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Exosc10 Gene Detail
Summary
  • Symbol
    Exosc10
  • Name
    exosome component 10
  • Synonyms
    p2, p3, p4, PM-Scl, PM/Scl-100, Pmscl2, RRP6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355322
    NCBI Gene: 50912
  • Gene Overview
    MyGene.info: EXOSC10
Location & Maps
more
  • Sequence Map
    Chr4:148558429-148582401 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23973 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.76 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EXOSC10, exosome component 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOSC10, exosome component 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p2, p3, p4, PM-Scl, PMSCL, PM/Scl-100, PMSCL2, RRP6, Rrp6p
  • Links
    NCBI Gene ID: 5394
    neXtProt AC: NX_Q01780

  • Chr Location
    1p36.22; chr1:11066613-11099910 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
  • All Mutations and Alleles
    23
  • Gene trapped
    19
  • Targeted
    4
  • Genomic Mutations
    1 involving Exosc10
  • Incidental Mutations
Mice homozygous for a conditional allele appear phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010937 VEGA Gene Model | MGI Sequence Detail 23973 C57BL/6J ±  kb
transcript OTTMUST00000025653 VEGA | MGI Sequence Detail 2790 Not Applicable  
polypeptide OTTMUSP00000011757 VEGA | MGI Sequence Detail 887 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    245 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 153
    Genomic 1
    cDNA 152

    Microarray probesets 6
References
more
  • Summaries
    All 35
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:61080 Bliskovski V, et al., Structure and localization of mouse pmscl1 and pmscl2 genes. Genomics. 2000 Feb 15;64(1):106-10
  • Latest
    J:223317 Pefanis E, et al., RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity. Cell. 2015 May 7;161(4):774-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory