Il21r MGI Mouse Gene Detail - MGI:1890475

Symbol

Il21r
Name

interleukin 21 receptor
Synonyms

NILR

Feature Type

protein coding gene
IDs

MGI:1890475
NCBI Gene: 60504
Gene Overview

MyGene.info: IL21R
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:125202601-125232742 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 68.98 cM, cytoband F4
Mapping Data

1 experiment

SNPs within 2kb

306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890475	protein coding gene	Chr7:125202424-125232742 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032969	protein coding gene	Chr7:129815670-129847681 (+)
A/J	MGP_AJ_G0032952	protein coding gene	Chr7:126415918-126445573 (+)
AKR/J	MGP_AKRJ_G0032884	protein coding gene	Chr7:129611072-129641851 (+)
BALB/cJ	MGP_BALBcJ_G0032957	protein coding gene	Chr7:126069517-126102005 (+)
C3H/HeJ	MGP_C3HHeJ_G0032667	protein coding gene	Chr7:129527902-129557779 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033463	protein coding gene	Chr7:134898686-134930070 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030435	protein coding gene	Chr7:127618271-127646629 (+)
CAST/EiJ	MGP_CASTEiJ_G0031995	protein coding gene	Chr7:121322280-121355314 (+)
CBA/J	MGP_CBAJ_G0032640	protein coding gene	Chr7:139418483-139459278 (+)
DBA/2J	MGP_DBA2J_G0032792	protein coding gene	Chr7:124393307-124423218 (+)
FVB/NJ	MGP_FVBNJ_G0032745	protein coding gene	Chr7:124228784-124257889 (+)
LP/J	MGP_LPJ_G0032886	protein coding gene	Chr7:131288588-131317721 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032777	protein coding gene	Chr7:140661798-140695198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033483	protein coding gene	Chr7:128611459-128642156 (+)
PWK/PhJ	MGP_PWKPhJ_G0031703	protein coding gene	Chr7:117372617-117402563 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031550	protein coding gene	Chr7:115435421-115464256 (+)
WSB/EiJ	MGP_WSBEiJ_G0032108	protein coding gene	Chr7:129579131-129608509 (+)

Human Ortholog

IL21R, interleukin 21 receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL21R, interleukin 21 receptor
Synonyms

CD360, IMD56, NILR
Links

HGNC:6006

NCBI Gene ID: 50615

neXtProt AC: NX_Q9HBE5

UniProt: Q9HBE5
Chr Location

16p12.1; chr16:27402162-27452045 (+) GRCh38.p7

Alliance of Genome Resources

Il21r stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IL21R
Gene Tree

Il21r

Diseases

1 with human IL21R associations

				Human Disease	Mouse Models
				immunodeficiency 56 IDs immunodeficiency 56 DOID:0111982 OMIM:615207 ORDO:357329 UMLS_CUI:C3554687

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

49 phenotypes from 5 alleles in 8 genetic backgrounds
10 phenotypes from multigenic genotypes
3 images
116 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

668
Tissues

3
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN il21r.1, il21r.2

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Il21r interacts with 95 markers (Mir22, Mir24-1, Mir24-2, ...) View All

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All Sequences

59
RefSeq

10
UniProt

6
CCDS

CCDS21823.1

Ensembl

ENSMUSG00000030745 (Evidence)
NCBI Gene

60504

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030745	Ensembl Gene Model \| MGI Sequence Detail	30142	C57BL/6J	± kb
transcript	ENSMUST00000033000	Ensembl \| MGI Sequence Detail	2499	Not Applicable
polypeptide	ENSMUSP00000033000	Ensembl \| MGI Sequence Detail	529	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008998 interleukin-21 receptor

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR003531 Short hematopoietin receptor, family 1, conserved site

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All nucleic 9

cDNA 9

Microarray probesets 2

Summaries

All 145

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 116
Earliest

J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
Latest

J:289403 Yang Z, et al., IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells. J Exp Med. 2020 May 4;217(5)

TSS for Il21r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68984	Chr7:125202592-125202609 (+)	0 bp
Tssr68985	Chr7:125202615-125202646 (+)	30 bp
Tssr68986	Chr7:125202653-125202668 (+)	60 bp
Tssr68987	Chr7:125202759-125202772 (+)	165 bp
Tssr68988	Chr7:125202788-125202797 (+)	192 bp
Tssr68989	Chr7:125202812-125202823 (+)	217 bp
Tssr68990	Chr7:125206798-125206841 (+)	4,219 bp
Tssr68991	Chr7:125229785-125229799 (+)	27,191 bp
Tssr68992	Chr7:125229818-125229832 (+)	27,224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/14/2021 MGI 6.17