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Foxe1 Gene Detail
Summary
  • Symbol
    Foxe1
  • Name
    forkhead box E1
  • Synonyms
    thyroid transcription factor 2, Titf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353500
    NCBI Gene: 110805
  • Gene Overview
    MyGene.info: FOXE1
Location & Maps
more
  • Sequence Map
    Chr4:46343609-46346412 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2804 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 24.68 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FOXE1, forkhead box E1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOXE1, forkhead box E1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL15, FOXE2, HFKH4, HFKL5, NMTC4, TITF2, TTF2, TTF-2
  • Links
    NCBI Gene ID: 2304
    neXtProt AC: NX_O00358

  • Chr Location
    9q22.33; chr9:97853255-97856715 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Foxe1 mouse models; 2 with human FOXE1 associations

Human Disease Mouse Models
       Hypothyroidism, Thyroidal or Athyroidal, with Spiky Hair and Cleft Palate   OMIM: 241850 View 1 model
       Hypothyroidism, Congenital, Nongoitrous, 2; CHNG2   OMIM: 218700 View 1 model
       Thyroid Cancer, Nonmedullary, 4; NMTC4   OMIM: 616534
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die within 48 hours of birth exhibiting cleft palate and a sublingual or absent thyroid gland due to thyroid dysgenesis at the stage of endodermal bud migration. Mutant skin grafts display thin, sparse and kinky pelage hairs due to defects in late hair follicle morphogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006884 VEGA Gene Model | MGI Sequence Detail 2804 C57BL/6J ±  kb
transcript OTTMUST00000015897 VEGA | MGI Sequence Detail 2804 Not Applicable  
polypeptide OTTMUSP00000007303 VEGA | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 11
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:894329
References
more
  • Summaries
    All 47
    Developmental Gene Expression 23
    Diseases 2
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:41061 Zannini M, et al., TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997 Jun 2;16(11):3185-97
  • Latest
    J:234818 Nikitski A, et al., Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. Endocrinology. 2016 May;157(5):2182-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory