Rhdrox2 QTL Detail

Summary

• Symbol
  Rhdrox2
• Name
  response to hydroxyurea 2, mean life span

• Feature Type
  QTL
• IDs
  MGI:7314894
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

References

• Summaries
  All 1
• Earliest
  J:306895 Brown A, et al., The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function. Haematologica. 2020;105(2):317-324

Candidate Genes for Rhdrox2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Pttg1	Chr11:43311077-43317078 (-)	J:306895	By generating and analyzing reciprocal congenic mice for this locus, the authors demonstrate that the Rhdrox1/Rhdrox2 region indeed determines the sensitivity of hematopoietic stem and progenitor cells to hydroxyurea. The authors verified pituitary tumor-transforming gene 1 (Pttg1; MGI:1353578) as the quantitative trait gene regulating the differential response of hematopoietic stem and progenitor cells to hydroxyurea treatment and which might therefore be linked to the regulation of lifespan.