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Olig2
Gene Detail
Symbol

Name
ID
Olig2
oligodendrocyte transcription factor 2
MGI:1355331
Synonyms
Bhlhb1, bHLHe19, Olg-2, RK17
Feature Type
protein coding gene
Genetic Map
Chromosome 16
52.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:91225550-91228677 bp, + strand
From VEGA annotation of GRCm38

  3128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OLIG2
Gene Tree: Olig2

Human
homologs
OLIG2, oligodendrocyte lineage transcription factor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10215
neXtProt AC: NX_Q13516

Human Synonyms: BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17

Human Chr (Location): 21q22.11; chr21:33025908-33029196 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(15) Targeted(14)
Genomic Mutations involving Olig2 (5)
Incidental mutations (data from CvDC )
 
Homozygous mutation of this gene results in neonatal lethality, impaired development of motoneurons and oligodendrocytes, aphagia, hypotonia, and abnormal posture and breathing.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Olig2 interacts with 183 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process multicellular organismal development, myelination, ...
Component cytoplasm, nucleus, ...
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (332 records)
Data Summary: Results (402)    Tissues (234)    Images (129)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 57
RNA in situ 315
Northern blot 12
RT-PCR 18
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN olig2    NEW 
Molecular
reagents
All nucleic(31) cDNA(17) Primer pair(3) Other(11)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019873 (Evidence)
Ensembl Gene Model ENSMUSG00000039830 (Evidence)
Entrez Gene 50913 (Evidence)
UniGene 37289
DFCI TC1578873
DoTS DT.40138538
NIA Mouse Gene Index U017367
Consensus CDS Project CCDS28323.1
International Mouse Phenotyping Consortium Status Olig2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019873 VEGA Gene Model | MGI Sequence Detail 3128 C57BL/6J ±  kb
transcript OTTMUST00000047388 VEGA | MGI Sequence Detail 2437 Not Applicable 
polypeptide OTTMUSP00000021402 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000011632 oligodendrocyte transcription factor 2
References
(Earliest) J:60687 Zhou Q, et al., Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 Feb;25(2):331-43
(Latest) J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22
All references(420)
Other
accession IDs
MGI:2146463

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory