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Igf2bp1 Gene Detail
Summary
  • Symbol
    Igf2bp1
  • Name
    insulin-like growth factor 2 mRNA binding protein 1
  • Synonyms
    Crdbp, CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP1, IMP-1, Zbp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890357
    NCBI Gene: 140486
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95847989-95896766 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890357
protein coding gene Chr11:95847989-95896770 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018993
protein coding gene Chr11:98224168-98275238 (-)
A/J MGP_AJ_G0018961
protein coding gene Chr11:94233145-94283392 (-)
AKR/J MGP_AKRJ_G0018931
protein coding gene Chr11:97135494-97187432 (-)
BALB/cJ MGP_BALBcJ_G0018934
protein coding gene Chr11:94719230-94768885 (-)
C3H/HeJ MGP_C3HHeJ_G0018748
protein coding gene Chr11:97274010-97327310 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019386
protein coding gene Chr11:101287957-101346277 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017016
protein coding gene Chr11:91722325-91770898 (-)
CAST/EiJ MGP_CASTEiJ_G0018302
protein coding gene Chr11:98088358-98140605 (-)
CBA/J MGP_CBAJ_G0018719
protein coding gene Chr11:105434089-105491731 (-)
DBA/2J MGP_DBA2J_G0018827
protein coding gene Chr11:93802539-93851377 (-)
FVB/NJ MGP_FVBNJ_G0018816
protein coding gene Chr11:93282137-93330975 (-)
LP/J MGP_LPJ_G0018897
protein coding gene Chr11:98774677-98828187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018843
protein coding gene Chr11:105442687-105496674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019426
protein coding gene Chr11:97430265-97479778 (-)
PWK/PhJ MGP_PWKPhJ_G0018073
protein coding gene Chr11:94747684-94797885 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017862
protein coding gene Chr11:97129503-97190967 (-)
WSB/EiJ MGP_WSBEiJ_G0018351
protein coding gene Chr11:97333359-97384820 (-)



Homology
more
  • Human Ortholog
    IGF2BP1, insulin like growth factor 2 mRNA binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2BP1, insulin like growth factor 2 mRNA binding protein 1
  • Synonyms
    CRDBP, CRD-BP, IMP1, IMP-1, VICKZ1, ZBP1
  • Links
    NCBI Gene ID: 10642
    neXtProt AC: NX_Q9NZI8
    UniProt: Q9NZI8

  • Chr Location
    17q21.32; chr17:48996558-49056145 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this locus results in increased neonatal lethality, growth retardation, and impaired intestinal development. Males exhibit increased anxiety-like response and decreased exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013415 Ensembl Gene Model | MGI Sequence Detail 48778 C57BL/6J ±  kb
    transcript ENSMUST00000013559 Ensembl | MGI Sequence Detail 8378 Not Applicable  
    polypeptide ENSMUSP00000013559 Ensembl | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 13
      cDNA 28
      Primer pair 5
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1330862, MGI:1343090, MGI:1343099, MGI:1343130, MGI:2138604, MGI:2144349, MGI:2442575
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 23
      Gene Ontology 6
      Phenotypes 33
    • Earliest
      J:1689 Forejt J, et al., Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Cell. 1992 Aug 7;70(3):443-50
    • Latest
      J:328997 Nunez L, et al., Tagged actin mRNA dysregulation in IGF2BP1 -/- mice. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2208465119

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory