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Olig2 Gene Detail
Summary
  • Symbol
    Olig2
  • Name
    oligodendrocyte transcription factor 2
  • Synonyms
    Bhlhb1, bHLHe19, Olg-2, RK17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355331
    NCBI Gene: 50913
  • Gene Overview
    MyGene.info: OLIG2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:91225550-91228677 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3128 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 52.60 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    OLIG2, oligodendrocyte transcription factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OLIG2, oligodendrocyte transcription factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17
  • Links
    NCBI Gene ID: 10215
    neXtProt AC: NX_Q13516
    UniProt: Q13516

  • Chr Location
    21q22.11; chr21:33025908-33029196 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4241
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OLIG2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 5 genetic backgrounds
    50 phenotypes from multigenic genotypes
    141 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in neonatal lethality, impaired development of motoneurons and oligodendrocytes, aphagia, hypotonia, and abnormal posture and breathing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019873 VEGA Gene Model | MGI Sequence Detail 3128 C57BL/6J ±  kb
    transcript OTTMUST00000047388 VEGA | MGI Sequence Detail 2437 Not Applicable  
    polypeptide OTTMUSP00000021402 VEGA | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      10 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011632 oligodendrocyte transcription factor 2
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032658 Oligodendrocyte transcription factor 2
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 19
      Primer pair 4
      Other 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146463
    References
    more
    • Summaries
      All 585
      Developmental Gene Expression 444
      Diseases 2
      Gene Ontology 15
      Phenotypes 141
    • Earliest
      J:55331 Murray NR, et al., Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J Cell Biol. 1999 May 17;145(4):699-711
    • Latest
      J:264806 Sandberg M, et al., Genomic analysis of transcriptional networks directing progression of cell states during MGE development. Neural Dev. 2018 Sep 14;13(1):21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory