Tbx20
Gene Detail

Symbol Name ID

Tbx20 T-box 20 MGI:1888496

Synonyms

9430010M06Rik, Tbx12

Feature Type

protein coding gene

Genetic Map

Chromosome 9

10.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:24720812-24774303 bp, - strand From NCBI annotation of GRCm38   53492 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32476  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Tbx20

Human homologs

Human Homolog		TBX20, T-box 20
NCBI Gene ID		57057
neXtProt AC		NX_Q9UMR3
Human Synonyms		ASD4
Human Chr (Location)		7p14.3; chr7:35242042-35293711 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TBX20

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Homozygous null mice display embryonic lethality, impaired cardiac looping, a small hourglass shaped heart, and decreased cardiomyocyte proliferation.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (58 annotations)

Process	aortic valve development, aortic valve morphogenesis, ...
Component	cytoplasm, nucleus
Function	DNA binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (227)    Tissues (129)    Images (47)
Theiler Stages: 2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 17, 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	210
RT-PCR	17

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000031965 (Evidence)
Entrez Gene	57246 (Evidence)
UniGene	31452
DFCI	TC1585943, TC1591721, TC1609149, TC1609830, TC1620327
DoTS	DT.101161799, DT.101709523, DT.524196, DT.87029137, DT.94244052
NIA Mouse Gene Index	U030623
Consensus CDS Project	CCDS22933.1, CCDS52744.1
International Mouse Knockout Project Status	Tbx20

Sequences

Length	Strain/Species
genomic	57246	NCBI Gene Model | MGI Sequence Detail	53492	C57BL/6J
transcript	NM_194263	RefSeq | MGI Sequence Detail	6436	C57BL/6
polypeptide	Q9ES03	UniProt | EBI | MGI Sequence Detail	445	Not Applicable

All sequences(41) RefSeq(6) UniProt(1)

Polymorphisms

SNPs(407 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000016149	T-box transcription factor TBX20

Graphical View of Protein Domain Structure

References

(Earliest) J:63825 Meins M, et al., Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene. Genomics. 2000 Aug 1;67(3):317-32
(Latest) J:189611 Vrljicak P, et al., Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. PLoS One. 2012;7(7):e40815
All references(93)

Other accession IDs

MGI:1924493, MGI:2143174