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Avpr1a Gene Detail
Summary
  • Symbol
    Avpr1a
  • Name
    arginine vasopressin receptor 1A
  • Synonyms
    V1aR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859216
    NCBI Gene: 54140
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:122448499-122453452 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 70.36 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859216
protein coding gene Chr10:122448499-122453453 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017789
protein coding gene Chr10:125745137-125750095 (+)
A/J MGP_AJ_G0017764
protein coding gene Chr10:120738661-120743613 (+)
AKR/J MGP_AKRJ_G0017727
protein coding gene Chr10:124358776-124363732 (+)
BALB/cJ MGP_BALBcJ_G0017728
protein coding gene Chr10:121148423-121153376 (+)
C3H/HeJ MGP_C3HHeJ_G0017552
protein coding gene Chr10:124524043-124528997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018183
protein coding gene Chr10:130006452-130011406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015863
protein coding gene Chr10:115015756-115020664 (+)
CAST/EiJ MGP_CASTEiJ_G0017112
protein coding gene Chr10:124935210-124940213 (+)
CBA/J MGP_CBAJ_G0017521
protein coding gene Chr10:135314749-135319703 (+)
DBA/2J MGP_DBA2J_G0017627
protein coding gene Chr10:119880028-119884982 (+)
FVB/NJ MGP_FVBNJ_G0017622
protein coding gene Chr10:118853747-118858701 (+)
LP/J MGP_LPJ_G0017701
protein coding gene Chr10:126284985-126289943 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017650
protein coding gene Chr10:137845508-137850462 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018223
protein coding gene Chr10:124382109-124387049 (+)
PWK/PhJ MGP_PWKPhJ_G0016897
protein coding gene Chr10:119985817-119990903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016688
protein coding gene Chr10:123300845-123305722 (+)
WSB/EiJ MGP_WSBEiJ_G0017173
protein coding gene Chr10:124575197-124580151 (+)



Homology
more
  • Human Ortholog
    AVPR1A, arginine vasopressin receptor 1A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AVPR1A, arginine vasopressin receptor 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AVPR1, AVPR V1a, V1aR
  • Links
    NCBI Gene ID: 552
    neXtProt AC: NX_P37288
    UniProt: P37288

  • Chr Location
    12q14.2; chr12:63142759-63152810 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Avpr1a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a stimulus processing deficit similar to that seen in schizophrenia. Anxiety-like behaviors are reduced in males but not females. B cell development is also affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020123 Ensembl Gene Model | MGI Sequence Detail 4954 C57BL/6J ±  kb
    transcript ENSMUST00000020323 Ensembl | MGI Sequence Detail 2670 Not Applicable  
    polypeptide ENSMUSP00000020323 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 6
      Phenotypes 35
    • Earliest
      J:75961 Wesley VJ, et al., Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. Biochemistry. 2002 Apr 23;41(16):5086-92
    • Latest
      J:264677 Koshimizu TA, et al., Complex formation between the vasopressin 1b receptor, beta-arrestin-2, and the mu-opioid receptor underlies morphine tolerance. Nat Neurosci. 2018 Jun;21(6):820-833

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory