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Esr1
Gene Detail
 Symbol
Name
ID
Esr1
estrogen receptor 1 (alpha)
MGI:1352467
Synonyms ERa, ER[a], ERalpha, ER-alpha, ESR, Estr, Estra, Nr3a1
Feature Type protein coding gene
Genetic Map
Chromosome 10
2.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:4611593-5005614 bp, + strand
From VEGA annotation of GRCm38

  394022 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esr1

Human
homologs
Human Homolog ESR1, estrogen receptor 1
NCBI Gene ID 2099
neXtProt AC  NX_P03372
Human Synonyms  ER, Era, ESR, ESRA, ESTRR, NR3A1
Human Chr (Location)  6q25.1; chr6:151690496-152103274 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human ESR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(1) Targeted(28)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have reduced skeletal growth and are infertile. Females exhibit hypoplastic uteri and nonovulatory ovaries, while males produce few sperm of low motility and fertilizing capacity.
 
Phenotype Images(3)
Interactions
Esr1 interacts with 392 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (96 annotations)
Process androgen metabolic process, antral ovarian follicle growth, ...
Component cytoplasm, Golgi apparatus, ...
Function beta-catenin binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (451)    Tissues (312)    Images (58)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 269
RT-PCR 182
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(5) cDNA(28) Primer pair(7) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000020886 (Evidence)
Ensembl Gene ModelENSMUSG00000019768 (Evidence)
Entrez Gene13982 (Evidence)
DFCITC1584052, TC1606765, TC1646616, TC1651684, TC1672805
DoTSDT.101348783, DT.101348784, DT.110614470, DT.110614480, DT.489700, DT.527869, DT.91352685, DT.91362571, DT.94245603, DT.94254079
Consensus CDS ProjectCCDS56678.1
International Mouse Knockout Project StatusEsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020886 VEGA Gene Model | MGI Sequence Detail 394022 C57BL/6J ±  kb
transcript OTTMUST00000049380 VEGA | MGI Sequence Detail 6339 Not Applicable 
polypeptide OTTMUSP00000022868 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(12) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(1978 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001292 Oestrogen receptor
InterPro IPR024178 Oestrogen receptor/oestrogen-related receptor
InterPro IPR024736 Oestrogen-type nuclear receptor final C-terminal domain
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000007204 estrogen receptor
References (Earliest) J:113710 Greene GL, et al., Sequence and expression of human estrogen receptor complementary DNA. Science. 1986 Mar 7;231(4742):1150-4
(Latest) J:210994 Laws MJ, et al., Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice. PLoS Genet. 2014 Mar;10(3):e1004230
All references(538)
Other
accession IDs
MGD-MRK-38393, MGD-MRK-9655, MGI:109348, MGI:2143478, MGI:3034239

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory