About   Help   FAQ
Tbx19 Gene Detail
Summary
  • Symbol
    Tbx19
  • Name
    T-box 19
  • Synonyms
    D1Ertd754e, Tpit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891158
    NCBI Gene: 83993
  • Gene Overview
    MyGene.info: TBX19
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:165137855-165160773 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22919 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.47 cM, cytoband H2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TBX19, T-box 19
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TBX19, T-box 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ747L4.1, TBS19, TPIT
  • Links
    NCBI Gene ID: 9095
    neXtProt AC: NX_O60806
    UniProt: O60806

  • Chr Location
    1q24.2; chr1:168281040-168314426 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tbx19 mouse models; 1 with human TBX19 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034848 VEGA Gene Model | MGI Sequence Detail 22919 C57BL/6J ±  kb
    transcript OTTMUST00000088588 VEGA | MGI Sequence Detail 2660 Not Applicable  
    polypeptide OTTMUSP00000048294 VEGA | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      310 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 3
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1289162, MGI:2138434
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
    • Latest
      J:245758 Carreno G, et al., Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory