Rab27a
Gene Detail

Symbol Name ID

Rab27a RAB27A, member RAS oncogene family MGI:1861441

Synonyms

2210402C08Rik, 2410003M20Rik, 4933437C11Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:73044865-73097592 bp, + strand From NCBI annotation of GRCm38   52728 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab27a

Human homologs

Human Homolog		RAB27A, RAB27A, member RAS oncogene family
NCBI Gene ID		5873
neXtProt AC		NX_P51159
Human Synonyms		GS2, HsT18676, RAB27, RAM
Human Chr (Location)		15q15-q21.1; chr15:55495164-55582013 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RAB27A

Alleles and phenotypes

All alleles(157) : Targeted(3) Gene trapped(151) Spontaneous(2) Chemically induced(1)
 

Homozygotes have abnormal melanocyte development producing abnormal pigmentation and a gray coat color.

 
Human Diseases Modeled Using Mouse Rab27a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	blood coagulation, cytotoxic T cell degranulation, ...
Component	apical plasma membrane, dendrite, ...
Function	GDP binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (10)    Images (6)
Theiler Stages: 2, 3, 23

Assay Type	Results
RNA in situ	22
RT-PCR	36

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000032202 (Evidence)
Entrez Gene	11891 (Evidence)
UniGene	480676
DFCI	TC1578123, TC1589271, TC1622649
DoTS	DT.101364311, DT.50315373, DT.91340747
NIA Mouse Gene Index	U010734
PDB	3BC1
Consensus CDS Project	CCDS23335.1
International Mouse Knockout Project Status	Rab27a

Sequences

Length	Strain/Species
genomic	11891	NCBI Gene Model | MGI Sequence Detail	52728	C57BL/6J
transcript	NM_023635	RefSeq | MGI Sequence Detail	2971	C57BL/6
polypeptide	Q9ERI2	UniProt | EBI | MGI Sequence Detail	221	Not Applicable

All sequences(37) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(203 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013600	ras-related protein Rab-27A

Graphical View of Protein Domain Structure

References

(Earliest) J:13720 Phillips RJS, Description of the phenotypes of p-alleles (other than p) held at Harwell - correction. Mouse News Lett. 1977;57:18
(Latest) J:193137 Sepulveda FE, et al., Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013 Jan 24;121(4):595-603
All references(94)

Other accession IDs

MGD-MRK-1419, MGI:1918454, MGI:1919226, MGI:1922923, MGI:88083