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Tbx20 Gene Detail
Summary
  • Symbol
    Tbx20
  • Name
    T-box 20
  • Synonyms
    9430010M06Rik, Tbx12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888496
    NCBI Gene: 57246
Location & Maps
more
  • Sequence Map
    Chr9:24720812-24774303 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53492 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 10.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TBX20, T-box 20
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TBX20, T-box 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASD4
  • Links
    NCBI Gene ID: 57057
    neXtProt AC: NX_Q9UMR3

  • Chr Location
    7p14.2; chr7:35202430-35254100 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32476
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TBX20
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TBX20 associations

Human Disease Mouse Models
       Atrial Septal Defect 4; ASD4   OMIM: 611363
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    1
  • Targeted
    11
  • Incidental Mutations
Homozygous null mice display embryonic lethality, impaired cardiac looping, a small hourglass shaped heart, and decreased cardiomyocyte proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57246 NCBI Gene Model | MGI Sequence Detail 53492 C57BL/6J ±  kb
transcript NM_194263 RefSeq | MGI Sequence Detail 6436 C57BL/6  
polypeptide Q9ES03 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    585 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 22
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
less
MGI:1924493, MGI:2143174
References
more
  • Summaries
    All 106
    Developmental Gene Expression 69
    Diseases 1
    Gene Ontology 13
    Phenotypes 16
  • Earliest
    J:63825 Meins M, et al., Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene. Genomics. 2000 Aug 1;67(3):317-32
  • Latest
    J:235628 Glasco DM, et al., The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Dev Biol. 2016 Sep 1;417(1):40-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory