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Igf2bp1
Gene Detail
Symbol

Name
ID
Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
MGI:1890357
Synonyms
Crdbp, CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Zbp1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:95957163-96005940 bp, - strand
From VEGA annotation of GRCm38

  48778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4772  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Igf2bp1

Human
homologs
Human Homolog IGF2BP1, insulin-like growth factor 2 mRNA binding protein 1
NCBI Gene ID 10642
neXtProt AC  NX_Q9NZI8
Human Synonyms  CRDBP, CRD-BP, IMP1, IMP-1, VICKZ1, ZBP1
Human Chr (Location)  17q21.32; chr17:48997412-49056145 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(160) : Gene trapped(156) Targeted(4)
Genomic Mutations involving Igf2bp1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this locus results in increased neonatal lethality, growth retardation, and impaired intestinal development. Males exhibit increased anxiety-like response and decreased exploratory behavior.
 
Interactions
Igf2bp1 interacts with 527 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process CRD-mediated mRNA stabilization, mRNA transport, ...
Component cell projection, CRD-mediated mRNA stability complex, ...
Function mRNA 3'-UTR binding, mRNA 5'-UTR binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (124)    Tissues (87)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
Northern blot 5
Western blot 2
RT-PCR 18
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(13) cDNA(25) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000001937 (Evidence)
Ensembl Gene ModelENSMUSG00000013415 (Evidence)
Entrez Gene140486 (Evidence)
DFCITC1585903, TC1577290, TC1581785, TC1736257, TC1672356, TC1613798
DoTSDT.528321, DT.525530, DT.40171821, DT.101340032, DT.97335837, DT.94286789
NIA Mouse Gene IndexU033312
Consensus CDS ProjectCCDS25286.1
International Mouse Knockout Project StatusIgf2bp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001937 VEGA Gene Model | MGI Sequence Detail 48778 C57BL/6J ±  kb
transcript OTTMUST00000003877 VEGA | MGI Sequence Detail 8378 Not Applicable 
polypeptide OTTMUSP00000001867 VEGA | MGI Sequence Detail 577 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(344 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000008943 insulin-like growth factor 2 mRNA-binding protein 1
References
(Earliest) J:39732 Leeds P, et al., Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro. Oncogene. 1997 Mar 20;14(11):1279-86
(Latest) J:207231 Nishino J, et al., A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife. 2013;2:e00924
All references(63)
Other
accession IDs
MGI:1330862, MGI:1343090, MGI:1343099, MGI:1343130, MGI:2138604, MGI:2144349, MGI:2442575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory