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Tbx19
Gene Detail
Symbol

Name
ID
Tbx19
T-box 19
MGI:1891158
Synonyms
D1Ertd754e, Tpit
Feature Type
protein coding gene
Genetic Map
Chromosome 1
72.47 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:165137855-165160773 bp, - strand
From VEGA annotation of GRCm38

  22919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3779  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TBX19
Protein SuperFamily: mouse gene T protein
Gene Tree: Tbx19

Human
homologs
TBX19, T-box 19
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9095
neXtProt AC: NX_O60806

Human Synonyms: dJ747L4.1, TBS19, TPIT

Human Chr (Location): 1q24.2; chr1:168281040-168314426 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TBX19

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.
 
Human Diseases Modeled in Mice Using Tbx19 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tbx19 interacts with 132 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell fate commitment, pituitary gland development, ...
Component nucleus
Function DNA binding, enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (112)    Tissues (80)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 98
RT-PCR 10
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(17) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034848 (Evidence)
Ensembl Gene Model ENSMUSG00000026572 (Evidence)
Entrez Gene 83993 (Evidence)
UniGene 190649
DFCI TC1585075
DoTS DT.483359
NIA Mouse Gene Index U021988
Consensus CDS Project CCDS15439.1
International Mouse Phenotyping Consortium Status Tbx19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034848 VEGA Gene Model | MGI Sequence Detail 22919 C57BL/6J ±  kb
transcript OTTMUST00000088588 VEGA | MGI Sequence Detail 2660 Not Applicable 
polypeptide OTTMUSP00000048294 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(312 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016147 T-box transcription factor TBX19
References
(Earliest) J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(58)
Disease annotation references (1)
Other
accession IDs
MGI:1289162, MGI:2138434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory