|
Symbol Name ID |
Lrat
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) MGI:1891259 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal retinal vascular morphology |
Attenuation of retinal blood vessels |
Keratoconus |
Posterior subcapsular cataract |
Optic atrophy |
Optic disc pallor |
Abnormality of retinal pigmentation |
Bone spicule pigmentation of the retina |
Retinal degeneration |
Retinal dystrophy |
Rod-cone dystrophy |
Abnormal electroretinogram |
Decreased light- and dark-adapted electroretinogram amplitude |
Undetectable electroretinogram |
Nystagmus |
Ophthalmoplegia |
Nyctalopia |
Progressive night blindness |
Photophobia |
Photopsia |
Visual impairment |
Reduced visual acuity |
Blindness |
Congenital blindness |
Peripheral visual field loss |
Glaucoma |
| Disease(s) Associated with LRAT | ||||||||||||||||||||||||||
| Leber congenital amaurosis 14 | ||||||||||||||||||||||||||
| retinitis pigmentosa |
| Mouse Phenotypes | vision/eye phenotype |
abnormal retina photoreceptor morphology |
short photoreceptor outer segment |
abnormal retina cone cell outer segment morphology |
retina cone cell degeneration |
retina rod cell degeneration |
retina photoreceptor degeneration |
thin retina outer nuclear layer |
abnormal eye electrophysiology |
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| Availability | Mouse Genotype | |||||||||
| Lrattm1.1Bok/Lrattm1.1Bok | ||||||||||
| Lrattm1Kpal/Lrattm1Kpal | ||||||||||
| Lrattm1Kpal/Lrat+ | * | |||||||||
| Lrattm1Bok/Lrattm1Bok Tg(Tyrp1-cre)1Ipc/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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