About   Help   FAQ
Il21r Gene Detail
Summary
  • Symbol
    Il21r
  • Name
    interleukin 21 receptor
  • Synonyms
    NILR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890475
    NCBI Gene: 60504
  • Gene Overview
    MyGene.info: IL21R
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:125603429-125633570 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      30142 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 68.98 cM, cytoband F4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL21R, interleukin 21 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL21R, interleukin 21 receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD360, IMD56, NILR
  • Links
    NCBI Gene ID: 50615
    neXtProt AC: NX_Q9HBE5
    UniProt: Q9HBE5

  • Chr Location
    16p12.1; chr16:27402162-27452045 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 11040
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IL21R
  • Gene Tree
    Il21r
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 4 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    37
  • Tissues
    3
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058203 VEGA Gene Model | MGI Sequence Detail 30142 C57BL/6J ±  kb
    transcript OTTMUST00000142919 VEGA | MGI Sequence Detail 2499 Not Applicable  
    polypeptide OTTMUSP00000074529 VEGA | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      328 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 99
    • Earliest
      J:65263 Ozaki K, et al., Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11439-44
    • Latest
      J:262863 Zhang Y, et al., Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. J Exp Med. 2018 Apr 2;215(4):1227-1243
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    09/18/2018
    MGI 6.12     		The Jackson Laboratory