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Pttg1 Gene Detail
Summary
  • Symbol
    Pttg1
  • Name
    pituitary tumor-transforming gene 1
  • Synonyms
    PTTG, securin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353578
    NCBI Gene: 30939
  • Gene Overview
    MyGene.info: PTTG1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:43420248-43426248 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 25.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353578
protein coding gene Chr11:43420248-43426251 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018171
protein coding gene Chr11:42176812-42186264 (-)
A/J MGP_AJ_G0018143
protein coding gene Chr11:40573190-40579178 (-)
AKR/J MGP_AKRJ_G0018107
protein coding gene Chr11:41762931-41768929 (-)
BALB/cJ MGP_BALBcJ_G0018112
protein coding gene Chr11:40759858-40766015 (-)
C3H/HeJ MGP_C3HHeJ_G0017925
protein coding gene Chr11:41794215-41801452 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018566
protein coding gene Chr11:43477841-43484973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016221
protein coding gene Chr11:38644582-38649958 (-)
CAST/EiJ MGP_CASTEiJ_G0017489
protein coding gene Chr11:41847501-41855266 (-)
CBA/J MGP_CBAJ_G0017898
protein coding gene Chr11:45473038-45482836 (-)
DBA/2J MGP_DBA2J_G0018008
protein coding gene Chr11:40363017-40369921 (-)
FVB/NJ MGP_FVBNJ_G0018002
protein coding gene Chr11:40049337-40056097 (-)
LP/J MGP_LPJ_G0018080
protein coding gene Chr11:42430626-42437422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018026
protein coding gene Chr11:47126213-47132093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018605
protein coding gene Chr11:41917088-41923944 (-)
PWK/PhJ MGP_PWKPhJ_G0017270
protein coding gene Chr11:40382598-40388609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017062
protein coding gene Chr11:41710671-41716525 (-)
WSB/EiJ MGP_WSBEiJ_G0017538
protein coding gene Chr11:41557267-41564547 (-)



Homology
more
  • Human Ortholog
    PTTG1, pituitary tumor-transforming 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTTG1, pituitary tumor-transforming 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAP1, HPTTG, PTTG, TUTR1
  • Links
    NCBI Gene ID: 9232
    neXtProt AC: NX_O95997
    UniProt: O95997

  • Chr Location
    5q33.3; chr5:160421807-160428744 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3110
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PTTG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, chromosome instability, premature centromere division, reduced female fertility, reduced pancreatic betacell mass and sexually-dimorphic diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30939 NCBI Gene Model | MGI Sequence Detail 6001 C57BL/6J ±  kb
    transcript NM_013917 RefSeq | MGI Sequence Detail 1694 Not Specified  
    polypeptide Q9CQJ7 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 118
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144572, MGI:2147417
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 14
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256001 Jung EM, et al., Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory