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Avpr1a Gene Detail
Summary
  • Symbol
    Avpr1a
  • Name
    arginine vasopressin receptor 1A
  • Synonyms
    V1aR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859216
    NCBI Gene: 54140
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:122284404-122289357 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 70.36 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859216
 protein coding gene Chr10:122284404-122289358 (+)
129S1/SvImJ ENSMUSG00200024820
 protein coding gene Chr10:118627786-118632743 (+)
A/J ENSMUSG00195020794
 protein coding gene Chr10:119067858-119072810 (+)
AKR/J ENSMUSG00220014693
 protein coding gene Chr10:118695772-118700728 (+)
BALB/cJ ENSMUSG00180016694
 protein coding gene Chr10:119058995-119063947 (+)
C3H/HeJ ENSMUSG00175024005
 protein coding gene Chr10:119069172-119074125 (+)
C57BL/6NJ ENSMUSG00215012168
 protein coding gene Chr10:118697503-118702456 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015863
 protein coding gene Chr10:115015756-115020664 (+)
CAST/EiJ ENSTCUG00005030623
 protein coding gene Chr10:118024643-118029647 (+)
CBA/J ENSMUSG00210021050
 protein coding gene Chr10:118904798-118909751 (+)
DBA/2J ENSMUSG00185008079
 protein coding gene Chr10:119014598-119019551 (+)
FVB/NJ ENSMUSG00205016485
 protein coding gene Chr10:118328561-118333514 (+)
JF1/MsJ ENSUMUG00000010444
 protein coding gene Chr10:120314888-120319851 (+)
LP/J ENSMUSG00230021578
 protein coding gene Chr10:120955393-120960350 (+)
NOD/ShiLtJ ENSMUSG00190017287
 protein coding gene Chr10:119112598-119117551 (+)
NZO/HlLtJ ENSMUSG00225036275
 protein coding gene Chr10:125193862-125198801 (+)
PWK/PhJ ENSLUMG00010012373
 protein coding gene Chr10:118720346-118725321 (+)
SPRET/EiJ ENSMSPG00010015193
 protein coding gene Chr10:120627096-120631157 (+)
WSB/EiJ ENSIUOG00005013476
 protein coding gene Chr10:118717960-118722914 (+)



Homology
more
  • Human Ortholog
    AVPR1A, arginine vasopressin receptor 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AVPR1A, arginine vasopressin receptor 1A
  • Synonyms
    AVPR1, AVPR V1a, V1aR
  • Links
    NCBI Gene ID: 552
    UniProt: P37288

  • Chr Location
    12q14.2; chr12:63142759-63151201 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Avpr1a mouse models; 1 with human AVPR1A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 6 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a stimulus processing deficit similar to that seen in schizophrenia. Anxiety-like behaviors are reduced in males but not females. B cell development is also affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    84
  • cDNA Data
    15
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020123 Ensembl Gene Model | MGI Sequence Detail 4954 C57BL/6J ±  kb
    transcript ENSMUST00000020323 Ensembl | MGI Sequence Detail 2670 Not Applicable  
    polypeptide ENSMUSP00000020323 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 9
      Phenotypes 63
    • Earliest
      J:75961 Wesley VJ, et al., Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. Biochemistry. 2002 Apr 23;41(16):5086-92
    • Latest
      J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory