Avpr1a
Gene Detail

Symbol Name ID

Avpr1a arginine vasopressin receptor 1A MGI:1859216

Synonyms

V1aR

Feature Type

protein coding gene

Genetic Map

Chromosome 10

70.36 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:122448499-122453453 bp, + strand From VEGA annotation of GRCm38   4955 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Avpr1a ± 2 cM)

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Avpr1a

Human ortholog

AVPR1A arginine vasopressin receptor 1A NCBI Gene ID 552
Human Synonyms: AVPR1, AVPR V1a, V1aR
Human Chr12:63540216-63546590 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display a stimulus processing deficit similar to that seen in schizophrenia. Anxiety-like behaviors are reduced in males but not females. B cell development is also affected.

 
Human Diseases Modeled Using Mouse Avpr1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	calcium-mediated signaling, elevation of cytosolic calcium ion concentration, ...
Component	cytoplasmic vesicle, integral to membrane, ...
Function	G-protein coupled receptor activity, peptide hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (146)    Tissues (76)    Images (27)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	56
In situ reporter (knock in)	52
RT-PCR	38

cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020920 (Evidence)
Ensembl Gene Model	ENSMUSG00000020123 (Evidence)
Entrez Gene	54140 (Evidence)
UniGene	4351
DFCI	TC1583605
DoTS	DT.487709
NIA Mouse Gene Index	U086756
Consensus CDS Project	CCDS24215.1
International Mouse Knockout Project Status	Avpr1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020920	VEGA Gene Model | MGI Sequence Detail	4955	C57BL/6J
transcript	OTTMUST00000049450	VEGA | MGI Sequence Detail	2671	Not Applicable
polypeptide	OTTMUSP00000022915	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015076	Domain of unknown function DUF1856
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001817	Vasopressin receptor
InterPro	IPR001224	Vasopressin V1A receptor
Protein Ontology	PR:000001681	vasopressin V1a receptor

References

(Earliest) J:75961 Wesley VJ, et al., Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. Biochemistry. 2002 Apr 23;41(16):5086-92
(Latest) J:192500 Hammock EA, et al., Modulation of parvalbumin interneuron number by developmentally transient neocortical vasopressin receptor 1a (V1aR). Neuroscience. 2012 Oct 11;222:20-8
All references(58)