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Exosc10 Gene Detail
Summary
  • Symbol
    Exosc10
  • Name
    exosome component 10
  • Synonyms
    p2, p3, p4, PM-Scl, PM/Scl-100, Pmscl2, RRP6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355322
    NCBI Gene: 50912
  • Gene Overview
    MyGene.info: EXOSC10
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148558429-148582401 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355322
protein coding gene Chr4:148558422-148582401 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029126
protein coding gene Chr4:152295943-152319811 (+)
A/J MGP_AJ_G0029091
protein coding gene Chr4:145992236-146016034 (+)
AKR/J MGP_AKRJ_G0029039
protein coding gene Chr4:149965870-149990789 (+)
BALB/cJ MGP_BALBcJ_G0029107
protein coding gene Chr4:146494872-146518729 (+)
C3H/HeJ MGP_C3HHeJ_G0028828
protein coding gene Chr4:150528836-150553547 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029556
protein coding gene Chr4:157824100-157847950 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026802
protein coding gene Chr4:138409486-138433491 (+)
CAST/EiJ MGP_CASTEiJ_G0028241
protein coding gene Chr4:147737683-147761554 (+)
CBA/J MGP_CBAJ_G0028790
protein coding gene Chr4:162397728-162440112 (+)
DBA/2J MGP_DBA2J_G0028939
protein coding gene Chr4:146096932-146120905 (+)
FVB/NJ MGP_FVBNJ_G0028903
protein coding gene Chr4:145189152-145214059 (+)
LP/J MGP_LPJ_G0029029
protein coding gene Chr4:152248319-152275318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028930
protein coding gene Chr4:165717543-165742550 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029588
protein coding gene Chr4:150453233-150483304 (+)
PWK/PhJ MGP_PWKPhJ_G0027961
protein coding gene Chr4:142088051-142112382 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027795
protein coding gene Chr4:144709570-144735817 (+)
WSB/EiJ MGP_WSBEiJ_G0028321
protein coding gene Chr4:150621532-150645400 (+)



Homology
more
  • Human Ortholog
    EXOSC10, exosome component 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOSC10, exosome component 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p2, p3, p4, PM-Scl, PMSCL, PM/Scl-100, PMSCL2, RRP6, Rrp6p
  • Links
    NCBI Gene ID: 5394
    neXtProt AC: NX_Q01780
    UniProt: Q01780

  • Chr Location
    1p36.22; chr1:11066613-11099910 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous for a conditional allele appear phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017264 Ensembl Gene Model | MGI Sequence Detail 23973 C57BL/6J ±  kb
transcript ENSMUST00000017408 Ensembl | MGI Sequence Detail 2790 Not Applicable  
polypeptide ENSMUSP00000017408 Ensembl | MGI Sequence Detail 887 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 154
    Genomic 1
    cDNA 153

    Microarray probesets 6
References
more
  • Summaries
    All 38
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:61080 Bliskovski V, et al., Structure and localization of mouse pmscl1 and pmscl2 genes. Genomics. 2000 Feb 15;64(1):106-10
  • Latest
    J:253584 Jamin SP, et al., EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. Sci Rep. 2017 Nov 8;7(1):15065

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory