Tbx19
Gene Detail

Symbol Name ID

Tbx19 T-box 19 MGI:1891158

Synonyms

D1Ertd754e, Tpit

Feature Type

protein coding gene

Genetic Map

Chromosome 1

72.47 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:165137855-165160773 bp, - strand From VEGA annotation of GRCm38   22919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Tbx19 ± 2 cM)

Protein SuperFamily: mouse gene T protein
Gene Tree: Tbx19

Human ortholog

TBX19 T-box 19 NCBI Gene ID 9095
Human Synonyms: dJ747L4.1, TBS19, TPIT
Human Chr1:168250278-168283664 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human TBX19 (1)

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.

 
Human Diseases Modeled Using Mouse Tbx19 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell fate commitment, pituitary gland development, ...
Component	nucleus
Function	DNA binding, enhancer sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (115)    Tissues (84)    Images (20)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	98
RT-PCR	17

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(17) Primer pair(3) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034848 (Evidence)
Ensembl Gene Model	ENSMUSG00000026572 (Evidence)
Entrez Gene	83993 (Evidence)
UniGene	190649
DFCI	TC1585075
DoTS	DT.483359
NIA Mouse Gene Index	U021988
Consensus CDS Project	CCDS15439.1
International Mouse Knockout Project Status	Tbx19

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034848	VEGA Gene Model | MGI Sequence Detail	22919	C57BL/6J
transcript	OTTMUST00000088588	VEGA | MGI Sequence Detail	2660	Not Applicable
polypeptide	OTTMUSP00000048294	VEGA | MGI Sequence Detail	446	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(163 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR002070	Transcription factor, Brachyury
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000016147	T-box transcription factor TBX19

References

(Earliest) J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
(Latest) J:188254 Budry L, et al., The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
All references(54)

Other accession IDs

MGI:1289162, MGI:2138434