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Mapk12
Gene Detail
Symbol

Name
ID
Mapk12
mitogen-activated protein kinase 12
MGI:1353438
Synonyms
Erk6, P38gamma, Prkm12, Sapk3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:89130585-89140703 bp, - strand
From Ensembl annotation of GRCm38

  10119 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MAPK12
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk12

Human
homologs
MAPK12, mitogen-activated protein kinase 12
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6300
neXtProt AC: NX_P53778

Human Synonyms: ERK3, ERK6, ERK-6, MAPK 12, P38GAMMA, PRKM12, SAPK3, SAPK-3

Human Chr (Location): 22q13.33; chr22:50252902-50261759 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Mapk12 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile with no obvious abnormalities. Mice homozygous for a conditional allele activated in muscle cell exhibit decreased endurance exercise-induced mitochondrial biogenesis and angiogenesis.
 
Phenotype Images(2)
Interactions
Mapk12 interacts with 68 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell cycle, MAPK cascade, ...
Component cytoplasm, mitochondrion, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (47)    Tissues (18)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapk12 ; ZFIN mapk12a    NEW 
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022610 (Evidence)
Entrez Gene 29857 (Evidence)
UniGene 38343
DFCI TC1714711, TC1582292, TC1697886, TC1625869, TC1594073
DoTS DT.526192, DT.97347110, DT.101375129, DT.101375131, DT.101217483
NIA Mouse Gene Index U036521
EC 2.7.11.24
Consensus CDS Project CCDS27740.1
International Mouse Phenotyping Consortium Status Mapk12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022610 Ensembl Gene Model | MGI Sequence Detail 10119 C57BL/6J ±  kb
transcript ENSMUST00000088827 Ensembl | MGI Sequence Detail 1889 Not Applicable 
polypeptide ENSMUSP00000086207 Ensembl | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008352 Mitogen-activated protein (MAP) kinase, p38
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010153 mitogen-activated protein kinase 12
References
(Earliest) J:32241 Mertens S, et al., SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett. 1996 Apr 1;383(3):273-6
(Latest) J:217203 Del Reino P, et al., Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38gamma and p38delta, linking inflammation and cancer in colitis-associated colon cancer. Cancer Res. 2014 Nov 1;74(21):6150-60
All references(43)
Other
accession IDs
MGI:2146196

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory