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Lgi1
Gene Detail
 Symbol
Name
ID
Lgi1
leucine-rich repeat LGI family, member 1
MGI:1861691
Feature Type protein coding gene
Genetic Map
Chromosome 19
32.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:38264782-38308939 bp, + strand
From VEGA annotation of GRCm38

  44158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3737  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Lgi1

Human
homologs
Human Homolog LGI1, leucine-rich, glioma inactivated 1
NCBI Gene ID 9211
neXtProt AC  NX_O95970
Human Synonyms  ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
Human Chr (Location)  10q24; chr10:93757809-93798159 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LGI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit growth retardation, seizures, and death by the third week of life. Mice heterozygous for this allele exhibit increased suseptibility to pentylenetetrazole-induced seizures.
 
Human Diseases Modeled Using Mouse Lgi1 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Lgi1 interacts with 335 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process axon guidance, neuron projection development, ...
Component cell junction, extracellular region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (164)    Tissues (18)    Images (24)
Theiler Stages: 17, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 103
Western blot 16
RT-PCR 45
cDNA source data(3)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016342 (Evidence)
Ensembl Gene ModelENSMUSG00000067242 (Evidence)
Entrez Gene56839 (Evidence)
DFCITC1579786
DoTSDT.110802201, DT.111105024, DT.55115567, DT.55283272
NIA Mouse Gene IndexU019421, U252097
Consensus CDS ProjectCCDS29786.1
International Mouse Knockout Project StatusLgi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016342 VEGA Gene Model | MGI Sequence Detail 44158 C57BL/6J ±  kb
transcript OTTMUST00000039287 VEGA | MGI Sequence Detail 4259 Not Applicable 
polypeptide OTTMUSP00000017555 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR009039 EAR
InterPro IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000009779 leucine-rich glioma-inactivated protein 1
References (Earliest) J:63699 Somerville RP, et al., Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome. 2000 Aug;11(8):622-7
(Latest) J:204169 Ohkawa T, et al., Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci. 2013 Nov 13;33(46):18161-74
All references(39)
Disease annotation references (2)
Other
accession IDs
MGI:2147767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory