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Tbx21 Gene Detail
Summary
  • Symbol
    Tbx21
  • Name
    T-box 21
  • Synonyms
    Tbet, T-bet, Tblym, TBT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888984
    NCBI Gene: 57765
  • Gene Overview
    MyGene.info: TBX21
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:97098071-97115331 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17261 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.95 cM, cytoband D
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TBX21, T-box 21
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TBX21, T-box 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    T-bet, TBET, TBLYM, T-PET
  • Links
    NCBI Gene ID: 30009
    neXtProt AC: NX_Q9UL17
    UniProt: Q9UL17

  • Chr Location
    17q21.32; chr17:47733240-47746122 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tbx21 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 7 genetic backgrounds
    35 phenotypes from multigenic genotypes
    1 images
    249 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in the production of NK and NK-T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002233 VEGA Gene Model | MGI Sequence Detail 17261 C57BL/6J ±  kb
    transcript OTTMUST00000004472 VEGA | MGI Sequence Detail 2488 Not Applicable  
    polypeptide OTTMUSP00000002150 VEGA | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      122 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 10
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 358
      Developmental Gene Expression 24
      Diseases 2
      Gene Ontology 15
      Phenotypes 249
    • Earliest
      J:105228 Zhumabekov T, et al., Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods. 1995 Sep 11;185(1):133-40
    • Latest
      J:265084 Mikami Y, et al., NCR(+) ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice. Eur J Immunol. 2018 Jul;48(7):1174-1180

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory