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Akr1b3 Gene Detail
Summary
  • Symbol
    Akr1b3
  • Name
    aldo-keto reductase family 1, member B3 (aldose reductase)
  • Synonyms
    Ahr1, Ahr-1, Aldor1, Aldr1, ALR2, AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353494
    NCBI Gene: 11677
  • Gene Overview
    MyGene.info: AKR1B1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:34302434-34317478 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15045 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 14.87 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AKR1B1, aldo-keto reductase family 1 member B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AKR1B1, aldo-keto reductase family 1 member B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADR, ALDR1, ALR2, AR
  • Links
    NCBI Gene ID: 231
    neXtProt AC: NX_P15121
    UniProt: P15121

  • Chr Location
    7q33; chr7:134442352-134459136 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased drinking, increased urination, and dilation of the renal tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014776 VEGA Gene Model | MGI Sequence Detail 15045 C57BL/6J ±  kb
    transcript OTTMUST00000035069 VEGA | MGI Sequence Detail 1387 Not Applicable  
    polypeptide OTTMUSP00000015654 VEGA | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      133 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 7
      cDNA 17

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1225, MGD-MRK-1229, MGD-MRK-29060, MGI:104906, MGI:1329017
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 41
    • Earliest
      J:7000 Duley JA, et al., Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3. Biochem Genet. 1982 Dec;20(11-12):1067-83
    • Latest
      J:254950 Thiagarajan D, et al., Aldose reductase modulates acute activation of mesenchymal markers via the beta-catenin pathway during cardiac ischemia-reperfusion. PLoS One. 2017;12(11):e0188981

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory