About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Il21r Gene Detail
Summary
  • Symbol
    Il21r
  • Name
    interleukin 21 receptor
  • Synonyms
    NILR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890475
    NCBI Gene: 60504
  • Gene Overview
    MyGene.info: IL21R
Location & Maps
more
  • Sequence Map
    Chr7:125603429-125633570 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      30142 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 68.98 cM, cytoband F4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL21R, interleukin 21 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL21R, interleukin 21 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD360, NILR
  • Links
    NCBI Gene ID: 50615
    neXtProt AC: NX_Q9HBE5

  • Chr Location
    16p11; chr16:27402162-27452042 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 11040
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: IL21R
  • Gene Tree
    Il21r
Human Diseases
more
  • Diseases
    2 with human IL21R associations

Human Disease Mouse Models
       IgE Responsiveness, Atopic; IGER   OMIM: 147050
Il21r Immunodeficiency   OMIM: 615207
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 4 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    37
  • Tissues
    3
  • cDNA Data
    8
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058203 VEGA Gene Model | MGI Sequence Detail 30142 C57BL/6J ±  kb
transcript OTTMUST00000142919 VEGA | MGI Sequence Detail 2499 Not Applicable  
polypeptide OTTMUSP00000074529 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    328 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008998 interleukin-21 receptor
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR003531 Short hematopoietin receptor, family 1, conserved site
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 115
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 90
  • Earliest
    J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
  • Latest
    J:231161 Mittal D, et al., Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8+ T Cells. Cancer Res. 2016 Jan 15;76(2):264-74
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory