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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Olig2
oligodendrocyte transcription factor 2
MGI:1355331
79 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Acvr1tm1Mak/\Acvr1+
\Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/\Gt(ROSA)26Sor+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129 * C57BL/6 		increased oligodendrocyte number J:285841
\Acvr1tm1Mak/\Acvr1+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal brain development J:285841
abnormal brainstem morphology J:285841
abnormal glial cell physiology J:285841
ataxia J:285841
muscle spasm J:285841
normal neoplasm J:285841
preweaning lethality, incomplete penetrance J:285841
\Acvr1tm1Mak/\Acvr1+
\Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/\Gt(ROSA)26Sor+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129 * C57BL/6 * FVB/N 		increased brain tumor incidence J:285841
increased glioma incidence J:285841
\Acvr1tm1Mak/\Acvr1+
\Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/\Gt(ROSA)26Sor+
\H3c2tm1Mak/\H3c2+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129 * C57BL/6 * FVB/N 		increased brain tumor incidence J:285841
increased glioma incidence J:285841
\Acvr1tm1Mak/\Acvr1+
\H3c2tm1Mak/\H3c2+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		normal neoplasm J:285841
postnatal lethality, incomplete penetrance J:285841
\Cdh2tm1Glr/\Cdh2tm1Glr
\Olig2tm1(cre)Tmj/\Olig2+
involves: 129S6/SvEvTac 		abnormal neuronal migration J:178688
abnormal spinal cord morphology J:178688
abnormal spinal cord motor column morphology J:178688
lethality throughout fetal growth and development, incomplete penetrance J:178688
neonatal lethality, complete penetrance J:178688
\Cspg4tm1Ychan/\Cspg4tm1Ychan
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129 * C57BL/6N 		decreased body weight J:184220
decreased epididymal fat pad weight J:184220
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Juptm1Ruiz/\Juptm1.1Tmj
\Olig2tm1(cre)Tmj/\Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal dendrite morphology J:178688
lethality throughout fetal growth and development, complete penetrance J:178688
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Juptm1Ruiz/\Juptm1Ruiz
\Olig2tm1(cre)Tmj/\Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal neuronal migration J:178688
abnormal spinal cord lateral motor column morphology J:178688
abnormal spinal cord medial motor column morphology J:178688
abnormal spinal cord motor column morphology J:178688
abnormal ventral interneuron 1 morphology J:178688
abnormal ventral interneuron 2 morphology J:178688
decreased motor neuron number J:178688
embryonic lethality during organogenesis, complete penetrance J:178688
normal nervous system phenotype J:178688
\Ctnnb1tm2Kem/\Ctnnb1tm2Kem
\Olig2tm1(cre)Tmj/\Olig2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal spinal cord medial motor column morphology J:178688
decreased motor neuron number J:178688
neonatal lethality, complete penetrance J:178688
\Gt(ROSA)26Sorem2(Mios)Bcgen/\Gt(ROSA)26Sor+
\Miostm1Pfw/\Miostm1Pfw
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129 * C57BL/6 		normal nervous system phenotype J:320720
\Gt(ROSA)26Sortm1(Hoxa2)Fmr/\Gt(ROSA)26Sor+
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129P2/OlaHsd 		abnormal brain development J:193058
decreased oligodendrocyte progenitor number J:193058
\Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/\Gt(ROSA)26Sor+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129 * C57BL/6 * FVB/N 		normal neoplasm J:285841
\Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/\Gt(ROSA)26Sor+
\H3c2tm1Mak/\H3c2+
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129 * C57BL/6 * FVB/N 		normal neoplasm J:285841
\Gt(ROSA)26Sortm1(Smo/EYFP)Amc/\Gt(ROSA)26Sortm1(Smo/EYFP)Amc
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129 * 129X1/SvJ 		increased medulloblastoma incidence J:139574
premature death J:139574
\Mapttm1(Sema3e)Yuyo/\Mapt+
\Olig2tm1(cre)Tmj/\Olig2+
Not Specified 		abnormal excitatory postsynaptic potential J:205528
abnormal sensory neuron innervation pattern J:205528
abnormal synaptic bouton morphology J:205528
normal nervous system phenotype J:205528
\Miostm1Pfw/\Miostm1Pfw
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129 * C57BL/6 		abnormal oligodendrocyte physiology J:320720
normal behavior/neurological phenotype J:320720
decreased oligodendrocyte number J:320720
dysmyelination J:320720
\Myrftm1Barr/\Myrftm1Barr
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal myelination J:150563
abnormal optic nerve morphology J:150563
abnormal spinal cord morphology J:150563
ataxia J:150563
normal nervous system phenotype J:150563
postnatal lethality, complete penetrance J:150563
seizures J:150563
tremors J:150563
\Ntf3tm2.1Jae/\Ntf3tm2Jae
\Olig2tm2(cre)Htak/\Olig2+
involves: ICR 		abnormal dorsal root ganglion morphology J:182750
abnormal proprioceptive neuron morphology J:182750
abnormal sensory neuron innervation pattern J:182750
\Olig1tm1And/\Olig1tm1And
\Olig2tm1And/\Olig2tm1And
involves: 129 * C57BL/6J 		abnormal nervous system development J:76446
abnormal ventral interneuron 2 morphology J:76446
absent oligodendrocytes J:76446
decreased fetal size J:76446
decreased motor neuron number J:76446
decreased oligodendrocyte progenitor number J:76446
perinatal lethality, complete penetrance J:76446
\Olig1tm1And/\Olig1tm1And
\Olig2tm1And/\Olig2tm1And
\Tg(Olig2)#Wdr/?
Not Specified 		abnormal oligodendrocyte morphology J:210099
\Olig2tm1(cre)Tmj/\Olig2+
\Shhtm2Amc/\Shhtm2Amc
involves: 129S1/Sv * 129X1/SvJ 		abnormal spinal cord lateral motor column morphology J:277700
decreased motor neuron number J:277700
normal nervous system phenotype J:277700
\Olig2tm1(cre)Tmj/\Olig2+
\Smn1tm1Jme/\Smn1tm1Msd
\Grm7Tg(SMN2)89Ahmb/\Grm7+
involves: 129 * 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:164292
\Olig2tm1(cre)Tmj/\Olig2+
\Smn1tm1Jme/\Smn1tm1Msd
\Grm7Tg(SMN2)89Ahmb/\Grm7Tg(SMN2)89Ahmb
involves: 129 * 129P2/OlaHsd * FVB/N 		abnormal CNS synaptic transmission J:164292
abnormal miniature endplate potential J:164292
abnormal muscle morphology J:164292
abnormal neuromuscular synapse morphology J:164292
abnormal PNS synaptic transmission J:164292
abnormal sensory neuron innervation pattern J:164292
abnormal synaptic bouton morphology J:164292
abnormal synaptic transmission J:164292
decreased body weight J:164292
decreased grip strength J:164292
decreased skeletal muscle fiber number J:164292
decreased survivor rate J:164292
increased skeletal muscle fiber size J:164292
kyphosis J:164292
motor neuron degeneration J:164292
muscle weakness J:164292
muscular atrophy J:164292
premature death J:164292
skeletal muscle fiber degeneration J:164292
\Polr3atm1Iwil/\Polr3atm1Iwil
\Olig2tm1.1(cre)Wdr/\Olig2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal brain white matter morphology J:311745
abnormal object recognition memory J:311745
abnormal oligodendrocyte physiology J:311745
abnormal spatial reference memory J:311745
decreased body size J:311745
decreased body weight J:311745
decreased myelin sheath thickness J:311745
decreased oligodendrocyte number J:311745
decreased startle reflex J:311745
dysmyelination J:311745
increased thermal nociceptive threshold J:311745
motor developmental delay J:311745
slow postnatal weight gain J:311745
\Prrc2atm1Fcw/\Prrc2atm1Fcw
\Olig2tm2(TVA,cre)Rth/\Olig2+
involves: 129 * C57BL/6 		abnormal brain morphology J:301796
abnormal corpus callosum morphology J:301796
decreased body weight J:301796
decreased grip strength J:301796
decreased oligodendrocyte number J:301796
decreased oligodendrocyte progenitor number J:301796
dysmyelination J:301796
enlarged lateral ventricles J:301796
impaired coordination J:301796
impaired spatial learning J:301796
increased brain weight J:301796
normal nervous system phenotype J:301796
premature death J:301796
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory