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Tbx21 Gene Detail
Summary
  • Symbol
    Tbx21
  • Name
    T-box 21
  • Synonyms
    Tbet, T-bet, Tblym, TBT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888984
    NCBI Gene: 57765
  • Gene Overview
    MyGene.info: TBX21
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97098071-97115331 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.95 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888984
protein coding gene Chr11:97098007-97115331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019024
protein coding gene Chr11:99480763-99499508 (-)
A/J MGP_AJ_G0018992
protein coding gene Chr11:95408940-95426095 (-)
AKR/J MGP_AKRJ_G0018962
protein coding gene Chr11:98372394-98390846 (-)
BALB/cJ MGP_BALBcJ_G0018965
protein coding gene Chr11:95897136-95914187 (-)
C3H/HeJ MGP_C3HHeJ_G0018779
protein coding gene Chr11:98479474-98497645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019417
protein coding gene Chr11:102563213-102586071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017048
protein coding gene Chr11:92869565-92887168 (-)
CAST/EiJ MGP_CASTEiJ_G0018332
protein coding gene Chr11:99332594-99351512 (-)
CBA/J MGP_CBAJ_G0018750
protein coding gene Chr11:106794478-106813326 (-)
DBA/2J MGP_DBA2J_G0018858
protein coding gene Chr11:94959296-94976669 (-)
FVB/NJ MGP_FVBNJ_G0018847
protein coding gene Chr11:94441541-94458833 (-)
LP/J MGP_LPJ_G0018928
protein coding gene Chr11:100008709-100028127 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018874
protein coding gene Chr11:106693003-106712624 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019457
protein coding gene Chr11:98657345-98677904 (-)
PWK/PhJ MGP_PWKPhJ_G0018104
protein coding gene Chr11:95932497-95950120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017894
protein coding gene Chr11:98375220-98393446 (-)
WSB/EiJ MGP_WSBEiJ_G0018382
protein coding gene Chr11:98568375-98587729 (-)



Homology
more
  • Human Ortholog
    TBX21, T-box 21
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TBX21, T-box 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    T-bet, TBET, TBLYM, T-PET
  • Links
    NCBI Gene ID: 30009
    neXtProt AC: NX_Q9UL17
    UniProt: Q9UL17

  • Chr Location
    17q21.32; chr17:47733240-47746122 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tbx21 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 7 genetic backgrounds
    35 phenotypes from multigenic genotypes
    1 images
    250 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in the production of NK and NK-T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001444 Ensembl Gene Model | MGI Sequence Detail 17261 C57BL/6J ±  kb
    transcript ENSMUST00000001484 Ensembl | MGI Sequence Detail 2488 Not Applicable  
    polypeptide ENSMUSP00000001484 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 10
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 359
      Developmental Gene Expression 25
      Diseases 2
      Gene Ontology 15
      Phenotypes 250
    • Earliest
      J:105228 Zhumabekov T, et al., Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods. 1995 Sep 11;185(1):133-40
    • Latest
      J:266242 Desmaris E, et al., DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 Oct 17;38(42):9105-9121

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory