Lgi1
Gene Detail

Symbol Name ID

Lgi1 leucine-rich repeat LGI family, member 1 MGI:1861691

Feature Type

protein coding gene

Genetic Map

Chromosome 19

32.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:38264782-38308939 bp, + strand From VEGA annotation of GRCm38   44158 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3737  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lgi1

Human homologs

Human Homolog		LGI1, leucine-rich, glioma inactivated 1
NCBI Gene ID		9211
neXtProt AC		NX_O95970
Human Synonyms		ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
Human Chr (Location)		10q24; chr10:95517566-95557916 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LGI1

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit growth retardation, seizures, and death by the third week of life. Mice heterozygous for this allele exhibit increased suseptibility to pentylenetetrazole-induced seizures.

 
Human Diseases Modeled Using Mouse Lgi1 (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	axon guidance, neuron projection development, ...
Component	cell junction, extracellular region, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (164)    Tissues (17)    Images (24)
Theiler Stages: 17, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	103
Western blot	16
RT-PCR	45

cDNA source data(3)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016342 (Evidence)
Ensembl Gene Model	ENSMUSG00000067242 (Evidence)
Entrez Gene	56839 (Evidence)
DFCI	TC1579786
DoTS	DT.110802201, DT.111105024, DT.55115567, DT.55283272
NIA Mouse Gene Index	U019421, U252097
Consensus CDS Project	CCDS29786.1
International Mouse Knockout Project Status	Lgi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016342	VEGA Gene Model | MGI Sequence Detail	44158	C57BL/6J
transcript	OTTMUST00000039287	VEGA | MGI Sequence Detail	4259	Not Applicable
polypeptide	OTTMUSP00000017555	VEGA | MGI Sequence Detail	557	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR009039	EAR
InterPro	IPR005492	Leucine-rich glioma-inactivated , EPTP repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000009779	leucine-rich glioma-inactivated protein 1

References

(Earliest) J:63699 Somerville RP, et al., Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome. 2000 Aug;11(8):622-7
(Latest) J:177918 Quille ML, et al., High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies. PLoS One. 2011;6(9):e25181
All references(37)

Other accession IDs

MGI:2147767