Olig2
Gene Detail

Symbol Name ID

Olig2 oligodendrocyte transcription factor 2 MGI:1355331

Synonyms

Bhlhb1, bHLHe19, Olg-2, RK17

Feature Type

protein coding gene

Genetic Map

Chromosome 16

52.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:91225550-91228677 bp, + strand From VEGA annotation of GRCm38   3128 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Olig2

Human homologs

Human Homolog		OLIG2, oligodendrocyte lineage transcription factor 2
NCBI Gene ID		10215
neXtProt AC		NX_Q13516
Human Synonyms		BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17
Human Chr (Location)		21q22.11; chr21:34398216-34401504 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(9) Gene trapped(15)
 

Homozygous mutation of this gene results in neonatal lethality, impaired development of motoneurons and oligodendrocytes, aphagia, hypotonia, and abnormal posture and breathing.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	multicellular organismal development, myelination, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (266 records)
Data Summary: Results (278)    Tissues (169)    Images (73)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	233
RT-PCR	18

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(17) Primer pair(3) Other(5)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019873 (Evidence)
Ensembl Gene Model	ENSMUSG00000039830 (Evidence)
Entrez Gene	50913 (Evidence)
UniGene	37289
DFCI	TC1578873
DoTS	DT.40138538
NIA Mouse Gene Index	U017367
Consensus CDS Project	CCDS28323.1
International Mouse Knockout Project Status	Olig2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019873	VEGA Gene Model | MGI Sequence Detail	3128	C57BL/6J
transcript	OTTMUST00000047388	VEGA | MGI Sequence Detail	2437	Not Applicable
polypeptide	OTTMUSP00000021402	VEGA | MGI Sequence Detail	323	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000011632	oligodendrocyte transcription factor 2

References

(Earliest) J:60687 Zhou Q, et al., Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 Feb;25(2):331-43
(Latest) J:194649 Kako E, et al., Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative. Stem Cells. 2012 Oct;30(10):2234-47
All references(340)

Other accession IDs

MGI:2146463