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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il21r
interleukin 21 receptor
MGI:1890475
49 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il21rem1(IMPC)Mbp/Il21rem1(IMPC)Mbp
C57BL/6N-Il21rem1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal kidney morphology J:211773
enlarged kidney J:211773
increased exploration in new environment J:211773
Il21rtm1Day/Il21rtm1Day
C57BL/6-Il21rtm1Day 		abnormal susceptibility to infection J:111712
abnormal T-helper 2 physiology J:111712
decreased IgG1 level J:111712
decreased IgG2b level J:111712
decreased interleukin-4 secretion J:111712
decreased interleukin-13 secretion J:111712
decreased interleukin-21 secretion J:111712
Il21rtm1Day/Il21rtm1Day
involves: BALB/c * C57BL/6 		abnormal CD4-positive T cell differentiation J:123352, J:136955
abnormal dendritic cell physiology J:144708
abnormal Langerhans cell physiology J:144708
abnormal memory T cell physiology J:76043
abnormal NK cell physiology J:76043
abnormal plasmacytoid dendritic cell physiology J:144708
abnormal T cell activation J:76043
abnormal T cell physiology J:76043
abnormal thymocyte activation J:76043
decreased CD4-positive, alpha-beta T cell number J:123352
decreased cytotoxic T cell cytolysis J:76043
decreased IgE level J:144708
decreased IgG1 level J:76043, J:144708
decreased IgG2a level J:144708
decreased IgG2b level J:76043
decreased interferon-gamma secretion J:144708
decreased interleukin-4 secretion J:144708
decreased interleukin-13 secretion J:144708
decreased interleukin-17 secretion J:123352
decreased susceptibility to type IV hypersensitivity reaction J:144708
impaired natural killer cell mediated cytotoxicity J:76043
increased IgE level J:76043
increased interferon-gamma secretion J:76043, J:123352
Il21rtm1Kopf/Il21rtm1Kopf
B6.129-Il21rtm1Kopf 		abnormal immune system morphology J:137508
abnormal immune system physiology J:137508
abnormal immunoglobulin level J:137508
abnormal leukocyte physiology J:137508
abnormal lymphocyte physiology J:137508
abnormal T-helper 1 physiology J:137508
abnormal T-helper 2 physiology J:137508
decreased basophil cell number J:137508
decreased eosinophil cell number J:137508
decreased granulocyte number J:137508
decreased IgA level J:137508
decreased IgG1 level J:137508
granulomatous inflammation J:137508
impaired eosinophil recruitment J:137508
increased IgE level J:137508
increased susceptibility to experimental autoimmune encephalomyelitis J:137377
Il21rtm1Kopf/Il21rtm1Kopf
involves: 129/Sv * BALB/c 		abnormal immunoglobulin level J:137508
abnormal lymphocyte physiology J:137508
decreased IgA level J:137508
decreased IgG1 level J:137508
normal immune system phenotype J:137377
impaired eosinophil recruitment J:137508
increased IgE level J:137508
Il21rtm1Lex/Il21rtm1Lex
involves: 129S5/SvEvBrd * C57BL/6J 		increased circulating triglyceride level J:103485
Il21rtm1Wjl/Il21rtm1Wjl
involves: 129 * C57BL/6 		abnormal CD8-positive, alpha-beta T cell physiology J:95221
abnormal immunoglobulin level J:80474
decreased cytotoxic T cell cytolysis J:95221
decreased IgG1 level J:80474
decreased IgG2a level J:80474
decreased IgG2b level J:80474
decreased IgG3 level J:80474
decreased interleukin-17 secretion J:124293
increased IgE level J:80474
Il21rtm1Wjl/Il21rtm1Wjl
NOD.Cg-Il21rtm1Wjl 		abnormal CD4-positive T cell differentiation J:139075
decreased interleukin-17 secretion J:139075
decreased susceptibility to autoimmune diabetes J:139075
decreased T cell proliferation J:139075
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory