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Exosc10
Gene Detail
 Symbol
Name
ID
Exosc10
exosome component 10
MGI:1355322
Synonyms p2, p3, p4, PM-Scl, PM/Scl-100, Pmscl2, RRP6
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148558429-148582401 bp, + strand
From VEGA annotation of GRCm38

  23973 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31105  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Exosc10

Human
homologs
Human Homolog EXOSC10, exosome component 10
NCBI Gene ID 5394
neXtProt AC  NX_Q01780
Human Synonyms  p2, p3, p4, PM-Scl, PMSCL, PM/Scl-100, PMSCL2, RRP6, Rrp6p
Human Chr (Location)  1p36.22; chr1:11066618-11099904 (-)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Gene trapped(19) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular metabolic process, CUT catabolic process, ...
Component cytoplasm, exosome (RNase complex), ...
Function 3'-5' exonuclease activity, 3'-5'-exoribonuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(152)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(153) Genomic(1) cDNA(152)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000010937 (Evidence)
Ensembl Gene ModelENSMUSG00000017264 (Evidence)
Entrez Gene50912 (Evidence)
UniGene266635
DFCITC1572668, TC1587080, TC1595510, TC1670138, TC1768810
DoTSDT.101219032, DT.101377336, DT.110784031, DT.493831, DT.94287401, DT.97383027
NIA Mouse Gene IndexU005087
EC3.1.13.-
Consensus CDS ProjectCCDS18939.1
International Mouse Knockout Project StatusExosc10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010937 VEGA Gene Model | MGI Sequence Detail 23973 C57BL/6J ±  kb
transcript OTTMUST00000025653 VEGA | MGI Sequence Detail 2790 Not Applicable 
polypeptide OTTMUSP00000011757 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(14) UniProt(10)
Polymorphisms SNPs within 2kb(248 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002562 3'-5' exonuclease domain
InterPro IPR012588 Exosome-associated factor Rrp6, N-terminal
InterPro IPR002121 HRDC domain
InterPro IPR010997 HRDC-like
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000007258 exosome component 10
References (Earliest) J:61080 Bliskovski V, et al., Structure and localization of mouse pmscl1 and pmscl2 genes. Genomics. 2000 Feb 15;64(1):106-10
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory