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Foxe1
Gene Detail
Symbol

Name
ID
Foxe1
forkhead box E1
MGI:1353500
Synonyms
thyroid transcription factor 2, Titf2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
24.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:46343609-46346412 bp, + strand
From VEGA annotation of GRCm38

  2804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXE1
Gene Tree: Foxe1

Human
homologs
FOXE1, forkhead box E1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2304
neXtProt AC: NX_O00358

Human Synonyms: FKHL15, FOXE2, HFKH4, HFKL5, TITF2, TTF2, TTF-2

Human Chr (Location): 9q22; chr9:97853255-97856715 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FOXE1

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice die within 48 hours of birth exhibiting cleft palate and a sublingual or absent thyroid gland due to thyroid dysgenesis at the stage of endodermal bud migration. Mutant skin grafts display thin, sparse and kinky pelage hairs due to defects in late hair follicle morphogenesis.
 
Human Diseases Modeled in Mice Using Foxe1 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Foxe1 interacts with 110 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell differentiation, cell migration, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (59)    Tissues (21)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 43
RNA in situ 14
RT-PCR 2
cDNA source data(7)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase foxe1 ; ZFIN foxe1    NEW 
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000006884 (Evidence)
Ensembl Gene Model ENSMUSG00000070990 (Evidence)
Entrez Gene 110805 (Evidence)
UniGene 389547
DFCI TC1627187, TC1635499
DoTS DT.40145994, DT.101708459
NIA Mouse Gene Index U104954, U025030
Consensus CDS Project CCDS18147.1
International Mouse Phenotyping Consortium Status Foxe1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006884 VEGA Gene Model | MGI Sequence Detail 2804 C57BL/6J ±  kb
transcript OTTMUST00000015897 VEGA | MGI Sequence Detail 2804 Not Applicable 
polypeptide OTTMUSP00000007303 VEGA | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007619 forkhead box protein E1
References
(Earliest) J:41061 Zannini M, et al., TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997 Jun 2;16(11):3185-97
(Latest) J:200722 Hick AC, et al., Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013 Sep 1;381(1):227-40
All references(46)
Disease annotation references (2)
Other
accession IDs
MGI:894329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory