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Akr1b3
Gene Detail
Symbol

Name
ID
Akr1b3
aldo-keto reductase family 1, member B3 (aldose reductase)
MGI:1353494
Synonyms
Ahr1, Ahr-1, Aldor1, Aldr1, ALR2, AR
Feature Type
protein coding gene
Genetic Map
Chromosome 6
14.87 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:34303934-34317497 bp, - strand
From VEGA annotation of GRCm38

  13564 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: AKR
Gene Tree: Akr1b3

Human
homologs
Human Homolog AKR1B1, aldo-keto reductase family 1, member B1 (aldose reductase)
NCBI Gene ID 231
neXtProt AC  NX_P15121
Human Synonyms  ADR, ALDR1, ALR2, AR
Human Chr (Location)  7q35; chr7:134442355-134459136 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased drinking, increased urination, and dilation of the renal tubules.
 
Phenotype Images(1)
Interactions
Akr1b3 interacts with 67 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (113)    Tissues (112)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 10
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(7) cDNA(17)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000014776 (Evidence)
Ensembl Gene ModelENSMUSG00000001642 (Evidence)
Entrez Gene11677 (Evidence)
DoTSDT.495566, DT.101377110, DT.91597078, DT.94339696, DT.94127579
NIA Mouse Gene IndexU066376, U046396, U027147, U021342
EC1.1.1.21
Consensus CDS ProjectCCDS19990.1
International Mouse Knockout Project StatusAkr1b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014776 VEGA Gene Model | MGI Sequence Detail 13564 C57BL/6J ±  kb
transcript OTTMUST00000035069 VEGA | MGI Sequence Detail 1406 Not Applicable 
polypeptide OTTMUSP00000015654 VEGA | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR018170 Aldo/keto reductase, conserved site
InterPro IPR020471 Aldo/keto reductase subgroup
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000003901 aldose reductase
References
(Earliest) J:7000 Duley JA, et al., Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3. Biochem Genet. 1982 Dec;20(11-12):1067-83
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(73)
Other
accession IDs
MGD-MRK-1225, MGD-MRK-1229, MGD-MRK-29060, MGI:104906, MGI:1329017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory