Pdcd7 MGI Mouse Gene Detail - MGI:1859170

Symbol

Pdcd7
Name

programmed cell death 7
Synonyms

ES18

Feature Type

protein coding gene
IDs

MGI:1859170
NCBI Gene: 50996
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:65253386-65266925 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.25 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

27 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859170	protein coding gene	Chr9:65253350-65266925 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034954	protein coding gene	Chr9:65073125-65087310 (+)
A/J	MGP_AJ_G0034934	protein coding gene	Chr9:62882326-62895389 (+)
AKR/J	MGP_AKRJ_G0034864	protein coding gene	Chr9:64366751-64381460 (+)
BALB/cJ	MGP_BALBcJ_G0034927	protein coding gene	Chr9:62605472-62619020 (+)
C3H/HeJ	MGP_C3HHeJ_G0034637	protein coding gene	Chr9:64894258-64909200 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035446	protein coding gene	Chr9:66842094-66856646 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032357	protein coding gene	Chr9:62531054-62544977 (+)
CAST/EiJ	MGP_CASTEiJ_G0033958	protein coding gene	Chr9:65083671-65096633 (+)
CBA/J	MGP_CBAJ_G0034608	protein coding gene	Chr9:69180809-69196398 (+)
DBA/2J	MGP_DBA2J_G0034767	protein coding gene	Chr9:62653373-62666405 (+)
FVB/NJ	MGP_FVBNJ_G0034709	protein coding gene	Chr9:61976239-61989241 (+)
LP/J	MGP_LPJ_G0034850	protein coding gene	Chr9:65347040-65360104 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034751	protein coding gene	Chr9:70411909-70425765 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035468	protein coding gene	Chr9:64467005-64480307 (+)
PWK/PhJ	MGP_PWKPhJ_G0033662	protein coding gene	Chr9:62856525-62869875 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033496	protein coding gene	Chr9:64756836-64769999 (+)
WSB/EiJ	MGP_WSBEiJ_G0034071	protein coding gene	Chr9:64366885-64380812 (+)

Human Ortholog

PDCD7, programmed cell death 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDCD7, programmed cell death 7
Synonyms

59K, ES18, HES18
Links

HGNC:8767

NCBI Gene ID: 10081

neXtProt AC: NX_Q8N8D1

UniProt: Q8N8D1
Chr Location

15q22.31; chr15:65117379-65133808 (-) GRCh38

MGI Vertebrate Homology

Pdcd7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDCD7
Gene Tree

Pdcd7

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Targeted

2
Genomic Mutations

1 involving Pdcd7
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

14
cDNA Data

46
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdcd7

ZFIN pdcd7

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All Sequences

43
RefSeq

2
UniProt

4
CCDS

CCDS40670.1

Ensembl

ENSMUSG00000041837 (Evidence)
NCBI Gene

50996

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041837	Ensembl Gene Model \| MGI Sequence Detail	13540	C57BL/6J	± kb
transcript	ENSMUST00000048184	Ensembl \| MGI Sequence Detail	2419	Not Applicable
polypeptide	ENSMUSP00000035515	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012459 programmed cell death protein 7

(term hierarchy)
InterPro Domains

IPR031974 Programmed cell death protein 7

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All nucleic 46

cDNA 46

Microarray probesets 2

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MGI:2143411

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 10
Earliest

J:53789 Ritzel MW, et al., Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol. 1998 Oct-Dec;15(4):203-11
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Pdcd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85690	Chr9:65253348-65253359 (+)	-32 bp
Tssr85691	Chr9:65253373-65253411 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23