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Tbx20
Gene Detail
Symbol

Name
ID
Tbx20
T-box 20
MGI:1888496
Synonyms
9430010M06Rik, Tbx12
Feature Type
protein coding gene
Genetic Map
Chromosome 9
10.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:24720812-24774303 bp, - strand
From NCBI annotation of GRCm38

  53492 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32476  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TBX20
Gene Tree: Tbx20

Human
homologs
TBX20, T-box 20
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57057
neXtProt AC: NX_Q9UMR3

Human Synonyms: ASD4

Human Chr (Location): 7p14.3; chr7:35202430-35254100 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TBX20

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, impaired cardiac looping, a small hourglass shaped heart, and decreased cardiomyocyte proliferation.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Tbx20 interacts with 415 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process aortic valve development, aortic valve morphogenesis, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (223)    Tissues (128)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 213
RT-PCR 10
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TBX20 ; Xenbase tbx20 ; ZFIN tbx20    NEW 
Molecular
reagents
All nucleic(26) cDNA(22) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000031965 (Evidence)
Entrez Gene 57246 (Evidence)
UniGene 31452
DFCI TC1591721, TC1585943, TC1609149, TC1620327, TC1609830
DoTS DT.101709523, DT.524196, DT.87029137, DT.101161799, DT.94244052
NIA Mouse Gene Index U030623
Consensus CDS Project CCDS22933.1, CCDS52744.1
International Mouse Phenotyping Consortium Status Tbx20
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57246 NCBI Gene Model | MGI Sequence Detail 53492 C57BL/6J ±  kb
transcript NM_194263 RefSeq | MGI Sequence Detail 6436 C57BL/6 
polypeptide Q9ES03 UniProt | EBI | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(585 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016149 T-box transcription factor TBX20
Graphical View of Protein Domain Structure
References
(Earliest) J:63825 Meins M, et al., Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene. Genomics. 2000 Aug 1;67(3):317-32
(Latest) J:213620 Kong P, et al., Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
All references(104)
Other
accession IDs
MGI:1924493, MGI:2143174

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory