Akr1b3
Gene Detail

Symbol Name ID

Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) MGI:1353494

Synonyms

Ahr1, Ahr-1, Aldor1, Aldr1, ALR2, AR

Feature Type

protein coding gene

Genetic Map

Chromosome 6

14.87 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:34303934-34317497 bp, - strand From VEGA annotation of GRCm38   13564 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110647  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 4 chicken; 1 zebrafish

Protein SuperFamily: AKR
Gene Tree: Akr1b3

Human homologs

Human Homolog		AKR1B1, aldo-keto reductase family 1, member B1 (aldose reductase)
NCBI Gene ID		231
neXtProt AC		NX_P15121
Human Synonyms		ADR, ALDR1, ALR2, AR
Human Chr (Location)		7q35; chr7:134127107-134143888 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mutation of this gene results in increased drinking, increased urination, and dilation of the renal tubules.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	daunorubicin metabolic process, doxorubicin metabolic process, ...
Component	cytoplasm, extracellular space, ...
Function	alditol:NADP+ 1-oxidoreductase activity, glyceraldehyde oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (113)    Tissues (111)    Images (15)
Theiler Stages: 22, 24, 28

Assay Type	Results
RNA in situ	103
Northern blot	10

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(7) cDNA(17)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000014776 (Evidence)
Ensembl Gene Model	ENSMUSG00000001642 (Evidence)
Entrez Gene	11677 (Evidence)
DoTS	DT.101377110, DT.495566, DT.91597078, DT.94127579, DT.94339696
NIA Mouse Gene Index	U021342, U027147, U046396, U066376
EC	1.1.1.21
Consensus CDS Project	CCDS19990.1
International Mouse Knockout Project Status	Akr1b3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014776	VEGA Gene Model | MGI Sequence Detail	13564	C57BL/6J
transcript	OTTMUST00000035069	VEGA | MGI Sequence Detail	1406	Not Applicable
polypeptide	OTTMUSP00000015654	VEGA | MGI Sequence Detail	316	Not Applicable

All sequences(86) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(130 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001395	Aldo/keto reductase
InterPro	IPR018170	Aldo/keto reductase, conserved site
InterPro	IPR020471	Aldo/keto reductase subgroup
InterPro	IPR023210	NADP-dependent oxidoreductase domain
Protein Ontology	PR:000003901	aldose reductase

References

(Earliest) J:7000 Duley JA, et al., Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3. Biochem Genet. 1982 Dec;20(11-12):1067-83
(Latest) J:189107 Abdillahi M, et al., Aldose reductase modulates cardiac glycogen synthase kinase-3beta phosphorylation during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H297-308
All references(67)

Other accession IDs

MGD-MRK-1225, MGD-MRK-1229, MGD-MRK-29060, MGI:104906, MGI:1329017