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Phenotypes Associated with This Genotype
Genotype
MGI:3587185
Allelic
Composition
Foxe1tm1Rdl/Foxe1tm1Rdl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxe1tm1Rdl mutation (1 available); any Foxe1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice died within 48 hours of birth

endocrine/exocrine glands
• at E9.5, the thyroid primordium remains contiguous with the pharyngeal endoderm and does not begin to migrate downward
• at E11.5, half the thyroid cell precursors remain in the position of the primordium and the other half are undetectable
• at E15.5, these unmigrated cells differentiate into a small, ectopic thymus located sublingually
• thyroid gland absent from the normal location

craniofacial
• palatal shelves are unable to fuse; coronal sections through the palatal region of newborn mutant mice shows that the palatal shelves do not meet at the midline
• severe

homeostasis/metabolism
• compensatory elevation of thyroid-stimulating hormone present, indicating normal pituitary response
• absence of thyroid hormones in the blood

digestive/alimentary system
• palatal shelves are unable to fuse; coronal sections through the palatal region of newborn mutant mice shows that the palatal shelves do not meet at the midline
• severe

integument
• on grafted skin, the hair coat appears sparse and thin
• on grafted skin, the hair coat appears kinky
• on grafted skin, hairs are kinky, curly, thin and have abnormal septation between cells
• 50% reduction in hair with 3-5 cell layers, increase in single cell layers
• on grafted skin, hairs have a distinct C- or S-shaped curvature
• on grafted skin, hair follicles are misaligned and smaller than controls
• differentiation and proliferation of grafted skin is normal

growth/size/body
• palatal shelves are unable to fuse; coronal sections through the palatal region of newborn mutant mice shows that the palatal shelves do not meet at the midline
• severe


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory