Igf2bp1
Gene Detail

Symbol Name ID

Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 MGI:1890357

Synonyms

Crdbp, CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Zbp1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:95957163-96005940 bp, - strand From VEGA annotation of GRCm38   48778 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Igf2bp1 ± 2 cM)

Gene Tree: Igf2bp1

Human ortholog

IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 NCBI Gene ID 10642
Human Synonyms: CRDBP, CRD-BP, IMP1, IMP-1, VICKZ1, ZBP1
Human Chr17:47074774-47133507 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(158) : Targeted(2) Gene trapped(156)
 

Homozygous mutation of this locus results in increased neonatal lethality, growth retardation, and impaired intestinal development. Males exhibit increased anxiety-like response and decreased exploratory behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	CRD-mediated mRNA stabilization, negative regulation of translation, ...
Component	CRD-mediated mRNA stability complex, cytoplasm, ...
Function	mRNA 3'-UTR binding, mRNA 5'-UTR binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (109)    Tissues (78)    Images (35)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	98
Northern blot	5
Western blot	2
RT-PCR	4

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(13) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000001937 (Evidence)
Ensembl Gene Model	ENSMUSG00000013415 (Evidence)
Entrez Gene	140486 (Evidence)
DFCI	TC1577290, TC1581785, TC1585903, TC1613798, TC1672356, TC1736257
DoTS	DT.101340032, DT.40171821, DT.525530, DT.528321, DT.94286789, DT.97335837
NIA Mouse Gene Index	U033312
Consensus CDS Project	CCDS25286.1
International Mouse Knockout Project Status	Igf2bp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001937	VEGA Gene Model | MGI Sequence Detail	48778	C57BL/6J
transcript	OTTMUST00000003877	VEGA | MGI Sequence Detail	8378	Not Applicable
polypeptide	OTTMUSP00000001867	VEGA | MGI Sequence Detail	577	Not Applicable

All sequences(59) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004087	K Homology domain
InterPro	IPR004088	K Homology domain, type 1
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000008943	insulin-like growth factor 2 mRNA-binding protein 1

References

(Earliest) J:39732 Leeds P, et al., Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro. Oncogene. 1997 Mar 20;14(11):1279-86
(Latest) J:192172 Nalavadi VC, et al., Regulation of zipcode binding protein 1 transport dynamics in axons by myosin Va. J Neurosci. 2012 Oct 24;32(43):15133-41
All references(58)

Other accession IDs

MGI:1330862, MGI:1343090, MGI:1343099, MGI:1343130, MGI:2138604, MGI:2144349, MGI:2442575