Il21r MGI Mouse Gene Detail - MGI:1890475

Il21r Gene Detail

Symbol

Il21r
Name

interleukin 21 receptor
Synonyms

NILR

Feature Type

protein coding gene
IDs

MGI:1890475
NCBI Gene: 60504
Gene Overview

MyGene.info: IL21R

Sequence Map

Chr7:125603429-125633570 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

30142 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 68.98 cM, cytoband F4
Mapping Data

1 experiment

Human Ortholog

IL21R, interleukin 21 receptor

Vertebrate Orthologs

10

Human Ortholog

IL21R, interleukin 21 receptor
Orthology source: HomoloGene, HGNC
Synonyms

CD360, NILR
Links

HGNC:6006

NCBI Gene ID: 50615

neXtProt AC: NX_Q9HBE5

UniProt: Q9HBE5
Chr Location

16p12.1; chr16:27402162-27452045 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11040
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: IL21R
Gene Tree

Il21r

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Phenotype Summary

45 phenotypes from 4 alleles in 7 genetic backgrounds
9 phenotypes from multigenic genotypes
1 images
91 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.

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All GO Annotations

6
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

37
Tissues

3
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il21r

ZFIN il21r.1, il21r.2

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Il21r interacts with 95 markers (Mir22, Mir24-1, Mir24-2, ...) View All

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All Sequences

45
RefSeq

6
UniProt

6
CCDS

CCDS21823.1
UniGene

155643

			Length	Strain/Species	Flank
genomic	OTTMUSG00000058203	VEGA Gene Model \| MGI Sequence Detail	30142	C57BL/6J	± kb
transcript	OTTMUST00000142919	VEGA \| MGI Sequence Detail	2499	Not Applicable
polypeptide	OTTMUSP00000074529	VEGA \| MGI Sequence Detail	529	Not Applicable

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SNPs within 2kb

328 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000008998 interleukin-21 receptor

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR013783 Immunoglobulin-like fold

IPR003531 Short hematopoietin receptor, family 1, conserved site

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All nucleic 8

cDNA 8

Microarray probesets 2

Summaries

All 117

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 91
Earliest

J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
Latest

J:239957 Bunting MD, et al., GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity. Blood. 2017 Feb 02;129(5):630-642

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/13/2017 MGI 6.10