582-82903974 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891259
protein coding gene Chr3:82892579-82903974 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027330
protein coding gene Chr3:82712051-82725060 (-)
A/J MGP_AJ_G0027294
protein coding gene Chr3:79985273-79996718 (-)
AKR/J MGP_AKRJ_G0027260
protein coding gene Chr3:81893669-81906869 (-)
BALB/cJ MGP_BALBcJ_G0027303
protein coding gene Chr3:80077775-80089427 (-)
C3H/HeJ MGP_C3HHeJ_G0027047
protein coding gene Chr3:82166435-82178439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027749
protein coding gene Chr3:85831544-85845504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025102
protein coding gene Chr3:75717063-75728841 (-)
CAST/EiJ MGP_CASTEiJ_G0026494
protein coding gene Chr3:82364097-82375536 (-)
CBA/J MGP_CBAJ_G0027022
protein coding gene Chr3:88738657-88749876 (-)
DBA/2J MGP_DBA2J_G0027158
protein coding gene Chr3:79535306-79546699 (-)
FVB/NJ MGP_FVBNJ_G0027126
protein coding gene Chr3:77818121-77829465 (-)
LP/J MGP_LPJ_G0027266
protein coding gene Chr3:83702777-83714170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027145
protein coding gene Chr3:95121849-95133910 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027807
protein coding gene Chr3:81680334-81693085 (-)
PWK/PhJ MGP_PWKPhJ_G0026228
protein coding gene Chr3:79288555-79300031 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026044
protein coding gene Chr3:80883535-80890957 (-)
WSB/EiJ MGP_WSBEiJ_G0026572
protein coding gene Chr3:82021677-82034009 (-)



Homology
more
  • Human Ortholog
    LRAT, lecithin retinol acyltransferase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    LRAT, lecithin retinol acyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LCA14
  • Links
    NCBI Gene ID: 9227
    neXtProt AC: NX_O95237
    UniProt: O95237

  • Chr Location
    4q32.1; chr4:154740841-154753119 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3483
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRAT
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrat mouse models; 2 with human LRAT associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    2 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit retinol homeostasis abnormalities and are more susceptible to vitamin A deficiency or display impaired vision associated with abnormal retinol metabolism. Males have testicular hypoplasia/atrophy and reduced mature sperm counts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 79235 NCBI Gene Model | MGI Sequence Detail 11393 C57BL/6J ±  kb
    transcript NM_023624 RefSeq | MGI Sequence Detail 5349 Not Specified  
    polypeptide Q9JI60 UniProt | EBI | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919009, MGI:2139712
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 9
      Phenotypes 64
    • Earliest
      J:66429 Zolfaghari R, et al., Lecithin:retinol acyltransferase from mouse and rat liver. Cdna cloning and liver-specific regulation by dietary vitamin a and retinoic acid. J Lipid Res. 2000 Dec;41(12):2024-34
    • Latest
      J:235440 Zhang T, et al., Dimerization of visual pigments in vivo. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9093-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory