Tbx21
Gene Detail

Symbol Name ID

Tbx21 T-box 21 MGI:1888984

Synonyms

T-bet, Tblym, TBT1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

60.95 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:97098071-97115331 bp, - strand From VEGA annotation of GRCm38   17261 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tbx21

Human homologs

Human Homolog		TBX21, T-box 21
NCBI Gene ID		30009
neXtProt AC		NX_Q9UL17
Human Synonyms		T-bet, TBET, TBLYM, T-PET
Human Chr (Location)		17q21.32; chr17:45810610-45823485 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TBX21

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(1) Chemically induced(1)
 

Mice homozygous for disruptions in this gene display defects in the production of NK and NK-T cells.

 
Human Diseases Modeled Using Mouse Tbx21 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	lymphocyte migration, positive regulation of isotype switching to IgG isotypes, ...
Component	neuronal cell body, nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (48)    Tissues (45)    Images (6)
Theiler Stages: 17, 21, 23, 28

Assay Type	Results
RNA in situ	44
RT-PCR	4

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(2) cDNA(9) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000002233 (Evidence)
Ensembl Gene Model	ENSMUSG00000001444 (Evidence)
Entrez Gene	57765 (Evidence)
UniGene	94519
DFCI	TC1586542
DoTS	DT.40155340
NIA Mouse Gene Index	U033334
Consensus CDS Project	CCDS25315.1
International Mouse Knockout Project Status	Tbx21

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002233	VEGA Gene Model | MGI Sequence Detail	17261	C57BL/6J
transcript	OTTMUST00000004472	VEGA | MGI Sequence Detail	2488	Not Applicable
polypeptide	OTTMUSP00000002150	VEGA | MGI Sequence Detail	530	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000001835	T-box transcription factor TBX21

References

(Earliest) J:61321 Szabo SJ, et al., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000 Mar 17;100(6):655-69
(Latest) J:196056 Fuchs A, et al., Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-gamma-Producing Cells. Immunity. 2013 Apr 18;38(4):769-81
All references(237)