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Rab27a
Gene Detail
 Symbol
Name
ID
Rab27a
RAB27A, member RAS oncogene family
MGI:1861441
Synonyms 2210402C08Rik, 2410003M20Rik, 4933437C11Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:73044854-73097629 bp, + strand
From VEGA annotation of GRCm38

  52776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab27a

Human
homologs
Human Homolog RAB27A, RAB27A, member RAS oncogene family
NCBI Gene ID 5873
neXtProt AC  NX_P51159
Human Synonyms  GS2, HsT18676, RAB27, RAM
Human Chr (Location)  15q15-q21.1; chr15:55202966-55289832 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAB27A
Alleles
and
phenotypes
All alleles(157) : Targeted(3) Gene trapped(151) Spontaneous(2) Chemically induced(1)
 
Homozygotes have abnormal melanocyte development producing abnormal pigmentation and a gray coat color.
 
Human Diseases Modeled Using Mouse Rab27a (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process antigen processing and presentation, blood coagulation, ...
Component apical plasma membrane, dendrite, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (10)    Images (6)
Theiler Stages: 2, 3, 23
Assay TypeResults
RNA in situ 22
RT-PCR 36
cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000044792 (Evidence)
Ensembl Gene ModelENSMUSG00000032202 (Evidence)
Entrez Gene11891 (Evidence)
UniGene34867
DFCITC1578123, TC1589271, TC1622649
DoTSDT.101364311, DT.50315373, DT.91340747
NIA Mouse Gene IndexU010734
PDB3BC1
Consensus CDS ProjectCCDS23335.1
International Mouse Knockout Project StatusRab27a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044792 VEGA Gene Model | MGI Sequence Detail 52776 C57BL/6J ±  kb
transcript OTTMUST00000117733 VEGA | MGI Sequence Detail 3168 Not Applicable 
polypeptide OTTMUSP00000065780 VEGA | MGI Sequence Detail 221 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(379 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013600 ras-related protein Rab-27A
References (Earliest) J:13720 Phillips RJS, Description of the phenotypes of p-alleles (other than p) held at Harwell - correction. Mouse News Lett. 1977;57:18
(Latest) J:202776 Hou Y, et al., EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells. J Biol Chem. 2013 Jul 5;288(27):19548-57
All references(103)
Other
accession IDs
MGD-MRK-1419, MGI:1918454, MGI:1919226, MGI:1922923, MGI:88083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory