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Tbx21
Gene Detail
Symbol

Name
ID
Tbx21
T-box 21
MGI:1888984
Synonyms
Tbet, T-bet, Tblym, TBT1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
60.95 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:97098071-97115331 bp, - strand
From VEGA annotation of GRCm38

  17261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TBX21
Gene Tree: Tbx21

Human
homologs
TBX21, T-box 21
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 30009
neXtProt AC: NX_Q9UL17

Human Synonyms: T-bet, TBET, TBLYM, T-PET

Human Chr (Location): 17q21.32; chr17:47733244-47746122 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TBX21

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(5)
Genomic Mutations involving Tbx21 (1)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for disruptions in this gene display defects in the production of NK and NK-T cells.
 
Human Diseases Modeled in Mice Using Tbx21 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Tbx21 interacts with 123 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to organic substance, lymphocyte migration, ...
Component neuronal cell body, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (57)    Tissues (50)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
RT-PCR 4
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tbx21 ; ZFIN tbx21    NEW 
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000002233 (Evidence)
Ensembl Gene Model ENSMUSG00000001444 (Evidence)
Entrez Gene 57765 (Evidence)
UniGene 94519
DFCI TC1586542
DoTS DT.40155340
NIA Mouse Gene Index U033334
Consensus CDS Project CCDS25315.1
International Mouse Phenotyping Consortium Status Tbx21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002233 VEGA Gene Model | MGI Sequence Detail 17261 C57BL/6J ±  kb
transcript OTTMUST00000004472 VEGA | MGI Sequence Detail 2488 Not Applicable 
polypeptide OTTMUSP00000002150 VEGA | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000001835 T-box transcription factor TBX21
References
(Earliest) J:61321 Szabo SJ, et al., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000 Mar 17;100(6):655-69
(Latest) J:220530 Baumann C, et al., T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4056-61
All references(273)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory