About   Help   FAQ
Lrat
Gene Detail
Symbol

Name
ID
Lrat
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
MGI:1891259
Synonyms
1300010A18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:82892579-82903973 bp, - strand
From VEGA annotation of GRCm38

  11395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

HCOP human homology predictions: LRAT
Gene Tree: Lrat

Human
homologs
LRAT, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9227
neXtProt AC: NX_O95237

Human Synonyms: LCA14

Human Chr (Location): 4q32.1; chr4:154626961-154753119 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human LRAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
 
Mice homozygous for disruptions in this gene exhibit retinol homeostasis abnormalities and are more susceptible to vitamin A deficiency or display impaired vision associated with abnormal retinol metabolism. Males have testicular hypoplasia/atrophy and reduced mature sperm counts.
 
Human Diseases Modeled in Mice Using Lrat (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Lrat interacts with 394 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (120)    Tissues (113)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 26
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN lrata, lratb    NEW 
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029021 (Evidence)
Ensembl Gene Model ENSMUSG00000028003 (Evidence)
Entrez Gene 79235 (Evidence)
UniGene 33921
DFCI TC1587814, TC1700855
DoTS DT.40138684
NIA Mouse Gene Index U024194
EC 2.3.1.135
PDB 4Q95
Consensus CDS Project CCDS17430.1
International Mouse Phenotyping Consortium Status Lrat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029021 VEGA Gene Model | MGI Sequence Detail 11395 C57BL/6J ±  kb
transcript OTTMUST00000072001 VEGA | MGI Sequence Detail 5351 Not Applicable 
polypeptide OTTMUSP00000036977 VEGA | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007053 LRAT-like domain
Protein Ontology PR:000009909 lecithin retinol acyltransferase
References
(Earliest) J:66429 Zolfaghari R, et al., Lecithin:retinol acyltransferase from mouse and rat liver. Cdna cloning and liver-specific regulation by dietary vitamin a and retinoic acid. J Lipid Res. 2000 Dec;41(12):2024-34
(Latest) J:219366 Zhang T, et al., Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis. Hum Mol Genet. 2015 Mar 15;24(6):1755-63
All references(87)
Disease annotation references (3)
Other
accession IDs
MGI:1919009, MGI:2139712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory