Il21r
Gene Detail

Symbol Name ID

Il21r interleukin 21 receptor MGI:1890475

Synonyms

NILR

Feature Type

protein coding gene

Genetic Map

Chromosome 7

68.98 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:125603429-125633570 bp, + strand From NCBI annotation of GRCm38   30142 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Il21r

Human homologs

Human Homolog		IL21R, interleukin 21 receptor
NCBI Gene ID		50615
neXtProt AC		NX_Q9HBE5
Human Synonyms		CD360, NILR
Human Chr (Location)		16p11; chr16:27402162-27452042 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human IL21R

Mutations, alleles, and phenotypes

All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.

 
Phenotype Images(1)

Interactions

Il21r interacts with 95 markers (Mir22, Mir24-1, Mir24-2, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cytokine-mediated signaling pathway
Component	integral component of membrane, membrane
Function	cytokine receptor activity, transmembrane signaling receptor activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (37)    Tissues (3)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	37

cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000030745 (Evidence)
Entrez Gene	60504 (Evidence)
UniGene	155643
DFCI	TC1584637, TC1628878
DoTS	DT.101727248, DT.91338456, DT.91338457, DT.91583278, DT.99611098
NIA Mouse Gene Index	U008759
Consensus CDS Project	CCDS21823.1
International Mouse Knockout Project Status	Il21r

Sequences

Length	Strain/Species
genomic	60504	NCBI Gene Model | MGI Sequence Detail	30142	C57BL/6J
transcript	NM_021887	RefSeq | MGI Sequence Detail	2607	C57BL/6
polypeptide	Q9JHX3	UniProt | EBI | MGI Sequence Detail	529	Not Applicable

All sequences(39) RefSeq(6) UniProt(5)

Polymorphisms

SNPs within 2kb(325 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003531	Short hematopoietin receptor, family 1, conserved site
Protein Ontology	PR:000008998	interleukin-21 receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
(Latest) J:209939 Nakayamada S, et al., Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J Immunol. 2014 Mar 1;192(5):2156-66
All references(110)