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Pttg1 Gene Detail
Summary
  • Symbol
    Pttg1
  • Name
    pituitary tumor-transforming gene 1
  • Synonyms
    PTTG, securin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353578
    NCBI Gene: 30939
  • Gene Overview
    MyGene.info: PTTG1
Location & Maps
more
  • Sequence Map
    Chr11:43420250-43426251 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6002 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 25.68 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PTTG1, pituitary tumor-transforming 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTTG1, pituitary tumor-transforming 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EAP1, HPTTG, PTTG, TUTR1
  • Links
    NCBI Gene ID: 9232
    neXtProt AC: NX_O95997

  • Chr Location
    5q35.1; chr5:160421807-160428744 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Pttg1
Mice homozygous for a knock-out allele show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, chromosome instability, premature centromere division, reduced female fertility, reduced pancreatic betacell mass and sexually-dimorphic diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005453 VEGA Gene Model | MGI Sequence Detail 6002 C57BL/6J ±  kb
transcript OTTMUST00000012141 VEGA | MGI Sequence Detail 741 Not Applicable  
polypeptide OTTMUSP00000005608 VEGA | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    152 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013486 securin
  • InterPro Domains
    IPR006940 Securin sister-chromatid separation inhibitor
    IPR018008 Securin sister-chromatid separation inhibitor, metazoan
Molecular
Reagents
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  • All nucleic 118
    cDNA 117
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2144572, MGI:2147417
References
more
  • Summaries
    All 73
    Developmental Gene Expression 13
    Gene Ontology 7
    Phenotypes 30
  • Earliest
    J:60182 Wang Z, et al., Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter. Endocrinology. 2000 Feb;141(2):763-71
  • Latest
    J:212096 Keeley PW, et al., Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9295-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory