Akr1b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Akr1b1
aldo-keto reductase family 1 member B
MGI:1353494

18 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab B6.Cg-Akr1b1^tm1.1Kgab	abnormal vitamin C level	J:164548
Akr1b1^tm1Skc/Akr1b1^tm1Skc either: B6.129S7-Akr1b3^tm1Skc or (involves: 129S7/SvEvBrd * C57BL/6N)	abnormal kidney inner medulla morphology	J:77647
	abnormal renal water reabsorption	J:77647
	decreased urine calcium level	J:77647
	decreased urine chloride ion level	J:77647
	decreased urine creatinine level	J:77647
	decreased urine osmolality	J:77647
	decreased urine potassium level	J:77647
	decreased urine sodium level	J:77647
	decreased urine urea nitrogen level	J:77647
	dilated kidney collecting duct	J:77647
	normal homeostasis/metabolism phenotype	J:77647
	polydipsia	J:77647
	polyuria	J:77647
Akr1b1^tm1Tona/Akr1b1^tm1Tona involves: 129S/SvEv * C57BL/6	decreased urine osmolality	J:114187
	increased circulating calcium level	J:114187
	increased circulating magnesium level	J:114187
	increased urine calcium level	J:114187
	polyuria	J:114187
	weight loss	J:114187

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23