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Lgi1 Gene Detail
Summary
  • Symbol
    Lgi1
  • Name
    leucine-rich repeat LGI family, member 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861691
    NCBI Gene: 56839
  • Gene Overview
    MyGene.info: LGI1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:38264536-38312214 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47679 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.90 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LGI1, leucine rich glioma inactivated 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LGI1, leucine rich glioma inactivated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
  • Links
    NCBI Gene ID: 9211
    neXtProt AC: NX_O95970
    UniProt: O95970

  • Chr Location
    10q23.33; chr10:93757770-93798174 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3737
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LGI1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lgi1 mouse models; 1 with human LGI1 associations

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation, seizures, and death by the third week of life. Mice heterozygous for this allele exhibit increased suseptibility to pentylenetetrazole-induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016342 VEGA Gene Model | MGI Sequence Detail 47679 C57BL/6J ±  kb
    transcript OTTMUST00000039287 VEGA | MGI Sequence Detail 7780 Not Applicable  
    polypeptide OTTMUSP00000017555 VEGA | MGI Sequence Detail 557 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      103 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 6
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147767
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:63699 Somerville RP, et al., Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome. 2000 Aug;11(8):622-7
    • Latest
      J:261023 Zhou L, et al., Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. J Neurosci. 2018 Mar 28;38(13):3346-3357

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory