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Lgi1
Gene Detail
Symbol

Name
ID
Lgi1
leucine-rich repeat LGI family, member 1
MGI:1861691
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:38264782-38308939 bp, + strand
From VEGA annotation of GRCm38

  44158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3737  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: LGI1
Gene Tree: Lgi1

Human
homologs
LGI1, leucine-rich, glioma inactivated 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9211
neXtProt AC: NX_O95970

Human Synonyms: ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099

Human Chr (Location): 10q24; chr10:93757809-93798159 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LGI1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit growth retardation, seizures, and death by the third week of life. Mice heterozygous for this allele exhibit increased suseptibility to pentylenetetrazole-induced seizures.
 
Human Diseases Modeled in Mice Using Lgi1 (1)    Mutations Annotated to Human Diseases (4)   
Interactions
Lgi1 interacts with 334 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process axon guidance, neuron projection development, ...
Component cell junction, extracellular region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (164)    Tissues (18)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Western blot 16
RT-PCR 45
cDNA source data(3)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lgi1 ; ZFIN lgi1a    NEW 
Molecular
reagents
All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016342 (Evidence)
Ensembl Gene Model ENSMUSG00000067242 (Evidence)
Entrez Gene 56839 (Evidence)
DFCI TC1579786
DoTS DT.111105024, DT.110802201, DT.55283272, DT.55115567
NIA Mouse Gene Index U252097, U019421
Consensus CDS Project CCDS29786.1
International Mouse Phenotyping Consortium Status Lgi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016342 VEGA Gene Model | MGI Sequence Detail 44158 C57BL/6J ±  kb
transcript OTTMUST00000039287 VEGA | MGI Sequence Detail 4259 Not Applicable 
polypeptide OTTMUSP00000017555 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR009039 EAR
InterPro IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000009779 leucine-rich glioma-inactivated protein 1
References
(Earliest) J:63699 Somerville RP, et al., Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome. 2000 Aug;11(8):622-7
(Latest) J:218750 Su LD, et al., LGI1 is Involved in the Development of Mouse Brain. Cerebellum. 2015 Feb;14(1):12-4
All references(38)
Disease annotation references (3)
Other
accession IDs
MGI:2147767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory