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Lgi1 Gene Detail
Summary
  • Symbol
    Lgi1
  • Name
    leucine-rich repeat LGI family, member 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861691
    NCBI Gene: 56839
  • Gene Overview
    MyGene.info: LGI1
Location & Maps
more
  • Sequence Map
    Chr19:38264536-38312214 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47679 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LGI1, leucine-rich, glioma inactivated 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LGI1, leucine-rich, glioma inactivated 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
  • Links
    NCBI Gene ID: 9211
    neXtProt AC: NX_O95970

  • Chr Location
    10q24; chr10:93757809-93798159 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3737
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: LGI1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lgi1 mouse models; 1 with human LGI1 associations

Human Disease Mouse Models
       Epilepsy, Familial Temporal Lobe, 1; ETL1   OMIM: 600512 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    6
  • Transgenic
    2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit growth retardation, seizures, and death by the third week of life. Mice heterozygous for this allele exhibit increased suseptibility to pentylenetetrazole-induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016342 VEGA Gene Model | MGI Sequence Detail 47679 C57BL/6J ±  kb
transcript OTTMUST00000039287 VEGA | MGI Sequence Detail 7780 Not Applicable  
polypeptide OTTMUSP00000017555 VEGA | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    103 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009779 leucine-rich glioma-inactivated protein 1
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 8
    cDNA 5
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147767
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Diseases 4
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:63699 Somerville RP, et al., Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome. 2000 Aug;11(8):622-7
  • Latest
    J:226077 Lovero KL, et al., The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4129-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory