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Igf2bp1 Gene Detail
Summary
  • Symbol
    Igf2bp1
  • Name
    insulin-like growth factor 2 mRNA binding protein 1
  • Synonyms
    Crdbp, CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Zbp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890357
    NCBI Gene: 140486
  • Gene Overview
    MyGene.info: IGF2BP1
Location & Maps
more
  • Sequence Map
    Chr11:95957163-96005940 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48778 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.08 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IGF2BP1, insulin like growth factor 2 mRNA binding protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IGF2BP1, insulin like growth factor 2 mRNA binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRDBP, CRD-BP, IMP1, IMP-1, VICKZ1, ZBP1
  • Links
    NCBI Gene ID: 10642
    neXtProt AC: NX_Q9NZI8

  • Chr Location
    17q21.32; chr17:48997412-49056145 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    161
  • Gene trapped
    156
  • Targeted
    5
  • Genomic Mutations
    2 involving Igf2bp1
  • Incidental Mutations
Homozygous mutation of this locus results in increased neonatal lethality, growth retardation, and impaired intestinal development. Males exhibit increased anxiety-like response and decreased exploratory behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001937 VEGA Gene Model | MGI Sequence Detail 48778 C57BL/6J ±  kb
transcript OTTMUST00000003877 VEGA | MGI Sequence Detail 8378 Not Applicable  
polypeptide OTTMUSP00000001867 VEGA | MGI Sequence Detail 577 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    343 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008943 insulin-like growth factor 2 mRNA-binding protein 1
  • InterPro Domains
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 42
    Genomic 13
    cDNA 25
    Primer pair 3
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1330862, MGI:1343090, MGI:1343099, MGI:1343130, MGI:2138604, MGI:2144349, MGI:2442575
References
more
  • Summaries
    All 62
    Developmental Gene Expression 18
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:39732 Leeds P, et al., Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro. Oncogene. 1997 Mar 20;14(11):1279-86
  • Latest
    J:226649 Hamilton KE, et al., Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res. 2015 Nov;13(11):1478-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory