About   Help   FAQ
Lrat Gene Detail
Summary
  • Symbol
    Lrat
  • Name
    lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
  • Synonyms
    1300010A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891259
    NCBI Gene: 79235
Location & Maps
more
  • Sequence Map
    Chr3:82892579-82903973 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11395 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRAT, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
  • Vertebrate Orthologs
    12
  • Human Ortholog
    LRAT, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LCA14
  • Links
    NCBI Gene ID: 9227
    neXtProt AC: NX_O95237

  • Chr Location
    4q32.1; chr4:154626961-154753119 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3483
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: LRAT
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrat mouse models; 2 with human LRAT associations

Human Disease Mouse Models
       Leber Congenital Amaurosis 14; LCA14   OMIM: 613341 View 1 model
       Retinitis Pigmentosa; RP   OMIM: 268000
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Lrat
Mice homozygous for disruptions in this gene exhibit retinol homeostasis abnormalities and are more susceptible to vitamin A deficiency or display impaired vision associated with abnormal retinol metabolism. Males have testicular hypoplasia/atrophy and reduced mature sperm counts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029021 VEGA Gene Model | MGI Sequence Detail 11395 C57BL/6J ±  kb
transcript OTTMUST00000072001 VEGA | MGI Sequence Detail 5351 Not Applicable  
polypeptide OTTMUSP00000036977 VEGA | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    97 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 8
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919009, MGI:2139712
References
more
  • Summaries
    All 86
    Developmental Gene Expression 7
    Diseases 3
    Gene Ontology 5
    Phenotypes 57
  • Earliest
    J:66429 Zolfaghari R, et al., Lecithin:retinol acyltransferase from mouse and rat liver. Cdna cloning and liver-specific regulation by dietary vitamin a and retinoic acid. J Lipid Res. 2000 Dec;41(12):2024-34
  • Latest
    J:225502 Liu H, et al., Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28;290(35):21568-79

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory