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Pttg1
Gene Detail
Symbol

Name
ID
Pttg1
pituitary tumor-transforming gene 1
MGI:1353578
Synonyms
PTTG, securin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
25.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:43420250-43426251 bp, - strand
From VEGA annotation of GRCm38

  6002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3110  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PTTG1
Gene Tree: Pttg1

Human
homologs
PTTG1, pituitary tumor-transforming 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9232
neXtProt AC: NX_O95997

Human Synonyms: EAP1, HPTTG, PTTG, TUTR1

Human Chr (Location): 5q35.1; chr5:160421807-160428744 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(6) Targeted(9)
 
Mice homozygous for a knock-out allele show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, chromosome instability, premature centromere division, reduced female fertility, reduced pancreatic beta cell mass and sexually-dimorphic diabetes.
 
Interactions
Pttg1 interacts with 142 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, nucleus
Function cysteine-type endopeptidase inhibitor activity, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (61)    Tissues (58)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
cDNA source data(117)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN pttg1    NEW 
Molecular
reagents
All nucleic(118) cDNA(117) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005453 (Evidence)
Ensembl Gene Model ENSMUSG00000020415 (Evidence)
Entrez Gene 30939 (Evidence)
UniGene 6856
DFCI TC1576018, TC1588171, TC1695491
DoTS DT.101397332, DT.495426, DT.87051219, DT.94367063
NIA Mouse Gene Index U032676
Consensus CDS Project CCDS24556.1, CCDS48771.1
International Mouse Phenotyping Consortium Status Pttg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005453 VEGA Gene Model | MGI Sequence Detail 6002 C57BL/6J ±  kb
transcript OTTMUST00000012141 VEGA | MGI Sequence Detail 741 Not Applicable 
polypeptide OTTMUSP00000005608 VEGA | MGI Sequence Detail 199 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006940 Securin sister-chromatid separation inhibitor
InterPro IPR018008 Securin sister-chromatid separation inhibitor, metazoan
Protein Ontology PR:000013486 securin
References
(Earliest) J:60182 Wang Z, et al., Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter. Endocrinology. 2000 Feb;141(2):763-71
(Latest) J:212096 Keeley PW, et al., Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9295-300
All references(75)
Other
accession IDs
MGI:2144572, MGI:2147417

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory