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Akr1b3 Gene Detail
Summary
  • Symbol
    Akr1b3
  • Name
    aldo-keto reductase family 1, member B3 (aldose reductase)
  • Synonyms
    Ahr1, Ahr-1, Aldor1, Aldr1, ALR2, AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353494
    NCBI Gene: 11677
  • Gene Overview
    MyGene.info: AKR1B1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr6:34303930-34317489 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 14.87 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353494
protein coding gene Chr6:34302434-34317489 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030556
protein coding gene Chr6:32372657-32387492 (-)
A/J MGP_AJ_G0030529
protein coding gene Chr6:30996092-31011132 (-)
AKR/J MGP_AKRJ_G0030456
protein coding gene Chr6:32035343-32050651 (-)
BALB/cJ MGP_BALBcJ_G0030539
protein coding gene Chr6:31177748-31192788 (-)
C3H/HeJ MGP_C3HHeJ_G0030252
protein coding gene Chr6:31997625-32012665 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030993
protein coding gene Chr6:33185080-33200669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028204
protein coding gene Chr6:29087685-29102706 (-)
CAST/EiJ MGP_CASTEiJ_G0029654
protein coding gene Chr6:31792984-31831262 (-)
CBA/J MGP_CBAJ_G0030230
protein coding gene Chr6:34461052-34479668 (-)
DBA/2J MGP_DBA2J_G0030374
protein coding gene Chr6:30871135-30886580 (-)
FVB/NJ MGP_FVBNJ_G0030328
protein coding gene Chr6:30658544-30675673 (-)
LP/J MGP_LPJ_G0030461
protein coding gene Chr6:32495839-32511203 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030364
protein coding gene Chr6:36815330-36832705 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031023
protein coding gene Chr6:31918901-31934795 (-)
PWK/PhJ MGP_PWKPhJ_G0029368
protein coding gene Chr6:30482068-30497679 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029204
protein coding gene Chr6:31561838-31579190 (-)
WSB/EiJ MGP_WSBEiJ_G0029730
protein coding gene Chr6:31834706-31852818 (-)



Homology
more
  • Human Ortholog
    AKR1B1, aldo-keto reductase family 1 member B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AKR1B1, aldo-keto reductase family 1 member B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADR, ALDR1, ALR2, AR
  • Links
    NCBI Gene ID: 231
    neXtProt AC: NX_P15121
    UniProt: P15121

  • Chr Location
    7q33; chr7:134442352-134459136 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased drinking, increased urination, and dilation of the renal tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11677 NCBI Gene Model | MGI Sequence Detail 13560 C57BL/6J ±  kb
    transcript NM_009658 RefSeq | MGI Sequence Detail 1402 C57BL/6  
    polypeptide P45376 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 7
      cDNA 18

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1225, MGD-MRK-1229, MGD-MRK-29060, MGI:104906, MGI:1329017
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 44
    • Earliest
      J:7000 Duley JA, et al., Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3. Biochem Genet. 1982 Dec;20(11-12):1067-83
    • Latest
      J:264629 Yuan C, et al., Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice. Diabetes. 2018 Sep;67(9):1880-1891

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory