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Il21r
Gene Detail
 Symbol
Name
ID
Il21r
interleukin 21 receptor
MGI:1890475
Synonyms NILR
Feature Type protein coding gene
Genetic Map
Chromosome 7
68.98 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:125603429-125633570 bp, + strand
From NCBI annotation of GRCm38

  30142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Il21r

Human
homologs
Human Homolog IL21R, interleukin 21 receptor
NCBI Gene ID 50615
neXtProt AC  NX_Q9HBE5
Human Synonyms  CD360, NILR
Human Chr (Location)  16p11; chr16:27402162-27452042 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human IL21R
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.
 
Phenotype Images(1)
Interactions
Il21r interacts with 95 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cytokine-mediated signaling pathway
Component integral component of membrane, membrane
Function cytokine receptor activity, transmembrane signaling receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (3)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 37
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000030745 (Evidence)
Entrez Gene60504 (Evidence)
UniGene155643
DFCITC1584637, TC1628878
DoTSDT.101727248, DT.91338456, DT.91338457, DT.91583278, DT.99611098
NIA Mouse Gene IndexU008759
Consensus CDS ProjectCCDS21823.1
International Mouse Knockout Project StatusIl21r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 60504 NCBI Gene Model | MGI Sequence Detail 30142 C57BL/6J ±  kb
transcript NM_021887 RefSeq | MGI Sequence Detail 2607 C57BL/6 
polypeptide Q9JHX3 UniProt | EBI | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000008998 interleukin-21 receptor
Graphical View of Protein Domain Structure
References (Earliest) J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
(Latest) J:209939 Nakayamada S, et al., Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J Immunol. 2014 Mar 1;192(5):2156-66
All references(110)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory