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Tbx20 Gene Detail
Summary
  • Symbol
    Tbx20
  • Name
    T-box 20
  • Synonyms
    9430010M06Rik, Tbx12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888496
    NCBI Gene: 57246
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:24720812-24774303 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53492 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 10.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TBX20, T-box 20
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TBX20, T-box 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASD4
  • Links
    NCBI Gene ID: 57057
    neXtProt AC: NX_Q9UMR3
    UniProt: Q9UMR3

  • Chr Location
    7p14.2; chr7:35199936-35254100 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32476
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TBX20
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tbx20 mouse models; 1 with human TBX20 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, impaired cardiac looping, a small hourglass shaped heart, and decreased cardiomyocyte proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57246 NCBI Gene Model | MGI Sequence Detail 53492 C57BL/6J ±  kb
    transcript NM_194263 RefSeq | MGI Sequence Detail 6436 C57BL/6  
    polypeptide Q9ES03 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      585 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 22
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1924493, MGI:2143174
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 84
      Diseases 1
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:63825 Meins M, et al., Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene. Genomics. 2000 Aug 1;67(3):317-32
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory