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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbx21
T-box 21
MGI:1888984
40 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tbx21duane/Tbx21duane
C57BL/6-Tbx21duane 		abnormal NK cell differentiation J:154069
absent NK T cells J:154069
decreased NK cell number J:154069
increased NK cell number J:154069
Tbx21m1Btlr/Tbx21m1Btlr
C57BL/6J-Tbx21m1Btlr 		increased CD8-positive, alpha-beta T cell number J:267478
increased effector memory CD8-positive, alpha-beta T cell number J:267478
increased IgM level J:267478
Tbx21tm1Glm/Tbx21+
involves: 129S6/SvEvTac * C57BL/6 		abnormal cytokine level J:73833
abnormal interleukin level J:73832
abnormal NK cell physiology J:73833
abnormal respiratory system morphology J:73832
abnormal tumor necrosis factor level J:73832
decreased T helper 1 cell number J:73833
increased airway responsiveness J:73832
Tbx21tm1Glm/Tbx21tm1Glm
B6.129S6-Tbx21tm1Glm 		abnormal CD4-positive T cell differentiation J:143729
Tbx21tm1Glm/Tbx21tm1Glm
C.129S6-Tbx21tm1Glm/J 		abnormal CD4-positive, alpha-beta T cell physiology J:111932
abnormal cytokine secretion J:111932
CNS inflammation J:111932
decreased susceptibility to experimental autoimmune encephalomyelitis J:111932
Tbx21tm1Glm/Tbx21tm1Glm
involves: 129S6/SvEvTac 		abnormal cytokine level J:112600
abnormal leukocyte migration J:163822
decreased CD4-positive, alpha-beta T cell number J:163822
decreased memory T cell number J:163822
increased interleukin-17 secretion J:163822
increased susceptibility to induced colitis J:141481
Tbx21tm1Glm/Tbx21tm1Glm
involves: 129S6/SvEvTac * C57BL/6 		abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:73833
abnormal cytokine level J:73832
abnormal immunoglobulin level J:73833
abnormal interleukin level J:73832
abnormal NK cell physiology J:73833
abnormal respiratory system morphology J:73832
abnormal T-helper 1 cell differentiation J:73833
abnormal tumor necrosis factor level J:73832
decreased interferon-gamma secretion J:73833
decreased T helper 1 cell number J:73833
impaired natural killer cell mediated cytotoxicity J:73833
increased airway responsiveness J:73832
increased natural killer cell mediated cytotoxicity J:73833
increased susceptibility to parasitic infection J:73833
increased T-helper 2 cell number J:73833
respiratory system inflammation J:73832
Tbx21tm1Srnr/Tbx21+
involves: C57BL/6 		absent NK T cells J:112679
decreased NK cell number J:112679
Tbx21tm1Srnr/Tbx21tm1Srnr
involves: C57BL/6 		abnormal T-helper 1 cell morphology J:112679
decreased NK T cell number J:112679
Tbx21tm2Srnr/Tbx21+
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:174315
increased susceptibility to Riboviria infection J:174315
Tbx21tm2Srnr/Tbx21tm2Srnr
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:174315
normal immune system phenotype J:137655
increased interleukin-2 secretion J:174315
increased interleukin-17 secretion J:174315
increased susceptibility to Riboviria infection J:174315
increased tumor necrosis factor secretion J:174315
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory