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Olig2
Gene Detail
 Symbol
Name
ID
Olig2
oligodendrocyte transcription factor 2
MGI:1355331
Synonyms Bhlhb1, bHLHe19, Olg-2, RK17
Feature Type protein coding gene
Genetic Map
Chromosome 16
52.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:91225550-91228677 bp, + strand
From VEGA annotation of GRCm38

  3128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Olig2

Human
homologs
Human Homolog OLIG2, oligodendrocyte lineage transcription factor 2
NCBI Gene ID 10215
neXtProt AC  NX_Q13516
Human Synonyms  BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17
Human Chr (Location)  21q22.11; chr21:33025908-33029196 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(15) Targeted(12)
Genomic Mutations involving Olig2 (3)
 
Homozygous mutation of this gene results in neonatal lethality, impaired development of motoneurons and oligodendrocytes, aphagia, hypotonia, and abnormal posture and breathing.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Olig2 interacts with 183 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process multicellular organismal development, myelination, ...
Component cytoplasm, nucleus, ...
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (296 records)
Data Summary: Results (372)    Tissues (230)    Images (103)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 313
Northern blot 12
RT-PCR 18
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(17) Primer pair(3) Other(11)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019873 (Evidence)
Ensembl Gene ModelENSMUSG00000039830 (Evidence)
Entrez Gene50913 (Evidence)
UniGene37289
DFCITC1578873
DoTSDT.40138538
NIA Mouse Gene IndexU017367
Consensus CDS ProjectCCDS28323.1
International Mouse Knockout Project StatusOlig2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019873 VEGA Gene Model | MGI Sequence Detail 3128 C57BL/6J ±  kb
transcript OTTMUST00000047388 VEGA | MGI Sequence Detail 2437 Not Applicable 
polypeptide OTTMUSP00000021402 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000011632 oligodendrocyte transcription factor 2
References (Earliest) J:60687 Zhou Q, et al., Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 Feb;25(2):331-43
(Latest) J:212006 Fancy SP, et al., Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci. 2014 Apr;17(4):506-12
All references(383)
Other
accession IDs
MGI:2146463

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory