About   Help   FAQ
Il21r
Gene Detail
Symbol

Name
ID
Il21r
interleukin 21 receptor
MGI:1890475
Synonyms
NILR
Feature Type
protein coding gene
Genetic Map
Chromosome 7
68.98 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:125603429-125633570 bp, + strand
From Ensembl annotation of GRCm38

  30142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IL21R
Gene Tree: Il21r

Human
homologs
IL21R, interleukin 21 receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 50615
neXtProt AC: NX_Q9HBE5

Human Synonyms: CD360, NILR

Human Chr (Location): 16p11; chr16:27402162-27452042 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IL21R

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.
 
Phenotype Images(1)
Interactions
Il21r interacts with 95 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (3)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase il21r ; ZFIN il21r.1, il21r.2    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030745 (Evidence)
Entrez Gene 60504 (Evidence)
UniGene 155643
DFCI TC1584637, TC1628878
DoTS DT.101727248, DT.91338456, DT.91338457, DT.91583278, DT.99611098
NIA Mouse Gene Index U008759
Consensus CDS Project CCDS21823.1
International Mouse Phenotyping Consortium Status Il21r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030745 Ensembl Gene Model | MGI Sequence Detail 30142 C57BL/6J ±  kb
transcript ENSMUST00000033000 Ensembl | MGI Sequence Detail 2607 Not Applicable 
polypeptide ENSMUSP00000033000 Ensembl | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000008998 interleukin-21 receptor
References
(Earliest) J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
(Latest) J:221656 Hashimoto-Kataoka T, et al., Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2677-86
All references(111)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory