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Rab27a
Gene Detail
Symbol

Name
ID
Rab27a
RAB27A, member RAS oncogene family
MGI:1861441
Synonyms
2210402C08Rik, 2410003M20Rik, 4933437C11Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:73044854-73098501 bp, + strand
From VEGA annotation of GRCm38

  53648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAB27A
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab27a

Human
homologs
RAB27A, RAB27A, member RAS oncogene family
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5873
neXtProt AC: NX_P51159

Human Synonyms: GS2, HsT18676, RAB27, RAM

Human Chr (Location): 15q15-q21.1; chr15:55202966-55289828 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RAB27A

Mutations,
alleles, and
phenotypes
All mutations/alleles(159) : Chemically induced (ENU)(3) Gene trapped(151) Spontaneous(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes have abnormal melanocyte development producing abnormal pigmentation and a gray coat color.
 
Human Diseases Modeled in Mice Using Rab27a (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Rab27a interacts with 213 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process antigen processing and presentation, blood coagulation, ...
Component apical plasma membrane, cell, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (10)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
RT-PCR 36
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rab27a    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000044792 (Evidence)
Ensembl Gene Model ENSMUSG00000032202 (Evidence)
Entrez Gene 11891 (Evidence)
DFCI TC1622649, TC1589271, TC1578123, TC1697967
DoTS DT.97341497, DT.91340747, DT.50315373, DT.101364311
NIA Mouse Gene Index U010734
PDB 3BC1
Consensus CDS Project CCDS23335.1
International Mouse Phenotyping Consortium Status Rab27a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044792 VEGA Gene Model | MGI Sequence Detail 53648 C57BL/6J ±  kb
transcript OTTMUST00000117733 VEGA | MGI Sequence Detail 3168 Not Applicable 
polypeptide OTTMUSP00000065780 VEGA | MGI Sequence Detail 221 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(380 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013600 ras-related protein Rab-27A
References
(Earliest) J:13720 Phillips RJS, Description of the phenotypes of p-alleles (other than p) held at Harwell - correction. Mouse News Lett. 1977;57:18
(Latest) J:211540 Singh RK, et al., Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J. 2013 Feb;280(3):892-903
All references(105)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1419, MGI:1918454, MGI:1919226, MGI:1922923, MGI:88083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory