Il21r Gene Detail

Summary

• Symbol
  Il21r
• Name
  interleukin 21 receptor
• Synonyms
  NILR

• Feature Type
  protein coding gene
• IDs
  MGI:1890475
  NCBI Gene: 60504
• Gene Overview
  MyGene.info: IL21R
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr7:125603429-125633570 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    30142 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 68.98 cM, cytoband F4
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  IL21R, interleukin 21 receptor

• Vertebrate Orthologs
  10

• Human Ortholog
  IL21R, interleukin 21 receptor
  Orthology source: HomoloGene, HGNC
• Synonyms
  CD360, IMD56, NILR
• Links
  HGNC:6006

  NCBI Gene ID: 50615

  neXtProt AC: NX_Q9HBE5

  UniProt: Q9HBE5

  
  
• Chr Location
  16p12.1; chr16:27402162-27452045 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 11040
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: IL21R
• Gene Tree
  Il21r
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  45 phenotypes from 4 alleles in 7 genetic backgrounds
  10 phenotypes from multigenic genotypes
  1 images
  98 phenotype references
  

• All Mutations and Alleles
  6
• Targeted
  6
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  17 strains or lines available

Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  4

• External Resources
  FuncBase

Expression

• Assay Results
  37
• Tissues
  3
• cDNA Data
  8
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN il21r.1, il21r.2

Interactions

• Il21r interacts with 95 markers (Mir22, Mir24-1, Mir24-2, ...) View All

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  6
• UniProt
  6
• CCDS
  CCDS21823.1
• UniGene
  155643

• VEGA
  OTTMUSG00000058203 (Evidence)
• Ensembl
  ENSMUSG00000030745 (Evidence)
• NCBI Gene
  60504

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000058203	VEGA Gene Model | MGI Sequence Detail	30142	C57BL/6J
transcript	OTTMUST00000142919	VEGA | MGI Sequence Detail	2499	Not Applicable
polypeptide	OTTMUSP00000074529	VEGA | MGI Sequence Detail	529	Not Applicable

Polymorphisms

• SNPs within 2kb
  328 from dbSNP Build 142

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000008998 interleukin-21 receptor
  (term hierarchy)
• InterPro Domains
  IPR003961 Fibronectin type III
  IPR036116 Fibronectin type III superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003531 Short hematopoietin receptor, family 1, conserved site

Molecular
Reagents

• All nucleic 8

  cDNA 8

  
  

  Microarray probesets 2

References

• Summaries
  All 127

  Developmental Gene Expression 1

  Gene Ontology 4

  Phenotypes 98
• Earliest
  J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
• Latest
  J:251074 Cheekatla SS, et al., IL-21 Receptor Signaling Is Essential for Optimal CD4(+) T Cell Function and Control of Mycobacterium tuberculosis Infection in Mice. J Immunol. 2017 Oct 15;199(8):2815-2822