Lgi1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgi1
leucine-rich repeat LGI family, member 1
MGI:1861691

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lgi1^tm1.1Jkc/Lgi1⁺ Tyr^c-Brd/Tyr^c-Brd B6.Cg-Tyr^c-Brd Lgi1^tm1.1Jkc	abnormal eye pigmentation	J:158715
	absent coat pigmentation	J:158715
Lgi1^tm1.1Jkc/Lgi1^tm1.1Jkc Tyr^c-Brd/Tyr^c-Brd B6.Cg-Tyr^c-Brd Lgi1^tm1.1Jkc	abnormal coat/hair pigmentation	J:158715
	abnormal eye pigmentation	J:158715
	clonic seizures	J:158715
	decreased body size	J:158715
	enhanced AMPA-mediated synaptic currents	J:158715
	enhanced NMDA-mediated synaptic currents	J:158715
	increased miniature excitatory postsynaptic current frequency	J:158715
	normal nervous system phenotype	J:158715
	postnatal lethality, complete penetrance	J:158715
	seizures	J:158715
Tg(Lgi1)#Mpan/0 Not Specified	abnormal axon pruning	J:154129
	abnormal dendrite morphology	J:154129
	abnormal miniature excitatory postsynaptic currents	J:154129
	abnormal paired-pulse facilitation	J:154129
	abnormal synaptic transmission	J:154129
	decreased excitatory postsynaptic current amplitude	J:154129
Tg(Lgi1*)#Mpan/0 Not Specified	abnormal axon pruning	J:154129
	abnormal CNS synaptic transmission	J:154129
	abnormal dendrite morphology	J:154129
	abnormal miniature excitatory postsynaptic currents	J:154129
	abnormal paired-pulse inhibition	J:154129
	abnormal synapse morphology	J:154129
	abnormal synaptic transmission	J:154129
	increased excitatory postsynaptic current amplitude	J:154129
	increased susceptibility to pharmacologically induced seizures	J:154129

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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