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Tbx21
Gene Detail
 Symbol
Name
ID
Tbx21
T-box 21
MGI:1888984
Synonyms Tbet, T-bet, Tblym, TBT1
Feature Type protein coding gene
Genetic Map
Chromosome 11
60.95 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:97098071-97115331 bp, - strand
From VEGA annotation of GRCm38

  17261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tbx21

Human
homologs
Human Homolog TBX21, T-box 21
NCBI Gene ID 30009
neXtProt AC  NX_Q9UL17
Human Synonyms  T-bet, TBET, TBLYM, T-PET
Human Chr (Location)  17q21.32; chr17:47733244-47746119 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TBX21
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display defects in the production of NK and NK-T cells.
 
Human Diseases Modeled Using Mouse Tbx21 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Tbx21 interacts with 123 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to organic substance, lymphocyte migration, ...
Component neuronal cell body, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (57)    Tissues (50)    Images (14)
Theiler Stages: 17, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 53
RT-PCR 4
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000002233 (Evidence)
Ensembl Gene ModelENSMUSG00000001444 (Evidence)
Entrez Gene57765 (Evidence)
UniGene94519
DFCITC1586542
DoTSDT.40155340
NIA Mouse Gene IndexU033334
Consensus CDS ProjectCCDS25315.1
International Mouse Knockout Project StatusTbx21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002233 VEGA Gene Model | MGI Sequence Detail 17261 C57BL/6J ±  kb
transcript OTTMUST00000004472 VEGA | MGI Sequence Detail 2488 Not Applicable 
polypeptide OTTMUSP00000002150 VEGA | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000001835 T-box transcription factor TBX21
References (Earliest) J:61321 Szabo SJ, et al., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000 Mar 17;100(6):655-69
(Latest) J:211676 Male V, et al., The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med. 2014 Apr 7;211(4):635-42
All references(267)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory