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Tbx19 Gene Detail
Summary
  • Symbol
    Tbx19
  • Name
    T-box 19
  • Synonyms
    D1Ertd754e, Tpit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891158
    NCBI Gene: 83993
  • Gene Overview
    MyGene.info: TBX19
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165137855-165160773 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.47 cM, cytoband H2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    310 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891158
protein coding gene Chr1:165137834-165160773 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016688
protein coding gene Chr1:170605825-170631842 (-)
A/J MGP_AJ_G0016669
protein coding gene Chr1:163650660-163676280 (-)
AKR/J MGP_AKRJ_G0016635
protein coding gene Chr1:168603421-168628256 (-)
BALB/cJ MGP_BALBcJ_G0016630
protein coding gene Chr1:164142053-164164695 (-)
C3H/HeJ MGP_C3HHeJ_G0016454
protein coding gene Chr1:168823134-168848912 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017091
protein coding gene Chr1:176332947-176359118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014800
protein coding gene Chr1:155570351-155590738 (-)
CAST/EiJ MGP_CASTEiJ_G0016034
protein coding gene Chr1:168451736-168476130 (-)
CBA/J MGP_CBAJ_G0016429
protein coding gene Chr1:182605385-182632769 (-)
DBA/2J MGP_DBA2J_G0016535
protein coding gene Chr1:162542165-162565030 (-)
FVB/NJ MGP_FVBNJ_G0016533
protein coding gene Chr1:160995215-161020056 (-)
LP/J MGP_LPJ_G0016606
protein coding gene Chr1:171684363-171708405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016558
protein coding gene Chr1:190116472-190142186 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017127
protein coding gene Chr1:168454539-168478501 (-)
PWK/PhJ MGP_PWKPhJ_G0015820
protein coding gene Chr1:161742453-161766250 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015607
protein coding gene Chr1:167318507-167342167 (-)
WSB/EiJ MGP_WSBEiJ_G0016096
protein coding gene Chr1:168614700-168637472 (-)



Homology
more
  • Human Ortholog
    TBX19, T-box 19
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TBX19, T-box 19
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ747L4.1, TBS19, TPIT
  • Links
    NCBI Gene ID: 9095
    neXtProt AC: NX_O60806
    UniProt: O60806

  • Chr Location
    1q24.2; chr1:168281040-168314426 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tbx19 mouse models; 1 with human TBX19 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026572 Ensembl Gene Model | MGI Sequence Detail 22919 C57BL/6J ±  kb
    transcript ENSMUST00000027859 Ensembl | MGI Sequence Detail 2660 Not Applicable  
    polypeptide ENSMUSP00000027859 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 3
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1289162, MGI:2138434
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 35
      Diseases 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
    • Latest
      J:266340 Mayran A, et al., Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate. Nat Genet. 2018 Feb;50(2):259-269

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory