About   Help   FAQ
Foxe1
Gene Detail
 Symbol
Name
ID
Foxe1
forkhead box E1
MGI:1353500
Synonyms thyroid transcription factor 2, Titf2
Feature Type protein coding gene
Genetic Map
Chromosome 4
24.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:46343609-46346412 bp, + strand
From VEGA annotation of GRCm38

  2804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Foxe1

Human
homologs
Human Homolog FOXE1, forkhead box E1 (thyroid transcription factor 2)
NCBI Gene ID 2304
neXtProt AC  NX_O00358
Human Synonyms  FKHL15, FOXE2, HFKH4, HFKL5, TITF2, TTF2, TTF-2
Human Chr (Location)  9q22; chr9:97853255-97856715 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXE1
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die within 48 hours of birth exhibiting cleft palate and a sublingual or absent thyroid gland due to thyroid dysgenesis at the stage of endodermal bud migration. Mutant skin grafts display thin, sparse and kinky pelage hairs due to defects in late hair follicle morphogenesis.
 
Human Diseases Modeled Using Mouse Foxe1 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Foxe1 interacts with 110 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process axon extension involved in axon guidance, cell migration, ...
Component nucleus, transcription factor complex
Function DNA binding, DNA binding, bending, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (53)    Tissues (16)    Images (23)
Theiler Stages: 14, 15, 16, 17, 18, 20, 22, 26, 28
Assay TypeResults
Immunohistochemistry 43
RNA in situ 8
RT-PCR 2
cDNA source data(6)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006884 (Evidence)
Ensembl Gene ModelENSMUSG00000070990 (Evidence)
Entrez Gene110805 (Evidence)
UniGene389547
DFCITC1627187, TC1635499
DoTSDT.101708459, DT.40145994
NIA Mouse Gene IndexU025030, U104954
Consensus CDS ProjectCCDS18147.1
International Mouse Knockout Project StatusFoxe1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006884 VEGA Gene Model | MGI Sequence Detail 2804 C57BL/6J ±  kb
transcript OTTMUST00000015897 VEGA | MGI Sequence Detail 2804 Not Applicable 
polypeptide OTTMUSP00000007303 VEGA | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007619 forkhead box protein E1
References (Earliest) J:41061 Zannini M, et al., TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997 Jun 2;16(11):3185-97
(Latest) J:200722 Hick AC, et al., Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013 Sep 1;381(1):227-40
All references(48)
Disease annotation references (2)
Other
accession IDs
MGI:894329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory