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Olig2 Gene Detail
Summary
  • Symbol
    Olig2
  • Name
    oligodendrocyte transcription factor 2
  • Synonyms
    Bhlhb1, bHLHe19, Olg-2, RK17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355331
    NCBI Gene: 50913
  • Gene Overview
    MyGene.info: OLIG2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91225550-91228677 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 52.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355331
protein coding gene Chr16:91225457-91228677 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023036
protein coding gene Chr16:92224610-92227737 (+)
A/J MGP_AJ_G0023004
protein coding gene Chr16:87917865-87920992 (+)
AKR/J MGP_AKRJ_G0022974
protein coding gene Chr16:90563254-90566381 (+)
BALB/cJ MGP_BALBcJ_G0023006
protein coding gene Chr16:88436448-88439575 (+)
C3H/HeJ MGP_C3HHeJ_G0022767
protein coding gene Chr16:91131992-91135119 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023453
protein coding gene Chr16:95210285-95213412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020955
protein coding gene Chr16:85625775-85628910 (+)
CAST/EiJ MGP_CASTEiJ_G0022286
protein coding gene Chr16:91690677-91693815 (+)
CBA/J MGP_CBAJ_G0022736
protein coding gene Chr16:99264341-99267480 (+)
DBA/2J MGP_DBA2J_G0022870
protein coding gene Chr16:87819327-87822454 (+)
FVB/NJ MGP_FVBNJ_G0022844
protein coding gene Chr16:86947269-86950396 (+)
LP/J MGP_LPJ_G0022940
protein coding gene Chr16:91932737-91935864 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022865
protein coding gene Chr16:103843312-103846439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023471
protein coding gene Chr16:91079161-91082288 (+)
PWK/PhJ MGP_PWKPhJ_G0022031
protein coding gene Chr16:87993636-87996775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021861
protein coding gene Chr16:90635776-90638887 (+)
WSB/EiJ MGP_WSBEiJ_G0022338
protein coding gene Chr16:91327888-91331015 (+)



Homology
more
  • Human Ortholog
    OLIG2, oligodendrocyte transcription factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OLIG2, oligodendrocyte transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17
  • Links
    NCBI Gene ID: 10215
    neXtProt AC: NX_Q13516
    UniProt: Q13516

  • Chr Location
    21q22.11; chr21:33025908-33029196 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4241
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OLIG2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 5 genetic backgrounds
    50 phenotypes from multigenic genotypes
    143 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in neonatal lethality, impaired development of motoneurons and oligodendrocytes, aphagia, hypotonia, and abnormal posture and breathing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50913 NCBI Gene Model | MGI Sequence Detail 3128 C57BL/6J ±  kb
    transcript NM_016967 RefSeq | MGI Sequence Detail 2462 C57BL/6  
    polypeptide Q9EQW6 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011632 oligodendrocyte transcription factor 2
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032658 Oligodendrocyte transcription factor 2
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 19
      Primer pair 4
      Other 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146463
    References
    more
    • Summaries
      All 589
      Developmental Gene Expression 448
      Diseases 2
      Gene Ontology 15
      Phenotypes 143
    • Earliest
      J:55331 Murray NR, et al., Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J Cell Biol. 1999 May 17;145(4):699-711
    • Latest
      J:266544 Kim J, et al., Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory