Foxe1
Gene Detail

Symbol Name ID

Foxe1 forkhead box E1 MGI:1353500

Synonyms

thyroid transcription factor 2, Titf2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

24.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:46343609-46346412 bp, + strand From VEGA annotation of GRCm38   2804 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Foxe1

Human homologs

Human Homolog		FOXE1, forkhead box E1 (thyroid transcription factor 2)
NCBI Gene ID		2304
neXtProt AC		NX_O00358
Human Synonyms		FKHL15, FOXE2, HFKH4, HFKL5, TITF2, TTF2, TTF-2
Human Chr (Location)		9q22; chr9:100615537-100618997 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXE1

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice die within 48 hours of birth exhibiting cleft palate and a sublingual or absent thyroid gland due to thyroid dysgenesis at the stage of endodermal bud migration. Mutant skin grafts display thin, sparse and kinky pelage hairs due to defects in late hair follicle morphogenesis.

 
Human Diseases Modeled Using Mouse Foxe1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cell migration, embryonic organ morphogenesis, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (13)    Tissues (6)    Images (7)
Theiler Stages: 15, 20, 22, 26

Assay Type	Results
Immunohistochemistry	3
RNA in situ	8
RT-PCR	2

cDNA source data(6)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000006884 (Evidence)
Ensembl Gene Model	ENSMUSG00000070990 (Evidence)
Entrez Gene	110805 (Evidence)
UniGene	389547
DFCI	TC1627187, TC1635499
DoTS	DT.101708459, DT.40145994
NIA Mouse Gene Index	U025030, U104954
Consensus CDS Project	CCDS18147.1
International Mouse Knockout Project Status	Foxe1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006884	VEGA Gene Model | MGI Sequence Detail	2804	C57BL/6J
transcript	OTTMUST00000015897	VEGA | MGI Sequence Detail	2804	Not Applicable
polypeptide	OTTMUSP00000007303	VEGA | MGI Sequence Detail	371	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007619	forkhead box protein E1

References

(Earliest) J:41061 Zannini M, et al., TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997 Jun 2;16(11):3185-97
(Latest) J:176192 Hayashi S, et al., Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
All references(46)

Other accession IDs

MGI:894329