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Exosc10
Gene Detail
Symbol

Name
ID
Exosc10
exosome component 10
MGI:1355322
Synonyms
p2, p3, p4, PM-Scl, PM/Scl-100, Pmscl2, RRP6
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148558429-148582401 bp, + strand
From VEGA annotation of GRCm38

  23973 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31105  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EXOSC10
Gene Tree: Exosc10

Human
homologs
EXOSC10, exosome component 10
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5394
neXtProt AC: NX_Q01780

Human Synonyms: p2, p3, p4, PM-Scl, PMSCL, PM/Scl-100, PMSCL2, RRP6, Rrp6p

Human Chr (Location): 1p36.22; chr1:11066613-11099910 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(19) Targeted(4)
Genomic Mutations involving Exosc10 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Exosc10 interacts with 145 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cellular metabolic process, CUT catabolic process, ...
Component cytoplasm, exosome (RNase complex), ...
Function 3'-5' exonuclease activity, 3'-5'-exoribonuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(152)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase exosc10 ; ZFIN exosc10    NEW 
Molecular
reagents
All nucleic(153) Genomic(1) cDNA(152)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000010937 (Evidence)
Ensembl Gene Model ENSMUSG00000017264 (Evidence)
Entrez Gene 50912 (Evidence)
UniGene 266635
DFCI TC1595510, TC1587080, TC1572668, TC1768810, TC1670138
DoTS DT.97383027, DT.94287401, DT.101219032, DT.493831, DT.110784031, DT.101377336
NIA Mouse Gene Index U005087
EC 3.1.13.-
Consensus CDS Project CCDS18939.1
International Mouse Phenotyping Consortium Status Exosc10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010937 VEGA Gene Model | MGI Sequence Detail 23973 C57BL/6J ±  kb
transcript OTTMUST00000025653 VEGA | MGI Sequence Detail 2790 Not Applicable 
polypeptide OTTMUSP00000011757 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(14) UniProt(10)
Polymorphisms
SNPs within 2kb(248 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002562 3'-5' exonuclease domain
InterPro IPR012588 Exosome-associated factor Rrp6, N-terminal
InterPro IPR002121 HRDC domain
InterPro IPR010997 HRDC-like
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000007258 exosome component 10
References
(Earliest) J:61080 Bliskovski V, et al., Structure and localization of mouse pmscl1 and pmscl2 genes. Genomics. 2000 Feb 15;64(1):106-10
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory